2.7.10.2 ATP + a protein - 2.7.10.2 ATP + a protein enzyme plays an important role in spermatogenesis 2.7.10.2 ATP + a protein ILK is a receptor-proximal protein kinase regulating integrin-mediated signal transduction 2.7.10.2 ATP + a protein enzyme is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation 2.7.10.2 ATP + a protein ILK is involved in agonist stimulated, Pi(3)K-dependent, PKB/AKT activation. ILK is thus a receptor-proximal effector for the Pi(3)K-dependent, extracellular matrix and growth factor mediated, activation of PKB/AKT, and inhibition of GSK-3 2.7.10.2 ATP + a protein the enzyme controls shoot and floral meristem size 2.7.10.2 ATP + a protein enzyme contributes to signal transduction 2.7.10.2 ATP + a protein TESK1 has a specific function in spermatogenesis 2.7.10.2 ATP + a protein it is likely that LIMK is involved in developmental or oncogenic processes through interactions with these LIM-containing proteins 2.7.10.2 ATP + a protein the enzyme induces formation of actin stress fibers and focal adhesions 2.7.10.2 ATP + a protein role for this kinase in spermatogenesis 2.7.10.2 ATP + a protein proximal mediators of IL-1 signaling 2.7.10.2 ATP + a protein apoptosis-inducing kinase 2.7.10.2 ATP + a protein NF-kappaB-activating and cell death-inducing kinase 2.7.10.2 ATP + a protein the enzyme is a downstream effector of activated Ras. Interaction with Ras leads to Raf-1 activation and results in transduction of cell growth and differentiation signals 2.7.10.2 ATP + a protein enzyme functions as an intermediary in TNFalpha-induced apoptosis 2.7.10.2 ATP + a protein enzyme is required in early larval development 2.7.10.2 ATP + a protein enzyme plays a critical role in cell growth and development 2.7.10.2 ATP + a [homeodomain-interacting protein kinase 2]-L-tyrosine - 2.7.10.2 ATP + a [protein]-L-tyrosine - 2.7.10.2 ATP + a [protein]-L-tyrosine activation of Syk is responsible for K-Cl cotransport in SS cells by relieving Src-mediated inhibition of the transporter 2.7.10.2 ATP + Abl Abl is an important substrate for Src signalling in normal cells 2.7.10.2 ATP + Abl Abl is an important substrate for Src signalling in normal cells, Abl is also required for Src-induced transformation of mouse fibroblasts, overview 2.7.10.2 ATP + Akt tyrosine kinase tyrosine kinase Akt is phosphorylated by PYK2 for activation of the Akt signaling pathway, overview 2.7.10.2 ATP + Bad protein substrate of Akt 2.7.10.2 ATP + beta-catenin - 2.7.10.2 ATP + Cas protein - 2.7.10.2 ATP + cdc2 the Cdc2-inhibitory kinase is required for preventing premature activation of the mitotic program. Maternally provided Dwee1 is sufficient for regulating Cdc2 during embryogenesis 2.7.10.2 ATP + cortactin - 2.7.10.2 ATP + cyclin-associated cyclin-dependent kinase Wee1 negatively regulates cyclin-dependent kinases by phosphorylation on Y15 2.7.10.2 ATP + epidermal growth factor receptor the activated Abl tyrosine kinase negaively regulates endocytosis of the epidermal growth factor, e.g. in NR6 cells, overview, Abl allows the ligand-activated EGFR to escape Cbl-dependent down-regulation by inhibiting the accumulation of Cbl at the plasma membrane in response to epidermal growth factor stimulation and disrupting the formation of the EGFR-Cbl complex without affecting Cbl protein stability 2.7.10.2 ATP + ezrin - 2.7.10.2 ATP + FAK - 2.7.10.2 ATP + glycogen synthase kinase 3beta substrate of Akt 2.7.10.2 ATP + IkappaBalpha-L-tyrosine p56lck regulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through tyrosine phosphorylation of IkappaBalpha following hypoxia/reoxygenation, molecular mechanism, physiological role 2.7.10.2 ATP + NaV1.2 channel Y66 and Y1893, which are in consensus sequences appropriate for binding to the Fyn SH2 domain after phosphorylation, are both required for optimal binding and regulation by Fyn. Y730, which is located near the SH3-binding motif in LI-II, and Y1497 and Y1498 in the inactivation gate in LIII-IV, are also required for optimal regulation, but phosphorylation of these sites likely promotes fast inactivation 2.7.10.2 ATP + p120 protein - 2.7.10.2 ATP + p190 GTPase - 2.7.10.2 ATP + p32-L-tyrosine - 2.7.10.2 ATP + p34cdc2 Wee1 kinase inhibits mitosis by directly phosphorylating p34cdc2 on Y15 2.7.10.2 ATP + PAK1 Jak2 is involved in the regulation of serine-threonine kinase PAK1, maximal cell motility is required for tyrosyl phosphorylation of PAK1 2.7.10.2 ATP + paxillin - 2.7.10.2 ATP + PIKE-A i.e. phosphatidylinositol 3-kinase enhancer-activating Akt, phosphorylation by fyn is essential for PIKE-A complex formation and apoptotic cleavage, overview 2.7.10.2 ATP + plakoglobin - 2.7.10.2 ATP + protein CSK phosphorylates other members of the src-family of tyrosine kinases at their regulatory carboxy-terminus 2.7.10.2 ATP + protein phosphorylates the regulatory C-terminal tyrosine residue present on cytoplasmic tyrosine kinases of the Src family 2.7.10.2 ATP + protein CSK phosphorylates other members of the src-family of tyrosine kinases at their regulatory carboxy-terminus. By