2.4.1.212	additional information	enzyme is responsible for hyaluronan biosynthesis, the hyaluronan capsule is an important, but not the only, virulence factor, physiological role of the enzyme	
2.4.1.212	additional information	isozyme expression and effects on tumor development and growth in rats, overview	
2.4.1.212	additional information	isozyme expression and effects on tumor development and growth in rats, overview, repression of HAS2 expression leads to reduced hyaluronan synthesis and reduced tumorigenicity in the peritoneum	
2.4.1.212	additional information	isozyme expression and regulation by interleukin-1beta, progesterone, and low-molecular-weight hyaluronan in pregnant mouse uterine cervix, overview	
2.4.1.212	additional information	regulation mechanism of hyaluronan biosynthesis, stimulation of cells by cytokines effects the different expression patterns of the isoforms, especially during embryonic development, the isozymes have different roles in hyaluronan biosynthesis	
2.4.1.212	additional information	regulation mechanism of hyaluronan biosynthesis, stimulation of cells by cytokines effects the different expression patterns of the isoforms, especially during embryonic development, the isozymes have different roles in hyaluronan biosynthesis, isozymes exhibit different functions in tumor growth, progression, and determination of malignancy	
2.4.1.212	additional information	the produced hyaluronan capsule enhances infection	
2.4.1.212	additional information	HA made by the has-1 transduced arterial smooth muscle cells is larger or part of a larger complex that resists proteolytic degradation when compared to the has-3 tansduced ASMCs. There is evidence that the different has enzymes have an inherent ability to regulate hyaluronan size	
2.4.1.212	additional information	hyaluronic acid synthase contributes to the pathogenesis of Cryptococcus neoformans infection	
2.4.1.212	additional information	HAS2, localized in the plasma membrane, uses cytoplasmic UDP-glucuronic acid and UDP-N-acetylglucosamine as substrates	
2.4.1.212	additional information	isozyme HAS1 requires higher cellular UDP-GlcNAc concentration than isozymes HAS2 and HAS3. HAS1 is almost inactive in cells with low UDP-sugar supply, HAS2 activity increases with UDP-sugars, and HAS3 produces hyaluronan at high speed even with minimum substrate content. HAS works on the cytosolic pool of the UDPsugars	
2.4.1.212	additional information	Pasteurella multocida hyaluronan synthase encompasses two transferase domains that elongate a growing hyaluronan oligosaccharide chain by addition of either GlcNAc or GlcUA residues from a corresponding UDP-sugar	
2.4.1.212	UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]	-	
2.4.1.212	UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]	-	
2.4.1.212	UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]	-	
2.4.1.212	UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan]	-	
2.4.1.212	UDP-N-acetyl-D-glucosamine + UDP-D-glucuronate	-	
2.4.1.212	UDP-N-acetyl-D-glucosamine + UDP-D-glucuronate	addition of monosaccharides to the linear heteropolysaccharide chain	
2.4.1.212	UDP-N-acetyl-D-glucosamine + UDP-D-glucuronate	addition of monosaccharides to the reducing end to form a linear heteropolysaccharide chain	
2.4.1.212	UDP-N-acetyl-D-glucosamine + UDP-D-glucuronate	biosynthesis of hyaluronan