1.14.99.38	cholesterol + AH2 + O2	-	
1.14.99.38	additional information	25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol	
1.14.99.38	cholesterol + AH2 + O2	cholesterol 25-hydroxylase has the capacity to play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein processing and ultimately leads to inhibition of gene transcription	
1.14.99.38	cholesterol + AH2 + O2	genetic variability in the set of cholesterol metabolism genes: cholesterol 25-hydroxylase, cholesterol 24-hydroxylase and ATP-binding cassette transporter A1 does not influence the development of Alzheimer‘s disease	
1.14.99.38	cholesterol + AH2 + O2	lower 25-hydroxylation enzyme activity by CYP1A2 compared to marker enzyme CYP3A4	
1.14.99.38	cholesterol + AH2 + O2	lower 25-hydroxylation enzyme activity by CYP2C9 compared to marker enzyme CYP3A4	
1.14.99.38	cholesterol + AH2 + O2	lower 25-hydroxylation enzyme activity by CYP2D6 compared to marker enzyme CYP3A4	
1.14.99.38	cholesterol + AH2 + O2	production of 25-hydroxycholesterol by intact CYP3A4, most significant activity is 25-hydroxylation, which is higher than that of 4beta-hydroxylation, a marker activity of CYP3A4	
1.14.99.38	cholesterol + AH2 + O2	testicular macrophagers play an important role in the differentiation of Leydig cells through the secretion of 25-hydroxycholesterol	
1.14.99.38	cholesterol + AH2 + O2	the enzyme has the capacity to synthesize an active and potent regulator of the sterol response element binding protein pathway within the cell