regulating the activity of these kinases, CSK may play an important role in cell growth and development 2.7.10.2 ATP + protein tyrosine specifically phosphorylates Tyr527 of p60c-src from neonatal rat brain, specifically phosphorylates a negative regulatory site of p60c-src 2.7.10.2 ATP + protein tyrosine p135tyk2 tyrosine kinase directly binds and tyrosine phosphorylates alpha subunit of the type I IFN receptor, IFN-R 2.7.10.2 ATP + protein tyrosine kinase Yes Csk inactivates the enzyme substrate 2.7.10.2 ATP + Rho protein - 2.7.10.2 ATP + Shc protein - 2.7.10.2 ATP + Src family kinase substrate of the protein kinases CSK and CHK, which specifically phosphorylate a tyrosine residue at the C-terminus forming intramolecular bonds to the SH2 domain and inhibiting the Src family kinase, overview 2.7.10.2 ATP + Src family kinase terminal Src kinase Csk specifically phosphorylates Src family kinases on a C-terminal Tyr residue, which down-regulates their activities, identification of the docking determinants in Src recognized by the Csk substrate-docking site 2.7.10.2 ATP + Src protein MATK can phosphorylate the carboxyl-terminal conserved tyrosine of the Src protein 2.7.10.2 ATP + STAT3 - 2.7.10.2 ATP + Tc10/Cdc42 GTPase-activating protein physical and functional interaction of Fyn with the brain-enriched Rho GTPase-activating protein Tc10/Cdc42 GTPase-activating protein, i.e. TCGAP, TCGAP is involved in Fyn-mediated regulation of axon and dendrite outgrowth 2.7.10.2 ATP + [androgen receptor]-L-tyrosine - 2.7.10.2 ATP + [aryl hydrocarbon receptor]-L-tyrosine Src tyrosine kinases are involved in a signaling transduction pathway activating aryl hydrocarbon receptor AhR-mediated signalling by omeprazole or 2,3,7,8-tetrachlorodibenzo-4-dioxin TCDD ligand-binding, AhR phosphorylation at Tyr320, the omeprazole-dependent mechanism probably involves S318 and K316 2.7.10.2 ATP + [c-Cbl]-L-tyrosine proto-oncogenic PTK protein substrate 2.7.10.2 ATP + [disabled-1 adaptor protein]-L-tyrosine activation of disabled-1 adaptor protein Dab1, which is responsible for regulation of neuronal migrations during mammalian brain development, Reelin induces tyrosine-phosphorylated-Dab1 degradation and downregulates Dab1 expression in primary cortical neurons, mutant non-phosphorylated Dab1 are not degraded, pathway regulation, overview 2.7.10.2 ATP + [estrogen receptor alpha]-L-tyrosine - 2.7.10.2 ATP + [FAK]-L-tyrosine activation of FAK during epiboly and gastrulation by dynamic phosphorylation at Tyr861 2.7.10.2 ATP + [fibroblast growth factor receptor FGFR2]-L-tyrosine activation by non-receptor tyrosine kinase Pyk2, interaction via the FGFR juxtamembrane and the Pyk2 kinase domain, activation is antagonized by tyrosine phosphatase Shp2 2.7.10.2 ATP + [fibroblast growth factor receptor FGFR3]-L-tyrosine activation by non-receptor tyrosine kinase Pyk2, interaction via the FGFR juxtamembrane and the Pyk2 kinase domain, activation is antagonized by tyrosine phosphatase Shp2 2.7.10.2 ATP + [kinase Btk29]-L-tyrosine - 2.7.10.2 ATP + [P-110]-L-tyrosine - 2.7.10.2 ATP + [p110 catalytic subunit of PI 3-kinase]-L-tyrosine - 2.7.10.2 ATP + [p21Cip1]-L-tyrosine - 2.7.10.2 ATP + [p27Kip1]-L-tyrosine - 2.7.10.2 ATP + [p57Kip2]-L-tyrosine - 2.7.10.2 ATP + [parkin]-Tyr143 - 2.7.10.2 ATP + [protein kinase C zeta]-L-tyrosine - 2.7.10.2 ATP + [protein]-L-tyrosine - 2.7.10.2 ATP + [ring canal protein]-L-tyrosine - 2.7.10.2 ATP + [Runx1]-L-tyrosine the enzyme phosphorylates transcription factor Runx1 and regulates Runx1-mediated megakaryocyte maturation 2.7.10.2 ATP + [Sam68]-L-tyrosine SRMS regulates the phosphorylation of Sam68 in an EGF-dependent manner in MDA-MB 231 cells 2.7.10.2 ATP + [Sam68]-L-tyrosine the enzyme (SRMS) regulates the phosphorylation of Sam68 in an EGF-dependent manner in MDA-MB 231 cells 2.7.10.2 ATP + [Src-family protein tyrosine kinase]-L-tyrosine i.e. SFK, substrate of protein tyrosine kinases Csk and Chk, phosphorylation at the regulatory tyrosine leading to inhibition of the SFK 2.7.10.2 ATP + [Stat5B]-L-tyrosine activation by non-receptor tyrosine kinase Pyk2 2.7.10.2 ATP + [transmembrane adaptor protein LAT]-L-tyrosine substrate of ZAP-70 2.7.10.2 ATP + [ZAP-70]-L-tyrosine substrate of Lck, Fyn, and c-Abl, leads to ZAP-70 activation, mechanism 2.7.10.2 gelsolin + ATP phosphorylation by PYK2 increases the binding of gelsolin to phosphoatidylinositol lipids and actin polymerization at the fibroblastic cell periphery 2.7.10.2 additional information - 2.7.10.2 additional information PTK6 may function as an intracellular signal transducer in specific tissues 2.7.10.2 additional information role for JAK3 in hematopoiesis and T- and B-cell development 2.7.10.2 additional information transcriptionally induced in normal T cells by interleukin 2 stimulation, roles in T cell proliferation and differentiation 2.7.10.2 additional information involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells 2.7.10.2 additional information JAK3 kinase is associated with terminal differentiation of hematopoietic cells 2.7.10.2 