7.2.2.8 apical plasma membrane luminal acidification is required for the cell to redirect ATP7B to the apical domain and maintain it there under conditions of high Cu. Deacidification prevents Cu-directed delivery to apical domain 16324 735317 7.2.2.8 endosome Cu2+ directs ATP7B to the apical domain of hepatic cells via basolateral endosomes 5768 735317 7.2.2.8 endosome high Cu2+ concentration redistributes ATP7B to late endosomes or lysosomes that move along the axon in live hippocampal neurons 5768 734662 7.2.2.8 Golgi apparatus - 5794 751286 7.2.2.8 Golgi apparatus a second di-leucine motif in the carboxy tail of ATP7A (1459LL) is essential for steady-state localization in the trans-Golgi network by functioning in endosome-to-trans-Golgi network trafficking. Multiple di-leucine signals are required for recycling ATP7A from the plasma membrane to the trans-Golgi network 5794 751472 7.2.2.8 intracellular - 5622 -, 734718 7.2.2.8 intracellular TgCuTP localizes to intraparasitic structures juxtaposed to the acidocalcisomes and/or plant-like vacuole 5622 734718 7.2.2.8 lysosome high Cu2+ concentration redistributes ATP7B to late endosomes or lysosomes that move along the axon in live hippocampal neurons 5764 734662 7.2.2.8 membrane - 16020 -, 722821, 725389, 725999, 733703, 734282 7.2.2.8 membrane an integral membrane protein of cytoplasmic membranes 16020 -, 720396 7.2.2.8 membrane inner membrane 16020 750917 7.2.2.8 membrane integral membrane protein 16020 723738 7.2.2.8 microsome - - 680804, 712378 7.2.2.8 additional information copper regulates the intracellular localization of copper transporter ATP7B, transient interactions between the N-terminal metal-binding domains and modulated intracellular localization of ATP7B, molecular mechanism - 734282 7.2.2.8 additional information TgCuTP localizes in close proximity of the acidocalcisomes and/or plant-like vacuole in Toxoplasma gondii - 734718 7.2.2.8 plasma membrane - 5886 734282, 751708 7.2.2.8 plasma membrane enzyme localization at high copper concentration 5886 735317 7.2.2.8 plasma membrane enzyme localization at high copper concentration. Deacidification prevents Cu-directed delivery to apical domain 5886 735317 7.2.2.8 plasma membrane under basal Cu2+ conditions, ATP7B is localized to the trans-Golgi network and the plasma membrane of the soma and dendrites but not the axon 5886 734662 7.2.2.8 trans-Golgi network Cu2+-regulated, dileucine-dependent localization of ATP7B to the neuronal trans-Golgi network. Under basal Cu2+ conditions, ATP7B is localized to the trans-Golgi network and the plasma membrane of the soma and dendrites but not the axon. Addition of high Cu2+ concentrations cause loss of trans-Golgi network localization and somatodendritic polarity of ATP7B. ATP7B co-localizes with sigma1B, as well as with the endogenous gamma subunit at the trans-Golgi network 5802 734662 7.2.2.8 trans-Golgi network enzyme localization at low copper concentration 5802 735317 7.2.2.8 trans-Golgi network the dimeric structure is retained during ATP7B trafficking between the intracellular compartments 5802 751096 7.2.2.8 trans-Golgi network upon copper elevation, ATP7B moves from the trans-Golgi network to specialized vesicles, following copper depletion, ATP7B returns from vesicles to the trans-Golgi network 5802 734282 7.2.2.8 vesicle - 31982 735317 7.2.2.8 vesicle ATP7B incorporation into AP-1-containing clathrin-coated vesicles. Addition of high Cu2+ concentrations reduce ATP7B incorporation into AP-1-containing clathrin-coated vesicle 31982 734662 7.2.2.8 vesicle Cu induces an increase in the number of ATP7B vesicles, which traverse large basolateral endosomes en route to the apical domain 31982 735317 7.2.2.8 vesicle enzyme CuTP is predominantly located in vesicular bodies of the parasite 31982 -, 734718 7.2.2.8 vesicle upon copper elevation, ATP7B moves from the trans-Golgi network to specialized vesicles, following copper depletion, ATP7B returns from vesicles to the trans-Golgi network 31982 734282