3.5.3.1	additional information	mitochondrial isoform arginase II negatively regulates NO synthase 1 activity by limiting substrate availability in its microdomain	
3.5.3.1	additional information	presence of arginine pools, which are accessible to NO synthase and enzyme, but not exchangeable	
3.5.3.1	additional information	the wild type enzyme does not hydrolyze 1-amino-4-guanidinobutane (agmatine)	
3.5.3.1	additional information	arginase II is constitutively expressed in the airways of normal mice, whereas arginase I is undetectable in normal airways, while its expression is increased in airways of mice exposed to ovalbumin	
3.5.3.1	additional information	complex regulation of natural killer cell functions by arginine availability	
3.5.3.1	additional information	hereditary defects in arginase compromise structure and catalysis, which results in an accumulation of arginine in the blood known as hyperarginemia. Arginase deficiency can also result in the accumulation of nitrogen in the form of ammonia, which results in hyperammonemia	
3.5.3.1	additional information	infection of mice with Schistosoma mansoni cercariae elevates arginase activity	
3.5.3.1	additional information	recombinant human arginase I (rhArg-PEG), an arginine-depleting enzyme, can inhibit the growth of arginine-dependent tumors