additional information sensitizes mammary epithelial cells to epidermal growth factor 2.7.10.2 additional information required maternally for the establishment of the normal array of embryonic segments 2.7.10.2 additional information plays important roles in cell adhesion, functions downstream of integrins, enzyme is involved in integrin-mediated cell adhesion signaling 2.7.10.2 additional information is likely to participate in a variety of integrin-extracellular-matrix-dependent signaling events during morphogenesis 2.7.10.2 additional information the enzyme transduces signals initiated by integrin engagement and G protein-coupled receptors. Several splice isoforms of FAK are preferentially expressed in rat brain, some of which have an increased autophosphorylation activity 2.7.10.2 additional information activation of FadK may be an important early step in intracellular signal transduction pathways triggered in response to cell interactions with the extracellular matrix 2.7.10.2 additional information participate in signalling pathways activated in response to cell interaction, role for FAK in gastrulation 2.7.10.2 additional information oncogene v-fps induces fibrosarcomas in birds 2.7.10.2 additional information associated with breast cancer and osteoporosis 2.7.10.2 additional information mutations in the gene encoding the Drosophila tyrosine kinase Abelson substantially enhanced the severity of the CNS phenotype of armadillo mutations, consistent with these proteins functioning co-operatively at adherens junctions in both the CNS and the epidermis 2.7.10.2 additional information enzyme plays a critical role in a variety of signal transduction pathways 2.7.10.2 additional information lskT-encoded protein-tyrosine kinase may aid in transducing proliferative or differentiative signals unique to lymphocytes 2.7.10.2 additional information enzyme is implicated in neoplastic transformation 2.7.10.2 additional information enzyme is involved in pathway for signaling through glycosyl-phosphatidylinositol (GPI)-anchored membrane proteins 2.7.10.2 additional information involved in signal transduction by association with a number of membrane receptors 2.7.10.2 additional information elevated levels of p56tck can contribute to the malignant properties of LSTRA cells 2.7.10.2 additional information p56lck can positively regulate T-cell functions and it mediates at least some of the effects of CD4 and CD8 on T-cell activation 2.7.10.2 additional information p56lck participates in lymphocyte-specific signal transduction pathways. Disturbances in lck expression may contribute to the pathogenesis of some human neoplastic diseases 2.7.10.2 additional information yes gene product is likely to play an important role in oogenesis or early development 2.7.10.2 additional information enzyme may serve specialized functions in hemopoietic cells, it is possible that damage to HCK may contribute to the pathogenesis of some human leukemias 2.7.10.2 additional information Hck is involved in a number of cell signal transduction pathways, frequently in pathways associated with immune response 2.7.10.2 additional information participates in signal transduction events regulating the growth, differentiation and function of phagocytes 2.7.10.2 additional information it may be involved in key regulatory processes 2.7.10.2 additional information may be specifically involved in the cell growth of hepatocytes or in the step of hepatocarcinogenesis 2.7.10.2 additional information may interact with the intracellular domain of cell surface receptors 2.7.10.2 additional information participates in the signalling pathways of a broad range of cytokines 2.7.10.2 additional information enzyme is crucial for B cell development. Loss of kinase activity results in the human immunodeficiency, X-linked agammaglobulinemia, characterized by a failure to produce B cells 2.7.10.2 additional information possible function during secondary steps of tumor progression 2.7.10.2 additional information directly implicated in the pathogenesis of X-linked agammaglobulinaemia 2.7.10.2 additional information specifically phosphorylates Tyr527 of p60c-src from neonatal rat brain. Specifically phosphorylates a negative regulatory site of p60c-src 2.7.10.2 additional information deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia 2.7.10.2 additional information p135tyk2 tyrosine kinase directly binds and tyrosine phosphorylates alpha subunit of the type I IFN receptor, IFN-R. Tyk2 protein functions as part of a receptor complex to initiate intracellular signaling in response to type I interferons 2.7.10.2 additional information CSK is involved in regulation of src family kinases 2.7.10.2 additional information ZAP-70 that associates with T cell antigen receptor zeta chain and undergoes tyrosine phosphorylation following TCR stimulation 2.7.10.2 additional information tandem ZAP-70 SH2 domains bind phosphorylated, but not nonphosphorylated, T cell antigen receptor zeta cyt. The NH2-terminal ZAP-70 SH2 domain also binds to T cell antigen receptor zeta