1.14.11.6 Fe2+ - 439133, 439137, 439138, 439139, 439140, 439141, 439144, 439145, 439146 1.14.11.6 Fe2+ 4 residues within this motif are critical for the coordination of Fe2+ and 2-oxoglutarate binding as well as functionality of this family of enzymes 700501 1.14.11.6 Fe2+ acts as cofactor, 4 residues within this motif are critical for the coordination of Fe2+ and 2-oxoglutarate binding as well as functionality of this family of enzymes 700501 1.14.11.6 Fe2+ dependent on, required for catalysis 745921 1.14.11.6 Fe2+ non-heme 439134, 439135 1.14.11.6 additional information Ni2+ and Ca2+ cannot substitute for Fe2+, binding structure with truncated enzyme mutant. Residues His214, Asp216 and His271 play essential roles in the metal ion binding 745921