3.4.21.26	additional information	the enzyme plays a role in the metabolism of proline-containing neuropeptides which have been suggested to be involved in learning and memory processes	
3.4.21.26	additional information	the specificity for post-proline bonds suggests that the enzyme may play a central role in the hydrolysis of casein-derived bitter peptides, such as beta-casein(f193-209)	
3.4.21.26	additional information	tissue-dependent peptide hydrolysis evoked by prolyl endopeptidase activity is involved in the water-electrolyte homeostasis	
3.4.21.26	additional information	enzyme regulation, overview	
3.4.21.26	additional information	cellular functions, overview	
3.4.21.26	additional information	cellular functions, overview, POP may regulate phosphoinositide signaling, overview	
3.4.21.26	additional information	cellular functions, overview, POP may regulate phosphoinositide signaling, overview, the enzyme is involved in Alzheimer's disease with enzyme inhibition leading to a reduction of beta-amyloid peptide, overview	
3.4.21.26	additional information	cellular functions, overview, POP may regulate phosphoinositide signaling, overview, the enzyme is involved in neuronal degeneration and Alzheimer's disease with enzyme inhibition leading to a reduction of beta-amyloid peptide, overview	
3.4.21.26	additional information	enzyme inhibition leads to inhibition of lithium effects, the loss of enzyme activity evokes a 4fold increase in the inositol-3-phosphate concentration counteracting the Li+ ions, enzyme regulation, overview	
3.4.21.26	additional information	enzyme inhibitors are able to prevent the in vitro invasion of rodent muscle cells by trypomastigotes