cyt but with 100-fold lower affinity. No binding is observed with the COOH-terminal ZAP-70 SH2 domain. Similar studies demonstrate that the ZAP-70 tandem SH2 domain can bind a T cell antigen receptor zeta 3 TAM peptide in which both tyrosine residues are phosphorylated: Little or no binding is observed with peptides phosphorylated at only one tyrosine residue, or a nonphosphorylated peptide. Binding of the tandem SH2 domains to the other two TCR zeta TAM peptides and to a CD3 epsilon TAM peptide is also observed. All four doubly tyrosine phosphorylated TAM peptides cross-compete with each other for binding to the tandem SH2 domains of ZAP-70. The affinity of these peptides for the tandem SH2 construct demonstrates a hierarchy of TAM zeta 1, TAM zeta 2, TAM epsilon, TAM zeta 3 2.7.10.2 additional information perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Syk-deficient radiation chimaeras fail to accumulate mature B cells, Syk-deficient mice show impaired development of thymocytes using the V gamma 3 variable region gene, Syk is not required for signalling through the IL-2 and G-CSF receptors 2.7.10.2 additional information mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency 2.7.10.2 additional information Rlk has potential functions in intrathymic T cell development and mature T cell signaling 2.7.10.2 additional information JAK3 deficiency in a patient with severe combined immunodeficiency over 20 years after bone marrow transplantation: persistence of genetically and biochemically defective autologous B cells, associated with reconstitution of cellular and humoral immunity, suggests that integrity of the gammac-JAK3 signalling pathway is not strictly required for immunoglobulin production 2.7.10.2 additional information JAK3 deficiency in humans results in autosomal recessive T-B+ severe combined immunodeficiency disease 2.7.10.2 additional information HYL plays a significant role in the signal transduction of hematopoietic cells 2.7.10.2 additional information enzyme plays a pivotal role in cell signal transduction 2.7.10.2 additional information Ntk may play an inhibitory role in the control of T-cell proliferation 2.7.10.2 additional information may play an important role in thymopoiesis, role in controlling cellular growth and differentiation 2.7.10.2 additional information role for JAK1 kinase in the differentiation or function of a subset of CNS neurons 2.7.10.2 additional information effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells 2.7.10.2 additional information autosomal recessive form of severe combined immunodeficiency disease in which ZAP-70 is absent as a result of mutations in the ZAP-70 gene. This absence is associated with defects in TCR signal transduction. Integral role in T cell activation and differentiation 2.7.10.2 additional information may play a role in the growth and differentiation of hematopoietic cells 2.7.10.2 additional information may have a role in human cancer 2.7.10.2 additional information Batk may function as a brain-specific regulator of kinases involved in the development and maintenance of the nervous system 2.7.10.2 additional information JAK3 splice isoforms are functional in JAK3 signaling and may enrich the complexity of the intracellular response functional in IL-2 or cytokine signaling 2.7.10.2 additional information activating motif occurs in four discrete steps: binding of p59fyn, phosphorylation of the motif, binding of ZAP-70, and activation of ZAP-70 kinase activity 2.7.10.2 additional information Ctk is involved in the regulation of neural function and differentiation of male germ cells through interactions with members of the Src family kinases 2.7.10.2 additional information mutations of the Janus family kinase JAK3 are responsible for autosomal recessive severe combined immunodeficiency. Abnormalities in tyrosine phosphorylation of JAK3 in response to interleukin-2 (IL-2) and IL-4 is present in all patients. In one patient carrying a single amino acid change, Glu481Gly, in the JH3 domain of JAK3, a partially conserved IL-2 responses is observed resulting in reduced but detectable levels of JAK3 and STAT5 phosphorylation. A single cysteine to arginine substitution, Cys759Arg, results in high basal levels of constitutive JAK3 tyrosine phosphorylation unresponsive to either downregulation by serum starvation or cytokine-mediated upregulation 2.7.10.2 additional information could be responsible for the tyrosine phosphorylation observed in a murine thymic medullary epithelial cell line E-5 following complex formation with thymocytes 2.7.10.2 additional information appear to play a role in B-cell-IgM and FcERI receptor signaling 2.7.10.2 additional information functions during reinitiation of meiotic division 2.7.10.2 additional information TGF-beta RII expression is down-regulated in cells treated with exogenous TGF-beta1 2.7.10.2 additional information type II receptor isoforma exist which play preferential binding to TGF-beta2 and have their own defined role in debvelopment 2.7.10.2 additional information the