1.1.1.140 D-fructose 6-phosphate + NADH - 1.1.1.140 D-fructose 6-phosphate + NADH + H+ - 1.1.1.140 D-sorbitol 6-phosphate + NAD+ - 1.1.1.140 D-sorbitol 6-phosphate + NAD+ hexitol catabolic enzyme 1.1.1.140 D-sorbitol 6-phosphate + NAD+ in the plant pathogen Erwinia amylovora the enzyme (S6PDH, SrlD) is used by the bacterium to utilize sorbitol, which is used for carbohydrate transport in the host plants belonging to the Amygdaloideae subfamily (e.g., apple, pear, and quince) 1.1.1.140 D-sorbitol 6-phosphate + NADP+ key enzyme in the regulation of the sorbitol/sucrose ratio in apple leaves