2.7.1.158 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP intermediate in both lipid-dependent and lipid-independent phytic acid biosynthetic pathways 2.7.1.158 1D-myo-inositol 1,4,6-trisphosphate + ATP relative substrate specificity 93.9% 2.7.1.158 ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - 2.7.1.158 ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate cytoplasmic production of 1D-myo-inositol hexakisphosphate is sufficient for mediating the Gle1-mRNA export pathway 2.7.1.158 ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate it is suggested that the enzyme is necessary for yolk sac development or function. Loss of inositol 1,3,4,5,6-pentakisphosphate 2-kinase is lethal 2.7.1.158 ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate the enzyme may be involved in both inositol hexakisphosphate formation in maturing seeds and ATP resynthesis in germinating seeds 2.7.1.158 ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate the product 1D-myo-inositol hexakisphosphate plays a role in messenger RNA export 2.7.1.158 ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate rate-determining step in production of 1D-myo-inositol hexakisphosphate 2.7.1.158 ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate the predominant activity of StITPK1 is that of an InsP5-ADP phosphotransferase. 2.7.1.158 additional information loss of the 2-kinase is lethal 2.7.1.158 additional information capable to catalyze the phosphorylation of myo-inositol 1,4,5,6-tetrakisphosphate (relative substrate specificity 76.8%), and myo-inositol 3,4,5,6-tetrakisphosphate (relative substrate specificity 32.6%) 2.7.1.158 additional information StITPK1 displays inositol 3,4,5,6-tetrakisphosphate 1-kinase activity. The enzyme displays inositol 1,3,4,5,6-pentakisphosphate 1-phosphatase activity in the absence of a nucleotide acceptor and inositol 1,3,4,5,6-pentakisphosphate-ADP phosphotransferase activity in presence of physiological concentrations of ADP. Additionally, StITPK1 shows inositol phosphate-inositol phosphate phosphotransferase activity.