kinase induces progression through the cell cycle for both meiotic and mitotic cells 2.7.10.2 additional information the receptor shares two-hit inactivation mechanism with tumor suppressor genes and mutation of it may occur in the early stage of tumorgenesis 2.7.10.2 additional information mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2 2.7.10.2 additional information activin and its receptor play an important role in development 2.7.10.2 additional information the activin receptor-like kinase 1 gene is the second locus for the autosomal dominant vascular disease hereditary hemorrhagic telangiectasia 2.7.10.2 additional information signal transduction by TGF bet involves the formation of a heteromeric complex of two different serine/threonine kinase receptors 2.7.10.2 additional information involved in signal transduction 2.7.10.2 additional information insensitivity to anti-mullerian hormone is due to a mutation in the human anti-mullerian hormone receptor 2.7.10.2 additional information transforming growth factor-beta regulates cell cycle progression by a unique signaling mechanism that involves its binding to the type II TGF beta receptor and activation of type I 2.7.10.2 additional information the receptor controls dauer larva development 2.7.10.2 additional information importance of the function of activin receptor in the regulatory mechanism for body axis formation 2.7.10.2 additional information enzyme is involved in TGFbeta signaling 2.7.10.2 additional information enzyme can have a protein-protein interaction, through its putative SH3 binding site, with at least two intracellular SH3-containing proteins 2.7.10.2 additional information enzyme is involved in bone morphogenetic protein signaling 2.7.10.2 additional information mullerian inhibiting substance causes regression of the fetal Mullerian duct on binding a heteromeric complex of types I and II cell-surface receptors in the fetal urogenital ridge. The anti-mullerian hormone type II receptor provides specificity for mullerian inhibiting substance 2.7.10.2 additional information cell-surface receptor required for transduction of environmental signals into an appropriate developmental response, controls dauer larva development 2.7.10.2 additional information mRIP3 uses a novel mechanism to induce death 2.7.10.2 additional information RIP2 interacts with members of the TNFR-1 signaling complex, including inhibitor of apoptosis protein cIAP1 and with members of the TNFR-associated factor family, specifically TRAF1, TRAF5, and TRAF6, but not with TRAF2, TRAF3, or TRAF4 2.7.10.2 additional information CARDIAK may be involved in NF-kappa B/JNK signaling and in the generation of the proinflammatory cytokine IL-1 beta through activation of caspase-1 2.7.10.2 additional information in a cell cycle the wee1 kinase is phosphorylated at M-phase, phosphorylation occurs in the N-terminal domain resulting in inactivation of the kinase activity. The N-terminal domain, or the entire molecule is extensively phosphorylated by cdc2-cyclin B kinase 2.7.10.2 additional information blocks cell division when overexpressed in Hela cells 2.7.10.2 additional information activity of WEE1Hu is regulated by phosphorylation and proteolytic degradation, WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2 2.7.10.2 additional information down-regulation of Wee1-like kinase activity by phosphorylation at mitosis is a multistep process that occurs after other biochemical reactions have signaled the successful completion of S phase 2.7.10.2 additional information active c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly, c-Fes colocalization with microtubules in vivo requires the SH2 enzyme domain, implication in the differentiation of vascular, endothelial, myeloid, hematopoietic, and neuronal cells, overview 2.7.10.2 additional information ALK-MYH9 performs tyrosine autophosphorylation in vivo, but not in vitro, possible mechanism 2.7.10.2 additional information antagonistic regulation of swelling-activated Cl- current in rabbit ventricle by Src and EGFR protein tyrosine kinases, overview 2.7.10.2 additional information CX3CL1, i.e. fractalkine, only member of the delta subclass of chemokines, triggers PTK Syk activity in monocytes/macrophages localized in F-actin-enriched cell protrusions, which are formed due to CX3CL1 treatment and subsequent increase in F-actin, Syk deficiency results in strong impairment of RAW cell migration to CX3CL1, overview 2.7.10.2 additional information enzyme is involved in cell growth, differentiation, and apoptosis 2.7.10.2 additional information Fes tyrosine kinase promotes survival and terminal granulocyte differentiation of factor-dependent myeloid progenitors (32D) and activates lineage-specific transcription factors, e.g. CCAAT/enhancer-binding protein-alpha and STAT3, down-regulation of macrophage marker F4/80 2.7.10.2 additional information Fps/Fes and Fer protein-tyrosine kinases play redundant roles in regulating hematopoiesis 2.7.10.2 additional information Fps/Fes tyrosine kinase is involved in regulation