3.4.22.64	cationic channel subunit transient receptor potential channel 1 + H2O	i.e. TRPC1, plays a role in regulating innate immunity by modulating channel complexes during inflammatory responses	
3.4.22.64	gasdermin D + H2O	-	
3.4.22.64	additional information	-	
3.4.22.64	additional information	overexpression induces apoptosis	
3.4.22.64	additional information	phenotype of animals deficient in caspase-11: resistant to lipopolysaccharide-induced caspase-1 processing, interleukin-1alpha and interleukin-beta secretion, and endotoxic shock	
3.4.22.64	additional information	the enzyme is a critical initiator caspase responsible for the activation of caspase-3. The enzyme is an upstream activator of caspase-1. Caspase-11 deficient animals have a reduced number of apoptotic cells and a defect in caspase-3 activation after middle cerebral artery occlusion. The enzyme is A VERY IMPORTANT REGULATOR OF APOPTOSIS	
3.4.22.64	additional information	enzyme is involved in cytokine activation	
3.4.22.64	additional information	pro-caspase-11 physically interacts with pro-ICE in cells, the expression of casp-11 is essential for activation of ICE. Caspase-11 is a compinent of ICE complex and is required for the activation of ICE. Important role of ICE and caspase-11 in mediating apoptosis in pathological conditions	
3.4.22.64	additional information	the enzyme may play a very important role in apoptosis and inflammatory responses and may be an upstream regulator of ICE	
3.4.22.64	additional information	the enzyme is involved in cytokine activation	
3.4.22.64	additional information	C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation	
3.4.22.64	additional information	caspase-11 has a regulatory role in ethanol-induced apoptosis. Suppression of caspase-11 expression may be a mechanism by which Scutellariae radix (Chinese herbal medicine) exerts its cytoprotective effect	
3.4.22.64	additional information	caspase-11 plays a crucial role in both inflammation and apoptosis. Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin (IL)-1 and IL-18, but also activates caspase-3, leading to cellular apoptosis under pathological conditions. The expression of caspase-11 is strongly induced at both mRNA and protein levels by inflammatory stimuli such as lipopolysaccharide, interferon-Q Q, and tumor necrosis factor-K K in C6 rat glial cells as well as primary astrocytes. Induction of caspase-11 by LPS in astrocytes is mediated through the p38 MAPK pathway. Inflammatory induction of caspase-11 in astrocytes may play an important role in both inflammatory responses involving these cells and auto-regulatory apoptosis of activated astrocytes in inflammatory sites	
3.4.22.64	additional information	neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice	
3.4.22.64	additional information	neurotoxicity of 1-methyl-4-pheny-1,2,3,6-tetrahydropyridine may be mediated via activation of the caspase-11 cascade and inflammatory cascade, as well as the mitochondrial apoptotic cascade	
3.4.22.64	additional information	a pathway modulating inflammatory-cell migration involve caspase-11 and actin interacting protein 1	
3.4.22.64	additional information	caspase-11 may be a central regulator of multiple events, including cell migration, cytokine maturation and apoptosis, during inflammation responses. Caspase-11 interacts physically and functionally with actin interacting protein 1, an activator of cofilin-mediated actin depolymerization. Caspase-11 and actin interacting protein 1 work cooperatively to promote cofilin-mediated actin depolymerization	
3.4.22.64	additional information	Flightless-I regulates the subcellular distribution of caspase-11 by promoting its localization at the cell leading edge	
3.4.22.64	additional information	other caspases are substrates of caspase-11	
3.4.22.64	procaspase-1 + H2O	-	
3.4.22.64	procaspase-3 + H2O	the enzyme is a critical initiator caspase responsible for the activation of caspase-3