4.1.99.16	Co2+	10-20% of the activity with Mg2+	680396	
4.1.99.16	Cu2+	10-20% of the activity with Mg2+	680396	
4.1.99.16	Fe2+	50% of the activity with Mg2+	680396	
4.1.99.16	Mg2+	each enzyme domain requires Mg2+ for catalysis, binding structure analysis at the N-terminal domain, overview	747096	
4.1.99.16	Mg2+	preferred divalent cation, maximum activity at 10 mM	680396	
4.1.99.16	Mn2+	10-20% of the activity with Mg2+	680396	
4.1.99.16	additional information	absolute requirement for a divalent cation. No activity with Ni2+ or Ca2+	680396	
4.1.99.16	Zn2+	50% of the activity with Mg2+	680396