3.4.23.16	eIF4GI + H2O	perhaps cleavage of eIF4G is an event that contributes to a more efficient translation of the genomic HIV-1 mRNA, proteolysis of eIF4GI inhibits protein synthesis directed by capped mRNAs but allows internal ribosome entry site-driven translation, purified enzyme cleaves at positions 678-679, 681-682 and 1086-1087, separating the three domains of the initiation factor	
3.4.23.16	Gag polyprotein + H2O	-	
3.4.23.16	Gag polyprotein + H2O	substrate sites, overview	
3.4.23.16	Gag polyprotein + H2O	Gag polyprotein with cleavage-site P12-P5/P5'-P12' residues	
3.4.23.16	Gag precursor polyprotein + H2O	-	
3.4.23.16	Gag protein + H2O	proteolytic cleavage in the host cell cytoplasm	
3.4.23.16	Gag-Pol polyprotein + H2O	-	
3.4.23.16	Gag-Pol polyprotein + H2O	proteolytic cleavage in the host cell cytoplasm	
3.4.23.16	Gag-Pol precursor polyprotein + H2O	-	
3.4.23.16	Gag-pro-pol polyprotein + H2O	-	
3.4.23.16	GagPol polyprotein + H2O	-	
3.4.23.16	matrix-capsid polyprotein + H2O	i.e. DTGNNSQVSQNYPIVQNLQGQMVH	
3.4.23.16	additional information	the enzyme plays an essential role in the late-stage maturation step of the virus replication cycle. HIV-1 proteinase autocatalyzes its own cleavage from the Pr165 polyprotein precursor and then cleaves both polyproteins at other specific sites to produce mature proteins	
3.4.23.16	additional information	regulation of the protease in the viral life cycle: transframe region flanking the N-terminus of the protease may function as a negative regulator for protein folding and dimerization. The low dimer stability of the protease precursor relative to that of the mature enzyme is an ideal way of preventing the emergence of enzymatic functions until assembly of the viral particle is complete	
3.4.23.16	additional information	the enzyme is responsible for the processing of gag and gag-pol polyprotein precursors to produce structural proteins and enzymes for the mature virus	
3.4.23.16	additional information	the enzyme facilitates viral maturation by cleaving ten asymmetric and nonhomologous sequences in the Gag and Pol polyproteins	
3.4.23.16	additional information	the enzyme is essential for the replication of the virus	
3.4.23.16	additional information	the enzyme is involved in regulation of the incorporation of reverse transcriptase in the viral early assembly complex comprising reverse transcriptase, genomic RNA, Gag, Gag-Pol, tRNALys, and lysyl tRNA synthetase, HIV-1 protease activity is negatively regulated by the lysyl tRNA synthetase	
3.4.23.16	additional information	Arg-Val-Leu-Ala-Glu-Ala-Met mimics the real substrate	
3.4.23.16	nucleocapsid protein + H2O	-	
3.4.23.16	Pol polyprotein + H2O	substrate sites, overview	
3.4.23.16	Poly(A)-binding protein + H2O	-	
3.4.23.16	translation initiation factor eIF4GI + H2O	-