1.14.13.200 tetracenomycin A2 + 2 O2 + 2 NAD(P)H + 2 H+ biosynthesis tetracenomycin C, a polyketide antitumor antibiotic 1.14.13.200 tetracenomycin B2 + 2 O2 + 2 NAD(P)H + 2 H+ natural reaction in Streptomyces olivaceus