2.7.1.67 AP-3 adaptor complex phosphatidylinositol-4-kinase type II alpha is a component of 30123 662815 2.7.1.67 chromaffin granule - 42583 641782, 641800, 641812 2.7.1.67 cytoplasm - 5737 723072, 759796, 760009 2.7.1.67 cytoplasm neuronal cells 5737 641806 2.7.1.67 cytoplasmic membrane - - 759796 2.7.1.67 cytosol - 5829 641774, 672995, 675000 2.7.1.67 cytosol enzyme form cPIK-I and cPIK-II 5829 641801 2.7.1.67 cytosol isozyme PI4KIIbeta 5829 721967 2.7.1.67 cytosol isozyme PI4KIIbeta is distributed almost evenly between membranes and cytosol 5829 722700 2.7.1.67 cytosol PI4KIIbeta is primarily cytosolic and it associates peripherally with plasma membranes, endoplasmic reticulum and the Golgi apparatus 5829 641813 2.7.1.67 endoplasmic reticulum - 5783 723072, 723790, 723791, 738939 2.7.1.67 endoplasmic reticulum at Golgi-endoplasmic reticulum contact points 5783 723791 2.7.1.67 endoplasmic reticulum highly active pool of type II phosphatidylinositol 4-kinase is localized in a p97/valosin-containing-protein-rich fraction of the endoplasmic reticulum 5783 641809 2.7.1.67 endoplasmic reticulum isozyme PI4KIIIalpha 5783 721967 2.7.1.67 endoplasmic reticulum PI4KIIIalpha 5783 722857 2.7.1.67 endosome - 5768 -, 674999, 722121, 723136, 723790, 759289, 759590 2.7.1.67 endosome dynamic tubular, PI4KII 5768 722098 2.7.1.67 endosome endosome 5768 641814 2.7.1.67 endosome isoozyme PI4KIIalpha 5768 723138 2.7.1.67 extrinsic to membrane PI4KIIalpha normally present both in perinuclear and peripheral organelles is substantially decreased in the peripheral membranes of AP-3-deficient mocha fibroblasts - 662815 2.7.1.67 Golgi apparatus - 5794 674573, 674704, 674715, 675000, 675016, 676001, 677233, 723136, 723790, 759590, 759678, 760185 2.7.1.67 Golgi apparatus at Golgi-endoplasmic reticulum contact points 5794 723791 2.7.1.67 Golgi apparatus isozyme PI4KIIIbeta is recruited to and principally localizes to the Golgi complex through GTP-bound Arf1 binding 5794 721967 2.7.1.67 Golgi apparatus isozyme Pik1 5794 722704 2.7.1.67 Golgi apparatus PI4KII 5794 722098 2.7.1.67 Golgi apparatus PI4KIIalpha colocalizes with markers of the trans-Golgi network 5794 662328 2.7.1.67 Golgi apparatus PI4KIIalpha is primarily Golgi-associated. Platelet-derived growth factor promotes PI4KIIbeta recruitment to membrane ruffles 5794 641813 2.7.1.67 Golgi apparatus PI4KIIIalpha 5794 722857 2.7.1.67 Golgi apparatus PI4KIIIbeta is enriched in early Golgi compartments 5794 662328 2.7.1.67 Golgi apparatus principal PI4Ks of the Golgi apparatus are PI4KIIalpha and PI4KIIIbeta 5794 723791 2.7.1.67 Golgi apparatus PtdIns 4-kinase Pik1 5794 -, 722789 2.7.1.67 Golgi membrane - 139 723136 2.7.1.67 Golgi membrane isozyme PI4KIIIbeta 139 723138, 723609 2.7.1.67 Golgi membrane isozyme Pik1 139 722704 2.7.1.67 lysosomal membrane - 5765 641789 2.7.1.67 lysosome membrane 5764 641789 2.7.1.67 membrane - 16020 641768, 641771, 641776, 641778, 641792, 641797, 641812, 676541, 723138, 723791, 739027 2.7.1.67 membrane associated 16020 641783, 641785 2.7.1.67 membrane bound to 16020 641794, 641798, 641800, 641802 2.7.1.67 membrane enzyme form mPIK-I and mPIK-II 16020 641801 2.7.1.67 membrane firmly associated with plasma