3.4.22.51	additional information	pro-region of the trypanosomal enzyme inhibits the enzyme function, cystatins and kininogens are inhibitors, overview: inhibitors	2	
3.4.22.51	additional information	in general immunoglobulin G fractions isolated from rabbits immunised with rabbit apha2-macroglobulin-recombinant catalytic domain of congopain-complexes are the most inhibitory towards the proteolytic activity of congopain. Antibodies produced by rabbits immunised with recombinant catalytic domain of congopain in Freund's adjuvant are generally found to weakly inhibit congopain with a maximum of 40%	2	
3.4.22.51	additional information	synthesis of 2-hydrazolyl-4-thiazolidinones based on multicomponent reactions and biological evaluation against Trypanosoma cruzi, inhibitory potencies and cytotoxic effects, molecular modeling and QSAR studies, overview. No inhibition by (RS)-2-(2-(2-bromobenzylidene)hydrazono)-3-methyl-4-oxo-5-thiazolidine-N-methylacetamide and (Z)-((2-(4-fluorobenzylidene)hydrazono)-3-methyl-5-methoxycarbonylmethylene)thiazolidin-4-one at 0.1 mM	2	
3.4.22.51	additional information	synthesis and inhibitory effects against cruzipaon of a series of thirty-three chalcone and seven hydrazide derivatives, overview	2	
3.4.22.51	additional information	AM1 semi-empirical molecular modeling studies analysing cruzain inhibitory activity, overview	2	
3.4.22.51	additional information	0.01% (v/v) of Triton X-100 does not interfere with enzyme activity	2	
3.4.22.51	additional information	not inhibited by CA-074-OMe	2	
3.4.22.51	additional information	the AS2 site as a target for the design of cruzain inhibitors is limited	2	
3.4.22.51	additional information	apolar substituents or halogen atom substitution at the aryl position improved cruzain inhibition and antiparasitic activity in comparison to unsubstituted thiosemicarbazone	2	
3.4.22.51	additional information	nitrile-based inhibitors are efficient inhibitors of cruzain that bind by forming a covalent bond with this enzyme	2