2.1.1.86 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M - 2.1.1.86 5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulfonate involved in the formation of methane from CO 2.1.1.86 5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulfonate 2-mercaptoethanesulfonate i.e. coenzyme M. The enzyme uses the methylation of coenzyme M (HS-CoM) by methyl-tetrahydromethanopterin to drive an energy-conserving sodium ion pump 2.1.1.86 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M - 2.1.1.86 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + H+ - 2.1.1.86 5-methyl-5,6,7,8-tetrahydromethanopterin + CoM + 2 Na+/in - 2.1.1.86 5-methyl-5,6,7,8-tetrahydrosarcinapterin + coenzyme M -