2.3.1.180 2-methylbutyryl-CoA + malonyl-[acyl-carrier protein] - 2.3.1.180 acetyl-CoA + a malonyl-[acyl-carrier protein] - 2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] - 2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] condensation of fatty acid synthase I-derived acyl-CoAs with malonyl-ACPs to initiates fatty acid synthase II-catalyzed fatty acid elongation, the enzyme links the two fatty acid synthase complexes 2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] FabH initiates the elongation of straight-chain fatty acids by the fatty acid synthase II complex, fatty acid synthesis pathway overview 2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] first condensing step in fatty acid synthase reaction, the enzyme is feedback regulated in biosynthesis of medium chain fatty acids 2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] initial condensation reaction to start fatty acid biosynthesis by the type II fatty acid synthase, the enzyme is a target for fatty acid synthesis regulation by acyl-[acyl-carrier-protein] 2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] regulation by feedback inhibition 2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] regulation of the enzyme activity is involved in regulation of fatty acid synthesis 2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] regulation of the enzyme activity is involved in regulation of the fatty acid synthesis 2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] the enzyme catalyzes the initial step in fatty acid biosynthesis via type II fatty acid synthase 2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] the enzyme initiates the fatty acid biosynthesis 2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] the enzyme initiates the fatty acid biosynthesis, overview 2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] the enzyme is essential for fatty acid biosynthesis, especially of short-chain fatty acids, by fatty acid synthase II initiating the elongation of fatty acids 2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] the enzyme is involved in initiation of fatty acid elogantion by the fatty acid synthase II catalyzing the decarboxylative condensation between malonyl-ACP and acetyl-CoA, the enzyme is essential for viability, overview 2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] FabH links FAS-I and FAS-II catalyzing the condensation of FAS-I-derived acyl-CoAs with malonyl-ACP 2.3.1.180 acyl-CoA + malonyl-[acyl-carrier protein] - 2.3.1.180 acyl-CoA + malonyl-[acyl-carrier protein] the condensation reaction is the first step in elongation in fatty acid synthesis by fatty acid synthase complex 2.3.1.180 butyryl-CoA + malonyl-[acyl-carrier protein] - 2.3.1.180 isobutyryl-CoA + malonyl-[acyl-carrier protein] - 2.3.1.180 isovaleryl-CoA + malonyl-[acyl-carrier protein] - 2.3.1.180 additional information fatty acid composition and acyl-ACP content in the leaves 2.3.1.180 additional information fatty acid composition and acyl-ACP content in the seeds 2.3.1.180 additional information fatty acid composition of wild-type and mutant strains, the latter expressing plasmid-encoded Escherichia coli or Streptomyces glaucescens enzymes, overview 2.3.1.180 additional information the enzyme is a key catalyst of fatty acid biosynthesis 2.3.1.180 additional information the enzyme is essential for fatty acid biosynthesis 2.3.1.180 additional information the enzyme is important in fatty acid biosynthesis 2.3.1.180 additional information the enzyme is involved in biosynthesis of straight-chain and branched-chain fatty acids with the specificity for acyl-CoA substrate determining the produced fatty acid spectrum 2.3.1.180 additional information the enzyme is not directly involved in tetracenomycin C biosynthesis 2.3.1.180 additional information the enzyme is responsible for the initiation of fatty acid biosynthesis and for viability 2.3.1.180 additional information the enzyme prefers short-chain CoA primer substrates 2.3.1.180 additional information the wild-type enzyme is able to induce synthesis of polyhydroxyalkanoates PHA copolymers from glucose in a strain which is transformed with gene phaC from Aeromonas caviae or gene phaC1 from Pseudomonas sp. strain 61-3, thus fatty acid biosynthesis may supply monomers for PHA production, overview 2.3.1.180 additional information beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria 2.3.1.180 additional information FabH catalyzes the initial step of fatty acid biosynthesis via a type II fatty acid synthase, FabH has an important role as essential enzyme combined with unique structural features and ubiquitous occurrence 2.3.1.180 additional information FabH is regulated by Ser/Thr protein kinase-dependent phosphorylation at Thr45, overview 2.3.1.180 myristoyl-CoA + malonyl-[acyl-carrier protein] the enzyme plays a key role in initiation of the long-chain fatty acid route of meromycolic acid biosynthesis, a different enzyme with specificity for short-chain acyl-CoAs might also be responsible for meromycolic acid biosynthesis, biosynthetic pathway regulation mechanism 2.3.1.180 propionyl-CoA + malonyl-[acyl-carrier protein] the enzyme specifies the propionate-starter unit for type II polyketide biosynthesis