2.7.11.10 (1R,4R)-4-(2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-cyclohexanol - 254288 2.7.11.10 (4-([4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino)phenyl)acetic acid IC50 for the IKKbeta is 0.0022 mM 57755 2.7.11.10 (E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol the compound directly binds to the ATP binding site of the enzyme with a strong binding affinity 256714 2.7.11.10 (E)-4-[3-(5-(adamant-1-yl)-2-(but-1-oxy)-4-(2-methoxyethoxymethoxy)-phenyl)-3-oxoprop-1-en-1-yl]benzoic acid shows highest inhibition of IKKbeta and highest induction of apoptosis in Jurkat cells 146817 2.7.11.10 (E)-4-[3-(5-(adamant-1-yl)-2-(hexyl-1-oxy)-4-(2-methoxyethoxymethoxy)phenyl)-3-oxoprop-1-en-1-yl]benzoic acid exhibits improved anti-IKKbeta and growth inhibitory activities and has lost its RAR-dependent transactivation function 146819 2.7.11.10 (E)-4-[3-(5-(adamant-1-yl)-2-ethoxy-4-(2-methoxyethoxymethoxy)phenyl)-3-oxoprop-1-en-1-yl]benzoic acid - 146821 2.7.11.10 (E)-4-[3-(5-(adamant-1-yl)-4-(2-methoxyethoxymethoxy)-2-(pentyl-1-oxy)phenyl)-3-oxoprop-1-en-1-yl]benzoic acid - 146823 2.7.11.10 (E)-4-[3-(5-(adamant-1-yl)-4-(2-methoxyethoxymethoxy)-2-(prop-2-en-1-oxy)phenyl)-3-oxoprop-1-en-1-yl]benzoic acid - 146824 2.7.11.10 (E)-4-[3-(5-(adamant-1-yl)-4-(2-methoxyethoxymethoxy)-2-(prop-2-yn-1-oxy)phenyl)-3-oxoprop-1-en-1-yl]benzoic acid shows highest inhibition of IKKbeta and highest induction of apoptosis in Jurkat cells 146818 2.7.11.10 (E)-4-[3-(5-(adamant-1-yl)-4-(2-methoxyethoxymethoxy)-2-phenylmethoxy-phenyl)-3-oxoprop-1-en-1-yl]benzoic acid exhibits improved anti-IKKbeta and growth inhibitory activities and has lost its RAR-dependent transactivation function 146820