4.6.1.18	additional information	enzyme expressed in K-562 cell is cytotoxic and cytostatic, IC50 value 0.0009 mM	
4.6.1.18	additional information	enzyme is both angiogenic and bactericidal. Domains II, amino acids 71-76, and III, amino acids 89-104, of RNase A-2 are both important for bactericidal activity	
4.6.1.18	additional information	isoform RNase1 is bactericidal with potent activities against the gramnegative bacteria Escherichia coli and Pseudomonas aeruginosa but only mild effects against the gram-positive bacteria Staphylococcus aureus	
4.6.1.18	additional information	isoform RNase2 is bactericidal with potent activities against the gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa but only mild effects against the gram-positive bacteria Staphylococcus aureus	
4.6.1.18	additional information	isoform RNase3 is bactericidal with potent activities against the gramnegative bacteria Escherichia coli and Pseudomonas aeruginosa but only mild effects against the gram-positive bacteria Staphylococcus aureus	
4.6.1.18	additional information	the enzyme degrades single-stranded and/or double-stranded RNA	
4.6.1.18	RNA + H2O	-	
4.6.1.18	RNA + H2O	endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA