2.7.7.4 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid - 256889 2.7.7.4 3',5'-adenosine diphosphate - 33051 2.7.7.4 3'-phosphoadenosine 5'-phosphosulfate allosteric, binding of the inhibitor to the catalytic site as well as to the allosteric site of the wild type enzyme acts to decrease the degree of cooperativity 2171 2.7.7.4 3'-phosphoadenosine-5'-phosphate strong 7470 2.7.7.4 3'-phosphoadenosine-5'-phosphate - 7470 2.7.7.4 3'-phosphoadenosine-5'-phosphate allosteric 7470 2.7.7.4 3'-phosphoadenosine-5'-phosphosulfate - 3782 2.7.7.4 3,5-di-tert-butyl-4-hydroxytoluene - 256890 2.7.7.4 3-tert-butyl-4-hydroxyanisole ligand diffuses through the gate formed by residues Glu332, Thr312 and His290 to the outside of enzyme. When the gate opens, the ligand is expelled from active site of enzyme, thereafter the ligand returns when the gate closes and binds itself in another region of active site nearby the zinc atom 188709 2.7.7.4 5,5'-dithiobis(2-nitrobenzoic acid) 0.05 mM, rapid decrease in activity of wild-type enzyme (t1/2: 20 s), truncated enzyme del396-573 retains more than 97% of its activity after 30 min 221