of erythropoiesis and of myeloid differentiation and survival 2.7.10.2 additional information IP3 production in the hypersensitive response of lemon seedlings against Alternaria alternata involves active protein tyrosine kinases but not a G-protein, overview 2.7.10.2 additional information JAK2 is an important intracellular mediator of cytokine signalling, JAK2 deficiency may lead to hematologic cancers, and a number of immune diseases 2.7.10.2 additional information protein kinases and protein phosphatases regulate enzyme activities in the cell, overview 2.7.10.2 additional information protein tyrosine kinase-dependent modulation of voltage-dependent potassium channels by genistein in cardiac ventricular myocytes 2.7.10.2 additional information protein tyrosine kinases are involved in downstream signaling pathways, e.g. BCR/ABL kinase in the phosphatidylinositol 3'-kinase pathway, required for regulation of cell differentiation and cell cycle regulation, BCR/ABL and several other constitutive protein tyrosine kinases are activated in myeloid malignancies, overview, protein deregulation probable due to fusion gene formation because of chromosomal translocations or as distinct gain-of-function point mutations, autophosphorylation of BCR/ABL kinase at Tyr177 is essential for myeloid leukomogenesis in vivo, expression of BCR/ABL kinase leads to functional downregulation of the basal transcription factor TFIIH involved in nucleotide excision DNA repair pathway, and to activation of RAD51 also involved in DNA repair, overview 2.7.10.2 additional information protein tyrosine kinases are involved in downstream signaling pathways, e.g. BCR/ABL kinase in the phosphatidylinositol 3'-kinase pathway, required for regulation of cell differentiation and cell cycle regulation, expression of BCR/ABL kinase leads to functional downregulation of the basal transcription factor TFIIH involved in nucleotide excision DNA repair pathway, and to activation of RAD51 also involved in DNA repair, overview 2.7.10.2 additional information protein tyrosine kinases play a critical role in the modulation of a wide range of cellular events such as cell division, cell differentiation, and cell metabolism, over-stimulation of PTKs impairs normal cell growth, resulting in oncogenic transformation, regulation of enzyme activity occurs in dynamic oscillatory behaviour, patterns and mechanism, overview 2.7.10.2 additional information PTKs are involved in cell signalling 2.7.10.2 additional information spleen tyrosine kinase Syk modulates epidermal growth factor receptor EGFR signalling in mammary epithelial cells acting as a negative controle element, regulation of EGFR by activation of the autophosphorylation activity of EGFR, but not of HER2 and HER3, overview 2.7.10.2 additional information Src activates an outwardly rectifying chloride current in myocytes being involved in osmotic swelling, enzyme inhibition also inhibits stretch-activated Cl- current, mechanism, overview 2.7.10.2 additional information Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview 2.7.10.2 additional information Src family kinases Hck, Fyn and Src are constitutively expressed and are required for murine embryonic stem cell growth and differentiation, regulation of SFKs in response to leukemia inhibitory factor LIF and other growth factors, overview 2.7.10.2 additional information Src-dependent outside-in signalling is a key step in the process of autoregulation of beta2 integrins in polymorphonuclear cells and required for adhesion of interleukin-8, Src PTKs are required for macrophage antigen-1-mediated adhesion, which is inhibited by cytochalasin D and involved F-actin and protein P-110, overview 2.7.10.2 additional information Src-family protein tyrosine kinases are proto-oncogenic enzymes controlling mammalian cell growth and proliferation, the enzymes are regulated by activation through autophosphorylation of their kinase domain and by inhibition through phosphorylation of their regulatory tyrosine residue near the C-terminus, mechanism, overview, abberrant SFK activation contributes to cancer development 2.7.10.2 additional information Syk kinase is involved in cell motility and activation of phosphatidylinositol 3'-kinase, Syk kinase inhibits the tyrosine phosphorylation of IkappaBalpha and thus inhibits activation of NFkappaB via interaction of IkappaBalpha and phosphatidylinositol 3'-kinase, pathway regulation, overview 2.7.10.2 additional information Tec family tyrosine kinases play a central role in hematopoietic cellular signaling 2.7.10.2 additional information the enzyme is involved in regulation of sperm capacitation, signal transduction mechanism, capacitation mechanism, overview 2.7.10.2 additional information the enzyme is regulated in balance with protein tyrosine phosphatase, complex regulation mechanism, overview, the enzyme has decreasing effect, opposing to receptor protein tyrosine kinase EGFR, on volume-sensitive chloride current in atrial myocytes, overview 2.7.10.2 additional information the enzyme plays an important