2.7.11.7 Ca2+/calmodulin no inhibition 3111 2.7.11.7 Ca2+/calmodulin weak 3111 2.7.11.7 Ca2+/calmodulin binds to the enzyme and inhibits its activation by acidic phospholipids but not by guanosine 5'-3-O-(thio)triphosphate-Rac1 3111 2.7.11.7 Ca2+/calmodulin calmodulin-binding site: amino acid residues 51-80; competes with phospholipids 3111 2.7.11.7 EGTA no inhibition 173 2.7.11.7 EGTA - 173 2.7.11.7 heparin - 227 2.7.11.7 histone - 1017 2.7.11.7 KCl strong, 90% inhibition at 60 mM, complete inhibition at 100 mM 79 2.7.11.7 KCl 80% inhibition at 90 mM 79