3.4.11.13 Cd2+ - 81194, 81195, 81196, 81197 3.4.11.13 Co2+ - 81197 3.4.11.13 Co2+ activates to a lesser extent than Mn2+, no activity in absence of metal ions 665095 3.4.11.13 Co2+ optiumum concentration 0.025 mM 81195, 81196 3.4.11.13 Co2+ required, 0.93-1.25 mol cobalt per mol enzyme, optimal concentration 0.003-0.018 mM, involved in enzyme-substrate binding, inhibitory above 3-7 mM, time-course of activation 81193 3.4.11.13 Mn2+ - 81197 3.4.11.13 Mn2+ activates, no activity in absence of metal ions 665095 3.4.11.13 Mn2+ best activator, optimum concentration 0.05 mM 81195, 81196 3.4.11.13 Mn2+ required 81193 3.4.11.13 Ni2+ - 81194, 81195, 81196, 81197