3.4.23.38 membrane proplasmepsin I is a type II integral membrane protein that is transported though the secretory pathway before cleavage to the soluble form 16020 648184 3.4.23.38 vacuole - 5773 648180, 648184, 753556 3.4.23.38 vacuole digestive vacuole 5773 648179, 680251 3.4.23.38 vacuole the plasmepsins, although not essential, contribute significantly to the fitness of the parasite and are required for efficient degradation of endosomal vesicles delivered to the digestive vacuole 5773 682004