3.4.17.23 cell membrane - - 708649 3.4.17.23 cell surface - 9986 707074 3.4.17.23 cell surface cell-surface non-raft protein with the extracellular N-terminal and intracellular C-terminal domains. Binding to SARS-CoV-2 protein S induces the ACE2 internalization 9986 762787 3.4.17.23 cytoplasm - 5737 710171 3.4.17.23 cytoplasm ACE2 exists as bothmembrane bound and soluble forms, the latter being generated by proteolytic cleavage of the ectodomain by the tumor necrosis factor convertase ADAM17 5737 694170 3.4.17.23 membrane - 16020 658459, 659147, 679300, 679706, 679708, 680388, 710171 3.4.17.23 membrane ACE 2 is shedded 16020 707074 3.4.17.23 membrane ACE2 also undergoes phorbol-12-myristate-13-acetate-inducible ectodomain shedding from the membrane 16020 679705 3.4.17.23 membrane ACE2 exists as bothmembrane bound and soluble forms, the latter being generated by proteolytic cleavage of the ectodomain by the tumor necrosis factor convertase ADAM17 16020 694170 3.4.17.23 membrane ACE2 is a type I membrane-anchored protein with a catalytically active ectodomain, that undergoes shedding 16020 707055