2.4.2.29	guanine34 in tRNA + 7-aminomethyl-7-carbaguanine	-	
2.4.2.29	guanine34 in tRNA + 7-aminomethyl-7-carbaguanine	the enzyme is involved in the hypermodification of cognate tRNAs, leading to the exchange of G34 by 7-methylamino-7-deazaguanine at the wobble position in the anticodon loop	
2.4.2.29	guanine34 in tRNA + 7-aminomethyl-7-carbaguanine	the enzyme catalyzes the posttranscriptional base exchange of the queuosine precursor 7-(aminomethyl)-7-deazaguanine with the genetically encoded guanine in tRNAASp, tRNAAsn, tRNAHis and tRNATyr	
2.4.2.29	guanine34 in tRNA + 7-aminomethyl-7-carbaguanine	the enzyme exchanges the genetically encoded guanine at position 34 with a queuine precursor 7-(aminomethyl)-7-deazaguanine	
2.4.2.29	guanine34 in tRNA + 7-aminomethyl-7-carbaguanine	the enzyme is responsible for the posttranscriptional modification of specific tRNAs (Asn, Asp, His and Tyr) with queuine. The enzyme catalyzes base exchange of guanosine34 with 7-aminomethyl-7-deazaguanine	
2.4.2.29	guanine34 in tRNA + queuine	-	
2.4.2.29	additional information	post-translational modification of tRNA	
2.4.2.29	additional information	higher expression of the subunit TGT60KD in cancer cells than in normal cells. The expression levels of the TGT60KD subunit regulate enzyme activity and the level of queuosine. TGT60KD plays significant roles in carcinogenesis	
2.4.2.29	additional information	formation of queuosine	
2.4.2.29	additional information	the 60000 Da subunit of the enzyme plays a role in colon carcinogenesis