6.3.4.10 chloroplast - 9507 1396 6.3.4.10 cytoplasm - 5737 701936, 706629 6.3.4.10 cytoplasm localizes predominantly in the cytoplasm 5737 726859 6.3.4.10 cytosol - 5829 1389, 1390, 1395, 1396 6.3.4.10 mitochondria - - 701936 6.3.4.10 mitochondrion - 5739 1389, 1396, 701936 6.3.4.10 additional information HCS co-localizes with histone H3 in human cells with physical interactions between HCS and H3. The N-terminal and C-terminal domains in HCS participate in H3 binding - 715997 6.3.4.10 additional information isozyme subcellular localization, immunofluorescence study, overview - 701936 6.3.4.10 nucleus - 5634 706629, 726859 6.3.4.10 nucleus HCS migrates to the nucleus at the gastrulation stage. In polytene chromosomes, it is associated to heterochromatin bands where it co-localizes with histone 3 trimethylated at lysine 9 but not with the euchromatin mark histone 3 acetylated at lysine 9. HCS associates with the hsp70 promoter. On heat-shock activation of the hsp70 promoter, HCS is displaced and the promoter region becomes enriched with the TFIIH subunits XPD and XPB and elongating RNA pol I 5634 716237 6.3.4.10 nucleus the longer Met58 isoform 5634 701936