7.6.2.1 1-monoolein 0.5 mM significantly reduce the P-glycoprotein protein expression, 0.1 mM of 1-monoolein does not have any significant effect on the expression of P-glycoprotein 19869 7.6.2.1 1-monostearin 0.5 mM significantly reduce the P-glycoprotein protein expression, 0.1 mM of 1-monostearin does not have any significant effect on the expression of P-glycoprotein 31725 7.6.2.1 4-(2-aminoethyl)benzenesulfonyl fluoride flippase activity for 1-oleoyl-2-[6-(7-nitrol-2-1,3-benzonadiol-4-yl)amino]-sn-glycerophosphoethanolamine is inhibited by 72% at 5 mM 4-(2-aminoethyl)benzenesulfonyl fluoride, flippase activity for 1-oleoyl-2-[6-(7-nitrol-2-1,3-benzonadiol-4-yl)amino]-sn-glycerophosphocholine is inhibited by 75% at 5 mM 4-(2-aminoethyl)benzenesulfonyl fluoride 4308 7.6.2.1 4-hydroxy-2-nonenal - 1426 7.6.2.1 5,5'-dithiobis(2-nitrobenzoic acid) flippase activity for 1-oleoyl-2-[6-(7-nitrol-2-1,3-benzonadiol-4-yl)amino]-sn-glycerophosphoethanolamine is inhibited by 80% at 20 mM 5,5'-dithiobis(2-nitrobenzoic acid), flippase activity for 1-oleoyl-2-[6-(7-nitrol-2-1,3-benzonadiol-4-yl)amino]-sn-glycerophosphocholine is inhibited by 60% at 20 mM 5,5'-dithiobis(2-nitrobenzoic acid) 221 7.6.2.1 acrolein - 1198 7.6.2.1 AlFx trapping of MsbA with 0.8 mM AlFx results in incomplete inhibition of activity 169879 7.6.2.1 AMP-PNP - 4099 7.6.2.1 azide - 230 7.6.2.1 Bcl-2 PLS3 and tBid may form a bidirectional positive feedback loop that is antagonized by Bcl-2 17958 7.6.2.1 BeFx trapping of MsbA with 0.8 mM BeFx results in incomplete inhibition of activity 48846 7.6.2.1 Ca2+ 0.0002 mM, inhibits from the cytofacial surface 15 7.6.2.1 Ca2+ - 15 7.6.2.1 Cd2+ - 52 7.6.2.1 cholesterol the transport activity of P-glycoprotein decreases by about 20% cholesterol 189 7.6.2.1 cyclosporin A inhibition of phospholipid flipping 1044 7.6.2.1 Diamide - 2482 7.6.2.1 diethyldicarbonate rat liver contains two populations, DEPC-sensitive and DEPC-insensitive, of flippases, which can be in a different of DEPC sensitivity or be two different proteins 310 7.6.2.1 DTNB - 554 7.6.2.1 EDTA - 21 7.6.2.1 elaiophylin partial inhibition of Mg+-ATPase activity, translocation of phosphatidylserine is almost completely abolished 105995 7.6.2.1 eosin Y almost complete inhibition of both Mg2+-ATPase activity and translocation 13174 7.6.2.1 F- inhibition increases in the presence of 0.01 mM AlCl3 174 7.6.2.1 F- NaF 174 7.6.2.1 Kes1p Kes1p represses the flippase activity of Drs2p in trans-Golgi network membranes 151900 7.6.2.1 La3+ - 1928 7.6.2.1 lipid A lipid A inhibits translocation by approx. 30% at 0.01-0.04 mg/ml 9205 7.6.2.1 methyl-beta-cyclodextrin transport of 0.001 mM tetramethylrosamine is essentially abolished by 1 mM methyl-beta-cyclodextrin, and transport of 0.005 mM H33342 is almost completely inhibited by 5 mM methyl-beta-cyclodextrin 11065 7.6.2.1 additional information no inhibition by verapamil, no effect by ATP 2 7.6.2.1 additional information no inhibition by NEM 2 7.6.2.1 additional information no effect by ATP and NEM 2 7.6.2.1 additional information APLT is sensitive to redox modifications of its sulfhydryl groups, macrophages can directly participate in apoptotic cell clearance by S-nitrosylation/oxidation and inhibition of APLT causing PS externalization, reversible by DTT, overview, no inhibition and phagocytosis stimulation by S-nitrosoglutathione 2 7.6.2.1 additional information neither lipopolysaccharide from the Ra mutant of Escherichia coli nor deep rough chemotype lipopolysaccharide affect MsbA flippase activity significantly 2 7.6.2.1 additional information APLT ius inhibited after in vitro dehydration of normal and sickle erythrocytes 2 7.6.2.1 additional information no inhibition by ouabain and azide 2 7.6.2.1 additional information not inhibited by ouabain; not inhibited by ouabain; not inhibited by ouabain; not inhibited by ouabain; not inhibited by ouabain; not inhibited by ouabain; not inhibited by ouabain; not inhibited by ouabain; not inhibited by ouabain; not inhibited by ouabain 2 7.6.2.1 N-ethylmaleimide - 49 7.6.2.1 NaF - 235 7.6.2.1 NEM - 89 7.6.2.1 NEM rat liver contains two populations of, NEM-sensitive and NEM-insensitive, flippases, which can be in a different of NEM sensitivity or be two different proteins 89 7.6.2.1 NEM over 90% inhibition of ATPase activity at 1 mM 89 7.6.2.1 orthovanadate - 1328 7.6.2.1 phosphate analogue Vi the presence of 0.1-0.2 m M Vi inhibits flippase activity of MsbA by approx. 50% 169878 7.6.2.1 pyridyldithioethylamine - 107152 7.6.2.1 ribavirin prolonged treatment of erythrocytes with ribavirin results in surface exposure of phosphatidylserine, mainly caused by inactivation of the aminophospholipid translocase. Inactivation is due to severe ATP depletion 1304 7.6.2.1 S-nitroso-L-cysteine-ethyl ester i.e. SNCEE, causes intracellular and extracellular trans-nitrosylation of proteins, respectively. Nitrosative stress inhibits the enzyme, and SNCEE causes significant S-nitrosylation/oxidation of thiols in HL-60 cells. SNCEE also strongly inhibites APLT, activated scramblase, and causes PS externalization, reversible by DTT 144086 7.6.2.1 sulfhydryl reagents - 978 7.6.2.1 suramin competitive inhibitor of ATP towards both Mg2+-ATPase activity and aminophospholipid translocation. Inhibition of translocation occurs at higher inhibitor concentration than the inhibition of Mg2+-ATPase activity 704 7.6.2.1 Trypsin - 393 7.6.2.1 vanadate biphasic inhibition 233 7.6.2.1 vanadate - 233 7.6.2.1 vanadate inhibits the enzyme from the cytofacial surface 233 7.6.2.1 vanadate 75% inhibition of ATP hydrolysis at 0.1 mM vanadate 233 7.6.2.1 vanadate maximal half-inhibition at 0.035 mM 233 7.6.2.1 vanadate over 90% inhibition of ATPase activity at 0.1 mM 233 7.6.2.1 vanadyl ion inhibits the enzyme from the extracellular surface 107472 7.6.2.1 verapamil inhibition of phospholipid flipping 1389 7.6.2.1 verapamil complete inhibition at 0.05 mM 1389 7.6.2.1 vinblastine inhibition of phospholipid flipping 3132