1.14.19.1 additional information biosynthesis of unsaturated fatty acids. Possible substrates: acyl-CoA, acyl-acyl-carrier and acyl chains of phospholipids. The substrate in vivo is saturated phospholipid 1.14.19.1 additional information rate limiting-step in the cellular synthesis of monounsaturated fatty acids mainly oleate and palmitoleate 1.14.19.1 additional information key enzyme in the synthesis of unsaturated fatty acyl-CoAs 1.14.19.1 additional information rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids 1.14.19.1 additional information incorporation of the first unsaturation bond into saturated fatty acids 1.14.19.1 additional information long-chain polyunsaturated fatty acid biosynthetic pathway 1.14.19.1 additional information aging human orbitofrontal cortex includes decreasing of polyunsaturated fatty acid composition associates increases in lipogenic gene expression and stearoyl-CoA desaturase activity, overview 1.14.19.1 additional information Angus and Wagyu steers consuming high-roughage diets exhibit large differences in adipose tissue fatty acid composition, but there are no differences in terminal measures of CD activity or gene expression, overview 1.14.19.1 additional information decreased degradation of SCD is responsible for the increase in palmitoyl-CoA chain elongase activity in addition to increased transcription of SCD1 in the rats treated with clofibric acid, overview 1.14.19.1 additional information DesA3 is a membrane-bound stearoyl-CoA desaturase that works together with oxidoreductase Rv3230c, encoded by gene rv3230c, to produce oleic acid, an 55 essential constituent of mycobacterial membrane phospholipids and triglycerides 1.14.19.1 additional information due to a population-based, longitudinal cohort study of men, the risk of fracture is highest among men with the highest levels of SCD activity index, overview 1.14.19.1 additional information inhibition of the enzyme in cholesterol-fed hamsters leads to reduced overall body weight and adipose tissue deposition, while enzyme inhibition in absence of cholesterol does not. Enzyme inhibition induces hypercholesterinemia, overview 1.14.19.1 additional information role of SCD1 in fatty acid metabolism in HepG2 cells, the desaturation systems in Hep-G2 cells are strongly compartmentalized, effects of SCD1 inhibition on fatty acid composition in HepG2 cells occur through changes in the dynamics of the fatty acid metabolic network and not through transcriptional regulatory mechanisms, overview 1.14.19.1 additional information heterologous expression in yeast shows that Dpu-DELTA9-KPSE produces E9 mono-unsaturated fatty acids of various chain lengths. When provided with the (7Z)-tetradec-7-enoate, it forms the (7Z,9E)-tetradec-7,9-dienoate unsaturated fatty acids, another biosynthetic intermediate that can be chain-shortened to (5Z,7Z)-dodeca-5,7-dienoate 1.14.19.1 additional information enzyme SCD1 catalyzes the formation of a cis-double bond between the 9th and 10th carbons of stearoyl- or palmitoyl-CoA. The reaction requires molecular oxygen, which is activated by a diiron center, and cytochrome b5, which regenerates the di-iron center 1.14.19.1 additional information in addition to molecular oxygen, the SCD1 reaction requires NAD(P)H, cytochrome b5 reductase, and cytochrome b5 through which the electrons flow to SCD and then to molecular O2, which is reduced to H2O 1.14.19.1 additional information mouse SCD3 isoform preferentially catalyzes palmitoleate synthesis 1.14.19.1 additional information SCD1 catalyses the DELTA9 desaturation of 12-19 carbon saturated fatty acids to monounsaturated fatty acids 1.14.19.1 palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ - 1.14.19.1 palmitoyl-CoA + AH2 + O2 - 1.14.19.1 palmitoyl-CoA + ferrocytochrome b5 + O2 + 2 H+ a key step in triglyceride synthesis in the fatty acid metabolic network 1.14.19.1 stearate + AH2 + O2 - 1.14.19.1 stearate + AH2 + O2 biosynthesis of unsaturated fatty acid, synthesis of triacylglycerol from oleate 1.14.19.1 stearoyl-acyl-carrier protein + AH2 + O2 insertion of a cis double bond between the 9 and 10 position, essential step in fatty acid biosynthesis 1.14.19.1 stearoyl-acyl-carrier protein + AH2 + O2 key regulator of fatty acid desaturation of carbons 9 and 10 1.14.19.1 stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ - 1.14.19.1 stearoyl-CoA + AH2 + O2 - 1.14.19.1 stearoyl-CoA + AH2 + O2 also other fatty acyl-CoA substrates 1.14.19.1 stearoyl-CoA + AH2 + O2 oleic acid biosynthesis 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ - 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ a key step in triglyceride synthesis in the fatty acid metabolic network 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ essential enzyme activity, regulation mechanism, overview 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, deficiency of isozyme SCD1 leads to activation of the metabolic pathways that promote fatty acid beta-oxidation in mice, enzyme regulation in the heart in a hormone-dependent fashion, overview 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, hepatic SCD1 activity may regulate fat accumulation in the liver and possibly protects from insulin resistance in obesity, overview 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, it is also involved in familial combined hyperlipidemia, fatty acid desaturation index, overview 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, key enzyme in lipid metabolism and energy expenditure in mammals, overview 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, overview 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, which plays an important role in lipid metabolism and body weight control, overview 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ stearoyl-CoA desaturase 2 is uniquely and absolutely required for adipogenesis, SCD2 also controls the maintenance of adipocyte-specific gene expression in fully differentiated 3T3-L1 adipocytes, including the expression of SCD1, polysome profile analysis, overview 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ stearoyl-CoA desaturase converts saturated to monounsaturated fatty acids and is a key enzyme in lipogenesis, elevated levels of endogenous lipogenesis increase the risk of fracture and suggest a role for saturated fat in the pathogenesis of osteoporosis 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ the enzyme catalyzes the desaturation from saturated to monounsaturated fatty acids