membrane 16020 641815 2.7.1.67 membrane integral membrane protein 16020 641788, 641800 2.7.1.67 membrane isozyme PI4KIIalpha exists almost exclusively as a constitutively active integral membrane protein because of its palmitoylation 16020 722700 2.7.1.67 membrane isozyme PI4KIIbeta is distributed almost evenly between membranes and cytosol 16020 722700 2.7.1.67 membrane isozyme Pik1 16020 722704 2.7.1.67 membrane PI4K230 is distributed evenly on membranes that are ultra structurally cisterns of the rough endoplasmic reticulum, outer membranes of mitochondria, multivesicular bodies and are in close vicinity of synaptic contacts 16020 641806 2.7.1.67 membrane type II enzyme is almost exclusively found in membrane fraction 16020 641812 2.7.1.67 membrane type II PI 4-kinase enzymes 16020 721555 2.7.1.67 membrane vacuolar 16020 660950 2.7.1.67 microsome - - 641769, 641783, 641791, 641814 2.7.1.67 mitochondrial outer membrane - 5741 723790 2.7.1.67 additional information no or minimal activity can be ascribed to mitochondria, lysosomes, Golgi membranes or endoplasmic reticulum - 641790 2.7.1.67 additional information phosphatidylinositol 4-phosphate localization has a distinct pattern in cells infected with hepatitis C virus (extensive cytoplasmic distribution) compared to uninfected cells - 723072 2.7.1.67 additional information PI4KII localizes to the Golgi and to a dynamic tubular endosomal network - 722098 2.7.1.67 additional information Rac regulates PI4KIIbeta membrane recruitment - 723790 2.7.1.67 additional information whereas the palmitoylated membrane-bound pool is catalytically active, the cytosolic kinase is inactive - 722700 2.7.1.67 nucleolus - 5730 673232 2.7.1.67 nucleolus enzyme PI4K230 5730 641806 2.7.1.67 nucleus - 5634 641805, 662073, 674573, 675000, 739269 2.7.1.67 nucleus enzyme form PI4K92 5634 641806 2.7.1.67 nucleus PI4KIIIbeta shuttles through the nucleus 5634 723791 2.7.1.67 nucleus Pik1 shuttles through the nucleus. Nuclear accumulation of Pik1 is promoted by nutrient, e.g. glucose, deprivation, a condition that also results in the release of PI4K effectors from Golgi membranes and slowing of the rate of secretion 5634 723791 2.7.1.67 nucleus PtdIns 4-kinase Pik1 5634 -, 722789 2.7.1.67 nucleus the chilli leaf curl virus Rep protein directly interacts with PI4KII protein and influences nuclear occurrence of the enzyme 5634 759796 2.7.1.67 phagosome - - 760073 2.7.1.67 plasma membrane - 5886 641772, 641781, 641790, 641796, 660950, 662814, 676179, 677233, 723790 2.7.1.67 plasma membrane formyl associated with plasma membrane 5886 641815 2.7.1.67 plasma membrane isozyme PI4KIIIalpha 5886 723609 2.7.1.67 plasma membrane PtdIns 4-kinase Stt4 5886 -, 722789 2.7.1.67 plasma membrane type II PI 4-kinase enzymes 5886 721555 2.7.1.67 soluble - - 641784, 641804 2.7.1.67 trans-Golgi network - 5802 723790, 760068 2.7.1.67 transport vesicle glucose-transporter 30133 641796 2.7.1.67 vacuole - 5773 -, 759289 2.7.1.67 vesicle - 31982 673414 2.7.1.67 vesicle exocytotic vesicle 31982 673995 2.7.1.67 vesicle intracellular, isozyme PI4KIIbeta 31982 721967 2.7.1.67 vesicle specifically targeted to cellugyrin-positive glucose transporter 4 vesicles 31982 676001