2.8.1.6	5'-deoxyadenosine	strong inhibitor, reversible, 90% inhibition upon addition of 1 equivalent of 5'-deoxyadenosine with regard to the enzyme	943	
2.8.1.6	5'-deoxyadenosine	product inhibition. The combination of both products in equimolar concentrations results in more than simple additive inhibition, suggesting that they bind cooperatively to the enzyme.	943	
2.8.1.6	5'-deoxyadenosine	competitive, inhibits the growth of Mycobacterium tuberculosis H37Ra with an MIC of 392.6 microg/ml	943	
2.8.1.6	acidomycin	structural analog of biotin, complete inhibition at 0.4 mM, 50% inhibition at 0.035 mM	115159	
2.8.1.6	acidomycin	acidomycin inhibits biotin synthesis through the competitive inhibition of biotin synthase BioB and also stimulates unproductive cleavage of S-adenosyl-L-methionine to generate the toxic metabolite 5'-deoxyadenosine. Acidomycin selectively accumulates in Mycobycterium tuberculosis. The development of spontaneous resistance by Mycobacterium tuberculosis to acidomycin is difficult, and only low-level resistance to acidomycin is observed by overexpression of BioB	115159	
2.8.1.6	Cd2+	1 mM, almost complete inhibition	52	
2.8.1.6	Co2+	1 mM, almost complete inhibition	23	
2.8.1.6	Cu2+	1 mM, almost complete inhibition	19	
2.8.1.6	Fe2+	above 1 mM	25	
2.8.1.6	Hg2+	1 mM, almost complete inhibition	33