2.5.1.6	cytoplasm	isoform MAT I, presence of two partially overlapping areas at the C-terminal end of the protein involved both in cytoplasmic retention and nuclear localization	
2.5.1.6	cytosol	-	
2.5.1.6	cytosol	S-adenosylmethionine synthetase A	
2.5.1.6	cytosol	S-adenosylmethionine synthetase B	
2.5.1.6	nucleus	isoform MAT I, in extrahepatic tissues, the protein colocalizes with nuclear matrix markers. Presence of two partially overlapping areas at the C-terminal end of the protein involved both in cytoplasmic retention and nuclear localization. Neither nuclear localization nor matrix binding requires activity. Nuclear accumulation of the active enzyme only correlates with histone H3K27 trimethylation among the epigenetic modifications evaluated