2.4.1.47 additional information - 2.4.1.47 additional information final step of galactosylceramide synthesis, which plays a role in myelin formation, signal transduction and oligodendrocyte development 2.4.1.47 additional information key enzyme in the biosynthesis of cerebrosides and sulfatides, cell-specific and highly time-regulated expression of the CGT gene is thought to play an important role in oligodendrocyte and Schwann cell differentiation 2.4.1.47 additional information oligodendrocyte-specific enzyme is involved in the biosynthesis of the oligodendrocyte- and myelin-specific cerebrosides, time-regulated CGT expression with a peak around postnatal days 15-25 2.4.1.47 additional information last step in biosynthesis of cerebrosides 2.4.1.47 additional information enzyme ensures a supply of UDP-galactose in the endoplasmic reticulum lumen by retaining UDP-galactose transporter in a molecular complex 2.4.1.47 UDP-galactose + ceramide - 2.4.1.47 UDPgalactose + 2-(2-hydroxyacyl)sphingosine i.e. 2-hydroxy fatty acid ceramide, synthesis of cerebroside 2.4.1.47 UDPgalactose + 2-(2-hydroxyacyl)sphingosine enzyme may play an important role in the synthesis of at least one type of myelin 2.4.1.47 UDPgalactose + 2-(2-hydroxyacyl)sphingosine key enzymatic step in the biosynthesis of the galactocerebrosides, cell-specific and highly time-regulated expression of the CGT gene in the terminal differentiated oligodendrocytes of CNS and in Schwann cells of PNS 2.4.1.47 UDPgalactose + 2-(2-hydroxyacyl)sphingosine key enzyme in the biosynthesis of galactocerebroside, the most abundant glycosphingolipid in the myelin sheath