3.4.17.23	additional information	ACE2 plays a crucial role in liver fibrogenesis	
3.4.17.23	additional information	ACE2 plays a key role in pulmonary, cardiovascular and hypertensive and diabetic kidney diseases. ACE2 plays a pivotal role in maintaining a balanced status of the RAS synergistically with ACE by exerting counter-regulatory effects	
3.4.17.23	additional information	ACE2 plays a pivotal role in the central regulation of blood pressure and volume homeostasis	
3.4.17.23	additional information	ACE2 plays a protective role in organs directly related to hypertension and associated diseases	
3.4.17.23	additional information	the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited	
3.4.17.23	additional information	ACE2 activation promotes antithrombotic activity. ACE2 is an ACE, EC 3.4.15.1, homologue	
3.4.17.23	additional information	ACE2 is a terminal carboxypeptidase and the receptor for the SARS and NL63 coronaviruses. Soluble sACE2 acts as receptor binding SARS-CoV glycoprotein S pseudotyped FIV virus and blocks virus infection of target cells	
3.4.17.23	additional information	a combination of ACE2 and ACE convert amyloid-beta protein 43 to amyloid-beta protein 40	
3.4.17.23	QRPRLSHKGPMPF + H2O	i.e. apein(1-13)	
3.4.17.23	YGGFLRRIRPKLK + H2O	i.e. dynorphin A 1-13