2.3.1.B41	additional information	the enzyme preferentially hydrolyzes long-chain fatty acyl groups over acetyl groups in vitro	
2.3.1.B41	additional information	acetylation of nicotinamide phosphoribosyltransferase, i.e. NAMPT, on residue K53 by SIRT6	
2.3.1.B41	additional information	SIRT6 deacetylates Beclin-1 in HCC cells	
2.3.1.B41	additional information	SIRT6 is a specific deacetylase for H3K9, see EC 2.3.1.286. It also deacetylates H3K56 and H3K18, as well as KAP1, CtIP, PGC-1alpha, TRF2, GCN5, SNF2H, and PKM2	
2.3.1.B41	additional information	SIRT6 is a specific deacetylase for H3K9, see EC 2.3.1.286. It also deacetylates H3K56 and H3K18, as well as KAP1, CtIP, PGC-1alpha, TRF2, GCN5, SNF2H, and PKM2, cf. EC 2.3.1.286	
2.3.1.B41	additional information	sirtuin6 performs H3K9 acetylation on histone H3, cf. EC 2.3.1.286	
2.3.1.B41	NAD+ + [histone 3]-N6-palmitoyl-L-lysine	-	
2.3.1.B41	NAD+ + [histone H3 peptide]-N6-acetyl-L-lysine18	-	
2.3.1.B41	NAD+ + [histone H3 peptide]-N6-acetyl-L-lysine9	-	
2.3.1.B41	NAD+ + [histone H3]-N6-acetyl-L-lysine	-	
2.3.1.B41	NAD+ + [histone H3]-N6-acetyl-L-lysine18	-	
2.3.1.B41	NAD+ + [histone H3]-N6-acetyl-L-lysine56	-	
2.3.1.B41	NAD+ + [histone H3]-N6-acetyl-L-lysine9	-	
2.3.1.B41	NAD+ + [histone H3]-N6-palmitoyl-L-lysine9	-	
2.3.1.B41	NAD+ + [histone H4]-N6-acetyl-L-lysine	-	
2.3.1.B41	NAD+ + [Per2]-N6-acetyl-L-lysine	-	
2.3.1.B41	NAD+ + [protein]-N6-palmitoyl-L-lysine	-	
2.3.1.B41	NAD+ + [TNF-alpha]-N6-palmitoyl-L-lysine	-	
2.3.1.B41	NAD+ + [tumor necrosis factor alpha]-N6-acyl-L-lysine20	SIRT6 promotes the secretion of tumor necrosis factor alpha by removing the fatty acyl modification on K19 and K20 of TNFalpha