3.4.23.38 membrane proplasmepsin I is a type II integral membrane protein that is transported though the secretory pathway before cleavage to the soluble form 3.4.23.38 vacuole - 3.4.23.38 vacuole digestive vacuole 3.4.23.38 vacuole the plasmepsins, although not essential, contribute significantly to the fitness of the parasite and are required for efficient degradation of endosomal vesicles delivered to the digestive vacuole