4.2.99.18 Ca2+ optimal concentration at 5-30 mM, only 50% activity at 40 mM 648668 4.2.99.18 Ca2+ presence of 1 or 5 mM Ca2+ causes much less efficient stimulation of HpXth's AP site cleavage activity as compared to Mg2+ or Mn2+ 749127 4.2.99.18 Ca2+ stimulates 648635 4.2.99.18 Co2+ 0.1-1.0 mM, strong stimulation of all DNA repair activities 730783 4.2.99.18 Co2+ CoCl2 (500 microM) is essential for AP endonuclease assay. Effects of Co on APE/Ref-1 are concentration dependent 690475 4.2.99.18 Co2+ stimulation 648624 4.2.99.18 Cu2+ activates at 0.01 mM, inhibits at 0.1 mM 749127 4.2.99.18 Fe pro-inflammatory activity of iron in the lung injury, at least in part, because of its induction of APE/Ref-1 690475 4.2.99.18 Fe2+ 0.1-1.0 mM, strong stimulation of all DNA repair activities 730783 4.2.99.18 Fe2+ activates at 0.01 mM, inhibits at 0.1 mM 749127