role in the self-renewal and as comitogen in the movement of stem cells out of the haematopoietic stem cell pool into the progeny pool, regulation of bone marrow cell migration 2.7.10.2 additional information the Fes tyrosine kinase is regulated via its SH2 domain 2.7.10.2 additional information the Janus kinase is involved in the JAK-STAT signaling cascade causing inflammatory activity in the brain 2.7.10.2 additional information the Src tyrosine kinase regulates and stimulates silica particle formation in epithelium which induces chemokine KIP-2 release activating the signaling cascade via phosphorylation of MAPK and ERK, overview 2.7.10.2 additional information the Src tyrosine kinase regulates and stimulates silica particle formation in lung epithelium which induces interleukin-8 release activating the signaling cascade via phosphorylation of MAPK and ERK, overview 2.7.10.2 additional information the Syk family tyrosine kinase ZAP-70 is required to couple the activated T-cell antigen receptor TCR to downstream signaling pathways, binding of TCR via its SH2 domains, regulation mechanism, overview 2.7.10.2 additional information Yes kinase is required during development, overview 2.7.10.2 additional information a multisite model for Fyn binding and regulation, overview, subtype-selective modulation by tyrosine phosphorylation/dephosphorylation provides a mechanism for differential regulation of sodium channels by neurotrophins and tyrosine phosphorylation in unmyelinated axons and dendrites, where NaV1.2 channels are expressed in brain neurons, overview 2.7.10.2 additional information Brutons tyrosine kinase is involved in B lymphocyte chemotaxis and homing, overview 2.7.10.2 additional information c-Abl activates p21 transcription via interaction with and regulation of the DNA-binding of p53, c-Abl also recruits p53 to the p21 promoter, overview 2.7.10.2 additional information c-Abl is regulated by conformational changes through intramolecular interactions and phosphorylation, overview 2.7.10.2 additional information c-Src is a physiologically relevant substrate for Methionine aminopeptidases, whose dysfunction is likely to account for the cell-cycle effects of MetAP inhibitors including bengamide A, overview 2.7.10.2 additional information Csk is essential for mouse embryonic development, Csk plays a role in G protein-coupled receptor- and receptor tyrosine kinase-induced fibroblast cell migration, overview, modeling of Csk regulation of focal adhesion turnover 2.7.10.2 additional information dynamics of BCR-ABL kinase domain mutations in chronic myeloid leukemia after sequential treatment with multiple tyrosine kinase inhibitors, overview 2.7.10.2 additional information enzyme deficiency leads to X-linked agammaglobulinemia, XLA, a humoral primary immunodeficiency in which affected patients have very low levels of peripheral B cells and a profound deficiency of all immunoglobulin isotypes, overview 2.7.10.2 additional information enzyme-deficient endothelial cells shows reduced migration, as well as decreased cell proliferation and survival in vivo 2.7.10.2 additional information Etk is essential for polymyxin resistance, while Wzc is not 2.7.10.2 additional information FAK plays a role in the anoikis phenomenon or anchorage-dependent cell survival, and in angiogenesis and formation of new blood vessels, overview, downstream targets of the FAK and PYK2 are MAP kinases implicated in proliferative processes, PYK2 is an essential linker between G-protein coupled receptor and the MAPK cascade, overview 2.7.10.2 additional information Fes is involved in the regulation of cell-cell and cell-matrix interactions mediated by adherens junctions and focal adhesions, the activated form of the kinase can induce cellular transformation, overview 2.7.10.2 additional information Fyn tyrosine kinase is involved in actin stress fiber formation in fibroblasts 2.7.10.2 additional information Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview 2.7.10.2 additional information p38 MAP kinase inhibitor SB203580 and protein tyrosine kinase inhibitor tyrphostin 25 combined can be used for inhibition of matrix metalloproteinase-9 expression, overview 2.7.10.2 additional information protein-tyrosine kinase Syk plays a central role in Fcgamma receptor-mediated phagocytosis in the adaptive immune system, and is required for pathogen engulfment in complement-mediated phagocytosis 2.7.10.2 additional information PYK2 is involved in vascular endothelial growth factor-induced activities, such as cell migration, blood vessel formation, Pyk2 forms complexes with Src tyrosine kinase for activation of the Akt tyrosine kinase pathway, PYK2 is required in receptor- and ischemia-activated signaling events leading to endothelial NO synthase phosphorylation and modulation of endothelial NO synthase-mediated vasoactive function and angiogenic response, PYK2 is involved in Ca2+ mobilization in muscle cells, overview 2.7.10.2 additional information spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1, neutrophil activation