4.2.3.127	Mg2+	dependent on, two consensus sequences - an aspartate rich DDXXD/E and a NSE/DTE motif - located at the entrance of the active site coordinate a trinuclear Mg2+ cluster. In reactions where Mg2+ is replaced with either Mn2+ or K+ is the disappearance of beta-copaene	714733	
4.2.3.127	Mg2+	required	713839	
4.2.3.127	Mg2+	required, enzyme CoTPS2 has the conserved aspartate-rich motif (DDXXD) and NSE/DTE motifs that chelate divalent metal ions, typically Mg2+, in the C-terminal domain	743000	
4.2.3.127	additional information	in presence of the divalent cation Mn2+, Cop4 favors a reaction path that ends after one cyclization in (-)-germacrene D	714733	
4.2.3.127	additional information	the enzyme contains the metal-binding DDXXD motif	713839