2.3.1.286 cytoplasm - 5737 738942, 750703 2.3.1.286 cytoplasm the enzyme is cytoplasmic during most of the cell cycle except in the G2/M transition and in mitosis 5737 729802 2.3.1.286 mitochondrion - 5739 738108, 738661 2.3.1.286 mitochondrion SIRT3 is localized to the inner membrane of the mitochondria 5739 730840 2.3.1.286 mitochondrion Sirt5 can be translocated into the mitochondrial intermembrane space, but also into the matrix 5739 730205 2.3.1.286 nuclear body SIRT1 and p53 colocalize in nuclear bodies (punctate structures found in the nuclei of certain cells) upon upregulation of the promyelocytic leukemia protein 16604 729638 2.3.1.286 nucleus - 5634 750703 2.3.1.286 nucleus in the G2/M transition and in mitosis the enzyme is localized in association with chromatin 5634 729802 2.3.1.286 nucleus SIRT1 is located in the nucleus of cerebral cortex neurons 5634 730103