2.7.4.3	2 ADP	the enzyme plays a key role in maintaining the balance of ADP and ATP in cell	
2.7.4.3	ADP + ADP	facilitates transfer of high-energy phosphorylss and signal communication between mitochondria and actomyosin in cardiac muscle	
2.7.4.3	ADP + ADP	provides unique buffering role against rapid concentration changes of any component of the adenylate pool	
2.7.4.3	ADP + ADP	facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems	
2.7.4.3	ADP + ADP	involved in energy metabolism	
2.7.4.3	ADP + TDP	Escherichia coli adenylate kinase is able to synthesize TTP, but the activity is too low to explain the high rate of TTP accumulation uring amino acid starvation of cells	
2.7.4.3	ATP + AMP	-	
2.7.4.3	ATP + AMP	the enzyme is involved in regulating concentration of ATP in cells	
2.7.4.3	ATP + AMP	the enzyme plays a key role in maintaining the balance of ADP and ATP in cell	
2.7.4.3	additional information	adenylate kinase activity Is required for Mre11/Rad50-mediated DNA tethering	
2.7.4.3	additional information	adenylate kinase is involved in the control of the rate of glycolysis	
2.7.4.3	additional information	adenylate kinase participates in the regulation of ADP-dependent endocytosis of high-density lipoprotein by consuming the ADP generated by the ecto-F1-ATPase	
2.7.4.3	additional information	adenylate kinase activity of the Mre11/Rad50 complex, which is part of a DNA repair complex, promotes DNA-DNA associations	
2.7.4.3	additional information	adenylte kinase-catalysed ADP production in the vicinity of K/ATP channels is involved in channel regulation	
2.7.4.3	additional information	interaction between mitochondrial adenylate kinase and nucleoside diphosphate kinase. Adenylate kinase stimulates nucleoside diphosphate kinase activity, whereas nucleoside diphosphate kinase inhibits adenylate kinase activity. the net effect may be unchanged ADP production albeit with different rates of substrate consumption	
2.7.4.3	additional information	Rad50 adenylate kinase activity is required for DNA tethering	
2.7.4.3	additional information	secretion of adenylate kinase 1 is required for extracellular ATP synthesis in myotubes	
2.7.4.3	additional information	the cystic fibrosis transmembrane conductance regulator (CFTR) has adenylate kinase activity as an ABC adenylate kinase. ATP enables CFTR photolabeling by 8-N3-AMP, and AMP increases 8-N3-ATP photolabeling at ATP-binding site 2. AMP interacts with CFTR in an ATP-dependent manner and alters ATP interaction with the adenylate kinase active center ATP-binding site. Two other ABC proteins, Rad50 and a structural maintenance of chromosome protein, also have adenylate kinase activity. All three ABC adenylate kinases bind and hydrolyze ATP in the absence of other nucleotides