pathways, overview 2.7.10.2 additional information Src and Abl regulation, overview, cytoplasmic tyrosine kinase Src is involved in signal transduction induced by growth factors and integrins, Src also shows oncogenic activity when it is deregulated, Abl mediates Src-induced extracellular regulated kinase 5, ERK5, activation to drive cell transformation 2.7.10.2 additional information Src and Abl regulation, overview, cytoplasmic tyrosine kinase Src is involved in signal transduction induced by growth factors and integrins, Src also shows oncogenic activity when it is deregulated, Abl mediates Src-induced extracellular regulated kinase 5, ERK5, activation to drive cell transformation, Abl/Rac and Abl/ERK5 pathways also operate in human MCF7 and BT549 breast cancer cells, where neoplastic transformation depends on Src-like activities, overview 2.7.10.2 additional information Src PTK plays a role in NF-kappaB activation in epithelial cells, Src PTKs are important in regulation of vascular permeability and acute inflammatory responses, and are essential for the recruitment and activation of monocytes, macrophages, neutrophils, and other immune cells, Src PTKs can also regulate the functional activity of these receptors and is involved in cell signaling, biological functions, cellular and molecular mechanisms, overview 2.7.10.2 additional information Syk protein tyrosine kinase is involved in lipopolysaccharide-induced responses and intracellular signaling leading to release of pro-inflammatory mediators in macrophages, overview 2.7.10.2 additional information the BCR-ABL tyrosine kinase is inhibited in Philadelphia chromosome-positive chronic myeloid leukemia, CML, overview 2.7.10.2 additional information the Brutons tyrosine kinase is a critical signaling mediator downstream of the B cell Ag receptor, plays a role in regulating TLR-induced cytokine production, and is required for TLR-induced IL-10 production in multiple macrophage populations and in TLR signaling, overview, X-linked agammaglobulinemia is caused by mutations in Btk resulting in multiple defects in B cell development and function, and recurrent bacterial infections, Btk-dependent induction of NFkappaB and AP-1 DNA binding activity 2.7.10.2 additional information the enzyme is involved in cytokine signaling 2.7.10.2 additional information the enzyme tyrosine phosphorylates a wide range of proteins, especially nuclear matrix proteins 2.7.10.2 additional information the Src family of protein kinases mediates mitogenic signal transduction, and constitutive activation of the enzymes is associated with tumorigenesis 2.7.10.2 additional information the Src protein tyrosine kinase p56Lck plays a critical role in the O2 sensitivity of Kv1.3 channels and in signalling during hypoxia in T lymphocytes, overview 2.7.10.2 additional information the Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival, overview 2.7.10.2 additional information Toll-like receptors TLR-8 and TLR-9 require activation/phosphorylation by Btk for acting incell signaling, overview, enzyme deficiency is involved in development of male immune disorder X-linked agammaglobulineamia, XLA 2.7.10.2 additional information tyrosine kinase Fyn determines the specific localization of TrkB brain-derived neurotrophic factor, BDNF, receptor in to intracellular lipid rafts in cortical and hippocampal membranes, this process is critically dependent on the tyrosine kinase Fyn, overview, role for lipid rafts in neurotrophin signaling 2.7.10.2 additional information tyrosine kinase Fyn determines the specific localization of TrkB brain-derived neurotrophic factor, BDNF, receptor to intracellular lipid rafts in cortical and hippocampal membranes, this process is critically dependent on the tyrosine kinase Fyn, overview, role for lipid rafts in neurotrophin signaling 2.7.10.2 additional information tyrosine kinase Src is a key enzyme in mammalian signal transduction and an important target for anticancer drug discovery 2.7.10.2 additional information tyrosine kinases play a fundamental role in cell proliferation, survival, adhesion, and motility and have also been shown to mediate malignant cell transformation, Brk may play a key role in lymphomagenesis 2.7.10.2 additional information Lyn is an important B cell signaling kinase of the Src tyrosine kinase family with a broad range of functions from cytoskeletal changes to induction of apoptosis, Lyn and and its interaction with rafts and TLR2 are involved in the initial stages of Pseudomonas aeruginosa interaction with host cells and invasion of an alveolar epithelial cell line, primary lung cells, and rat lungs by Pseudomonas aeruginosa, overview 2.7.10.2 p130Cas + ATP phosphorylation of the Crk and Nck adaptor protein by Fak 2.7.10.2 paxillin + ATP phosphorylation at Tyr31 and Tyr118 by Fak plays a role in tumor cell motility inhibition 2.7.10.2 STAT transcription activator protein + ATP activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview 2.7.10.2 Wiskott-Aldrich syndrome protein + ATP i.e. WASP, phosphorylation by Fak