3.1.4.17 additional information - additional information - 135214, 135225, 135228, 135232, 135234, 135240, 135271, 135279, 667909 3.1.4.17 additional information - additional information biphasic behaviour with 3',5'-cAMP as substrate 135278 3.1.4.17 additional information - additional information three isoenzymes 135276 3.1.4.17 0.00002 - 3',5'-cGMP - 135219 3.1.4.17 0.000079 - 3',5'-cAMP isoform PDE3A-94 669403 3.1.4.17 0.000088 - 3',5'-cAMP isoform PDE3A-136 669403 3.1.4.17 0.000093 - 3',5'-cAMP isoform PDE3A-118 669403 3.1.4.17 0.000094 - 3',5'-cAMP 30°C, pH 8.0, PDE3A 649785 3.1.4.17 0.0001 - 3',5'-cAMP - 135232 3.1.4.17 0.0001 - 3',5'-cGMP - 135265 3.1.4.17 0.00018 - 3',5'-cAMP - 135219 3.1.4.17 0.0002 - 3',5'-cAMP - 135272 3.1.4.17 0.0002 - cGMP isoform PDE3, 22°C, pH 7.0 678053 3.1.4.17 0.00023 - cAMP pH 7.5, 30°C 654017 3.1.4.17 0.00024 - 3',5'-cAMP 30°C, pH 8.0, PDE3A 649785 3.1.4.17 0.00029 - 3',5'-cAMP 30°C, pH 8.0, PDE3B 649785 3.1.4.17 0.00047 - 3',5'-cAMP 30°C, pH 8.0, PDE3B 649785 3.1.4.17 0.00075 - cAMP isoform PDE1, 22°C, pH 7.0 678053 3.1.4.17 0.0009 - 3',5'-cAMP - 668133 3.1.4.17 0.00097 - 3',5'-cGMP 30°C, pH 7.5, PDE11A4 668990 3.1.4.17 0.0012 - cGMP brain 63 kDA isozyme 651468 3.1.4.17 0.0013 - cGMP isoform PDE1C, pH 7.4 679784 3.1.4.17 0.0013 0.0016 cGMP - 651105 3.1.4.17 0.0014 - 5'-AMP PdeB, in 50 mM Tris-HCl, pH 8.0, 0.05 mM MnCl2, at 40°C 692369 3.1.4.17 0.0016 - 5'-AMP PdeA, in 50 mM Tris-HCl, pH 8.0, 0.05 mM MnCl2, at 40°C 692369 3.1.4.17 0.0017 - cAMP isoform PDE1C, pH 7.4 679784 3.1.4.17 0.0018 - 3',5'-cAMP - 135213 3.1.4.17 0.002 - 3',5'-cGMP - 135213 3.1.4.17 0.002 0.004 cAMP - 651105 3.1.4.17 0.0023 - 3',5'-cGMP - 668133 3.1.4.17 0.0024 - 3',5'-cAMP 30°C, pH 7.5, PDE11A4 668990 3.1.4.17 0.0027 - cGMP brain 60 kDA isozyme 651468 3.1.4.17 0.0028 - cGMP lung isozyme 651468 3.1.4.17 0.003 - 3',5'-cAMP isoform PdeA, pH and temperature not specified in the publication 750557 3.1.4.17 0.0032 - cGMP heart isozyme 651468 3.1.4.17 0.0033 - 3',5'-cAMP PdeA, in 50 mM Tris-HCl, pH 8.0, 0.05 mM MnCl2, at 40°C 692369 3.1.4.17 0.0033 - 5'-ATP PdeB, in 50 mM Tris-HCl, pH 8.0, 0.05 mM MnCl2, at 40°C 692369 3.1.4.17 0.0033 - cAMP pH 7.5 653640 3.1.4.17 0.0037 - cGMP pH 7.5 653640 3.1.4.17 0.0038 - 2',3'-cAMP PdeA, in 50 mM Tris-HCl, pH 8.0, 0.05 mM MnCl2, at 40°C 692369 3.1.4.17 0.0042 - cGMP pH 7.5 653640 3.1.4.17 0.005 - 3',5'-cAMP isoform PdeB, pH and temperature not specified in the publication 750557 3.1.4.17 0.005 - 3',5'-cAMP PdeB, in 50 mM Tris-HCl, pH 8.0, 0.05 mM MnCl2, at 40°C 692369 3.1.4.17 0.005 - 3',5'-cGMP - 135218 3.1.4.17 0.005 - cAMP isoform PDE2, 22°C, pH 7.0 678053 3.1.4.17 0.0052 - 2',3'-cAMP PdeB, in 50 mM Tris-HCl, pH 8.0, 0.05 mM MnCl2, at 40°C 692369 3.1.4.17 0.0057 - cAMP pH 7.5 653640 3.1.4.17 0.006 - 3',5'-cGMP PDE11 667501 3.1.4.17 0.007 - 3',5'-cAMP pH and temperature not specified in the publication 750557 3.1.4.17 0.0075 - 3',5'-cAMP two forms of phosphodiesterase 135240 3.1.4.17 0.0088 - 3',5'-cGMP - 135278 3.1.4.17 0.012 - adenosine 3',5'-cyclic phosphate pH 7.0, 55°C 715378 3.1.4.17 0.012 - cAMP brain 63 kDA isozyme 651468 3.1.4.17 0.0125 - 5'-ATP PdeA, in 50 mM Tris-HCl, pH 8.0, 0.05 mM MnCl2, at 40°C 692369 3.1.4.17 0.0125 - cAMP isoform PDE7, 22°C, pH 7.0 678053 3.1.4.17 0.015 - 3',5'-cGMP - 135225 3.1.4.17 0.0153 - 3',5'-cGMP PDE1 667501 3.1.4.17 0.01797 - 3',5'-cGMP pH and temperature not specified in the publication 750418 3.1.4.17 0.0185 - 3',5'-cAMP PDE11 667501 3.1.4.17 0.01942 - 3',5'-cAMP pH and temperature not specified in the publication 750418 3.1.4.17 0.0205 - 3',5'-cAMP PDE1 667501 3.1.4.17 0.025 - guanosine 3',5'-cyclic phosphate pH 7.0, 55°C 715378 3.1.4.17 0.03 - 3',5'-cAMP - 135218 3.1.4.17 0.03 - 3',5'-cGMP soluble enzyme 135217 3.1.4.17 0.0316 - 3',5'-cAMP - 668560 3.1.4.17 0.032 - 3',5'-cAMP catalytic domain of PDE2A (PDE2A residues 578-919), enzyme expressed in Escherichia coli 667684 3.1.4.17 0.033 - 3',5'-cAMP - 135225 3.1.4.17 0.034 - 3',5'-cGMP catalytic domain of PDE2A (PDE2A residues 578-919), enzyme expressed in Escherichia coli 667684 3.1.4.17 0.035 - cAMP brain 60 kDA isozyme 651468 3.1.4.17 0.04 - cAMP heart isozyme 651468 3.1.4.17 0.042 - cAMP lung isozyme 651468 3.1.4.17 0.045 - 3',5'-cAMP pH and temperature not specified in the publication 750557 3.1.4.17 0.0464 - 3',5'-cAMP 30°C, pH 8.0, PDE2 649785 3.1.4.17 0.0464 - 3',5'-cGMP 30°C, pH 8.0, PDE1 649785 3.1.4.17 0.0773 - 3',5'-cAMP pH 7.5, 22°C, presence of 1 mM EDTA 729263 3.1.4.17 0.0782 - 3',5'-cGMP - 668560 3.1.4.17 0.09 - 3',5'-cAMP particulate enzyme 135217 3.1.4.17 0.095 - 3',5'-cAMP two forms of phosphodiesterase 135240 3.1.4.17 0.0968 - 3',5'-cGMP pH 7.5, 22°C, presence of 10 mM MgCl2 729263 3.1.4.17 0.0988 - 3',5'-cAMP pH 7.5, 22°C, presence of 10 mM MgCl2 729263 3.1.4.17 0.1 - 3',5'-cGMP particulate enzyme 135217 3.1.4.17 0.1047 - 3',5'-cGMP pH 7.5, 22°C 729263 3.1.4.17 0.1048 - 3',5'-cGMP pH 7.5, 22°C, presence of 10 mM ZnCl2 729263 3.1.4.17 0.11 - 3',5'-cAMP pH 7.5, 22°C 729263 3.1.4.17 0.1157 - 3',5'-cAMP pH 7.5, 22°C, presence of 10 mM ZnCl2 729263 3.1.4.17 0.1175 - 3',5'-cAMP pH 7.5, 22°C, presence of 10 mM MnCl2 729263 3.1.4.17 0.125 - 3',5'-cAMP soluble enzyme 135217 3.1.4.17 0.15 - 3',5'-cAMP - 667641 3.1.4.17 0.1539 - 3',5'-cGMP pH 7.5, 22°C, presence of 1 mM EDTA 729263 3.1.4.17 0.1913 - 3',5'-cGMP pH 7.5, 22°C, presence of 10 mM MnCl2 729263 3.1.4.17 0.204 - 5'-pApA pH 8.5, 23°C 749385 3.1.4.17 0.34 - cGMP isoform PDE11A2 678221 3.1.4.17 0.35 - 3',5'-cAMP pH and temperature not specified in the publication 750557 3.1.4.17 0.355 - 5'-pApG pH 8.5, 23°C 749385 3.1.4.17 0.4 - cGMP isoform PDE11A1 678221 3.1.4.17 0.45 - cAMP isoform PDE11A1 678221 3.1.4.17 0.45 - cAMP isoform PDE11A2 678221 3.1.4.17 0.8 - cAMP isoform PDE11A3 678221 3.1.4.17 0.8 - cGMP isoform PDE11A3 678221 3.1.4.17 1 - cGMP isoform PDE11A4 678221 3.1.4.17 1.23 - 3',5'-cGMP apparent value, at pH 7.5 and 30°C 751582 3.1.4.17 1.6 - cAMP isoform PDE11A4 678221 3.1.4.17 2.54 - 3',5'-cAMP apparent value, at pH 7.5 and 30°C 751582 3.1.4.17 6.82 - 3',5'-cAMP pH 7.5, 30°C 728995 3.1.4.17 7 - 3',5'-cAMP - 135254 3.1.4.17 12.82 - 3',5'-cGMP pH 7.5, 30°C 728995