3.1.4.12 Ca2+ - 135188, 678083 3.1.4.12 Ca2+ activated by micromolar concentrations of Ca2+ (0.0001 or 0.00001 mM) under Mg2+-free conditions, ceramide generation is dependent upon the calcium ionophore A23187, nSMase is not activated by Ca2+ cations in the presence of 1 mM Mg2+ 705258 3.1.4.12 Ca2+ activation of hemolysis at 2 mM, strong inhibition at 10 mM 651708 3.1.4.12 Ca2+ Km: 0.0191 mM, activation of sphingomyelinase activity in the order of decreasing efficiency Co2+, Mn2+, Mg2+, Ca2+, Sr2+ 665716 3.1.4.12 Ca2+ lysosomal enzyme, stimulation at pH 5-7.5 135163 3.1.4.12 Ca2+ partly restores the EDTA-inhibited enzyme activity 135166 3.1.4.12 Ca2+ plays a role in enzyme regulation by non-substrate lipids 679082 3.1.4.12 Ca2+ slight activation when water-soluble substrates are used 135157 3.1.4.12 Ca2+ slightly activates, Km is 1.40 mM 730073 3.1.4.12 Cd2+ - 135148