3.1.3.67	4-hydroxynonenal	-	2131	
3.1.3.67	Ca2+	in presence of 1 mM Mg2+, slight activation up to 0.01 mM, significant inhibition above 0.1 mM	15	
3.1.3.67	H2O2	H2O2 reversibly inhibits PTEN activity by covalently linking Cys-71 to Cys-124, inhibition partially reverses by inclusion of 100 mM dithiothreitol to the buffer	22	
3.1.3.67	Laminin	laminin medium induces PTEN upregulation decreases transcription factor Sp1-binding activity	21030	
3.1.3.67	Mg2+	divalent cation required, maximal activition at 1 mM, inhibition above 1 mM	6	
3.1.3.67	additional information	PTEN is inhibited by cyclic strain: cyclic strain increases phosphatidylinositol 3,4,5-trisphosphate immunofluorescence and peaks at 60 min after cyclic strain stimulation by 1.93fold in endothelial cells	2	
3.1.3.67	additional information	PTEN function is very frequently lost during the development of epithelial-derived tumors, and many such tumors are believed to undergo a form of epithelial to mesenchymal transition before these metastasize	2	
3.1.3.67	phosphatidylserine	0.2 mM, 75% loss of activity	430	
3.1.3.67	reactive oxygen species	oxidation of the active site cysteine by reactive oxygen species inhibits PTEN	5795