3.4.15.1	Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O	i.e. substance P, lung and brain ACE cleave substance P via two pathways. In one pathway ACE first releases Gly-Leu-Met-NH2 and then dipeptides sequentially from the carboxyl terminus. The other first produces Leu-Met-NH2 and then releases dipeptides to leave substance P(1-5)	
3.4.15.1	bradykinin + H2O	-	
3.4.15.1	bradykinin + H2O	degradation	
3.4.15.1	bradykinin + H2O	inactivation	
3.4.15.1	bradykinin + H2O	bradykinin is a nonapeptide released from high molecular weight kininogen, it exerts its vasodilatory effect mainly by stimulation of B2 receptors	
3.4.15.1	additional information	-	
3.4.15.1	additional information	potential role of follicular enzyme in early stages of follicular maturation and atresia	
3.4.15.1	additional information	the enzyme enhances presentation of certain endogenously synthesized peptides to major histocompatibility complex class-I-restricted cytotoxic T-lymphocytes	
3.4.15.1	additional information	primary enzyme that is involved in the degradation of Tyr-Gly-Gly-Phe-Met-Arg-Gly-Leu in brain	
3.4.15.1	additional information	may contribute to elevated blood pressure in hypertensive disease via conversion of angiotensin I to angiotensin II or inactivation of bradykinin