1.17.4.2 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O - 1.17.4.2 additional information the two-component class II RNR is primarily used for DNA repair and/or possibly DNA replication at low oxygen tension. It can support bacterial growth in the absence of class I RNR activity 1.17.4.2 additional information p53-dependent small enzyme subunit M2B may play an important role for initiating DNA replication in normal growth 1.17.4.2 additional information the anaerobic ribonucleotide reductase of Escherichia coli is an essential enzyme required to supply the building blocks for DNA synthesis 1.17.4.2 additional information the enzyme produces deoxyribonucleotide triphosphates, dNTPs 1.17.4.2 additional information class II RNRs convert nucleoside triphosphates and nucleoside 5'-diphosphates, see also EC 1.17.4.1, to the correspondent 2'-deoxy products, overview 1.17.4.2 additional information class II RNRs convert nucleoside triphosphates and nucleoside 5'-diphosphates, see also EC 1.17.4.1, to the correspondent 2'deoxy products, overview 1.17.4.2 additional information RTPR catalyzes the conversion of nucleoside triphosphates to deoxynucleotides requiring adenosylcobalamin as a cofactor, model of reaction mechanism, overview 1.17.4.2 additional information RTPR catalyzes the conversion of nucleoside triphosphates to deoxynucleotides using adenosylcobalamin as a cofactor 1.17.4.2 additional information the small subunit of RNR2 interacts in planta with the C-terminal section of signalosome protein complex COP9 subunit 7, CSN7, overview 1.17.4.2 nucleoside 5'-triphosphate + formate class III RNR 1.17.4.2 nucleoside 5'-triphosphate + thioredoxin class II RNRs 1.17.4.2 nucleoside 5'-triphosphate + thioredoxin class III RNR 1.17.4.2 ribonucleoside triphosphate + reduced thioredoxin + H2O - 1.17.4.2 ribonucleoside triphosphate + reduced thioredoxin + H2O physiological hydrogen donor is unknown 1.17.4.2 ribonucleoside triphosphate + reduced thioredoxin + H2O catalyzes the rate-determining step in DNA biosynthesis 1.17.4.2 ribonucleoside triphosphate + reduced thioredoxin + H2O key enzyme in the pathway of DNA biosynthesis in all organisms 1.17.4.2 ribonucleoside triphosphate + thioredoxin -