5.1.99.1	Mn2+	increases activity to a smaller extent than Co2+	2437	
5.1.99.1	Mn2+	lower level of activation than Co2+ at higher concentrations	2442	
5.1.99.1	Mn2+	presence of Mn2+ restores activity after incubation with EDTA	693174	
5.1.99.1	additional information	enzyme does not require tightly bound metal ions for activity, they are not released even after extensive dialysis at pH 2.4	2437	
5.1.99.1	additional information	His12, Gln65, His91 and Glu141 provide a binding site for a divalent metal ion, as shown by binding of Co2+	653930	
5.1.99.1	additional information	no activation of enzyme with Mg2+, Ni2+	693174	
5.1.99.1	Ni2+	activates	726729	
5.1.99.1	Ni2+	increases activity to a smaller extent than Co2+	2437	
5.1.99.1	Ni2+	the enzyme is activated by divalent cations (Ni2+, Co2+, and Mg2+)	726729	
5.1.99.1	Zn2+	increases activity to a smaller extent than Co2+	2437