7.2.2.8	apical plasma membrane	luminal acidification is required for the cell to redirect ATP7B to the apical domain and maintain it there under conditions of high Cu. Deacidification prevents Cu-directed delivery to apical domain	16324	735317	
7.2.2.8	endosome	Cu2+ directs ATP7B to the apical domain of hepatic cells via basolateral endosomes	5768	735317	
7.2.2.8	endosome	high Cu2+ concentration redistributes ATP7B to late endosomes or lysosomes that move along the axon in live hippocampal neurons	5768	734662	
7.2.2.8	Golgi apparatus	-	5794	751286	
7.2.2.8	Golgi apparatus	a second di-leucine motif in the carboxy tail of ATP7A (1459LL) is essential for steady-state localization in the trans-Golgi network by functioning in endosome-to-trans-Golgi network trafficking. Multiple di-leucine signals are required for recycling ATP7A from the plasma membrane to the trans-Golgi network	5794	751472	
7.2.2.8	intracellular	-	5622	-, 734718	
7.2.2.8	intracellular	TgCuTP localizes to intraparasitic structures juxtaposed to the acidocalcisomes and/or plant-like vacuole	5622	734718	
7.2.2.8	lysosome	high Cu2+ concentration redistributes ATP7B to late endosomes or lysosomes that move along the axon in live hippocampal neurons	5764	734662	
7.2.2.8	membrane	-	16020	-, 722821, 725389, 725999, 733703, 734282	
7.2.2.8	membrane	an integral membrane protein of cytoplasmic membranes	16020	-, 720396