6.5.1.2 additional information not inhibited by trimethoprim 2 6.5.1.2 additional information not inhibited by cinchonidine, quinine, and N,N'-bis[4chloroquinolin-8-yl]succinamide 2 6.5.1.2 ATP inhibits adenylation reaction 4 6.5.1.2 ATP 1 mM 4 6.5.1.2 NAD+ inhibitory above 0.1 mM, activity is abolished at 0.5 mM 7 6.5.1.2 Mn2+ activation at 0.2-1.0 mM, inhibition at higher concentration 11 6.5.1.2 ADP inhibits adenylation reaction 13 6.5.1.2 AMP inhibits adenylation reaction 30 6.5.1.2 AMP - 30 6.5.1.2 Na+ above 20-150 mM 59 6.5.1.2 KCl inhibition by KCl occurs at greater than 30 mM (NH4)2SO 79 6.5.1.2 putrescine - 155 6.5.1.2 methotrexate IC50 of 0.008 mg/ml 241 6.5.1.2 cAMP inhibits adenylation reaction 268 6.5.1.2 (NH4)2SO4 (NH4)2SO4 concentrations higher than 30 mM are inhibitory. At 100 mM KCl, concentrations of (NH4)2SO4 above 12 mM are inhibitory 399 6.5.1.2 doxorubicin IC50: 0.0033 mM 832 6.5.1.2 doxorubicin doxorubicin inhibits the ATP-dependent DNA ligase of bacteriophage T4 and the Escherichia coli NAD+-dependent ligase with a similar potency 832 6.5.1.2 Chloroquine effective inhibitor 1439 6.5.1.2 Chloroquine - 1439 6.5.1.2 Quinacrine powerful inhibitor, exhibits good inhibition at nanomolar concentrations 1593 6.5.1.2 Quinacrine - 1593 6.5.1.2 nicotinamide mononucleotide - 1831 6.5.1.2 adriamycin - 2134 6.5.1.2 1,N6-etheno-NAD+ - 5453 6.5.1.2 2-(butylsulfanyl)adenosine - 7919 6.5.1.2 2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine - 7920 6.5.1.2 2-(cyclopentyloxy)-5'-deoxyadenosine - 7921 6.5.1.2 5'-deoxy-5'-fluoro-2-[(trans-4-methylcyclohexyl)oxy]adenosine - 7922 6.5.1.2 5'-deoxy-2-(spiro[2.2]pent-1-ylmethoxy)adenosine - 7923 6.5.1.2 12-(6-piperidin-1-ylhexyl)-7,12-dihydro-6H-[1]benzothiepino[5,4-b]indole - 18319 6.5.1.2 Chloroquinone - 29853 6.5.1.2 2-methylthio-ATP - 36466 6.5.1.2 2-methylthio-ATP potent inhibitor 36466 6.5.1.2 hydroxychloroquine specific inhibitor of the Escherichia coli enzyme 38397 6.5.1.2 hydroxychloroquine - 38397 6.5.1.2 Chloroquine diphosphate IC50: 0.0014 mM 43920 6.5.1.2 (8R,10R)-10-((4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-6,8,11-trihydroxy-8-hydroxymethoxymethyl-1-methoxy-7,8,9,10-tetrahydro-naphthacene-5,12-dione IC50: 0.005 mM 52953 6.5.1.2 3-((R)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-3-[3-(3-{3-[1-((S)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-2-ethoxycarbonyl-ethyl]-ureido}-phenyl)-ureido]-propionic acid ethyl ester IC50: 0.0277 mM 53898 6.5.1.2 3-((R)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-3-(3-phenoxymethyl-thioureido)-propionic acid ethyl ester IC50: 0.004 mM 53899 6.5.1.2 N1-(7-chloro-[4]quinolyl)-N4,N4-bis-(2-hydroxy-ethyl)-1-methyl-butanediyldiamine IC50: 0.046 mM 57554 6.5.1.2 5-[[[(4-chlorophenyl)amino]carbonyl](phenylmethyl)amino]-5,6-dideoxy-1,2-O-(1-methylethylidene)-3-O-(phenylmethyl)-alpha-L-gluco-heptofuranuronic acid ethyl ester IC50: 0.00965 mM 57910 6.5.1.2 pyridochromanone IC50: 0.0006 mM 57911 6.5.1.2 2-methylthio ADP - 63036 6.5.1.2 N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentame-1,4-diamine - 66870 6.5.1.2 N,N'-bis[4-((4-(diethylamino)-1-methylbutyl)amino)-quinoline-6-yl]sebacamide powerful inhibitor, exhibits good inhibition at nanomolar concentrations 72035 6.5.1.2 N,N'-bis[4-((4-(diethylamino)-1-methylbutyl)amino)-quinoline-8-yl]adipamide powerful inhibitor, exhibits good inhibition at nanomolar concentrations 72036 6.5.1.2 2,4-diamino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carbonitrile powerful inhibitor, exhibits good inhibition at nanomolar concentrations 72037 6.5.1.2 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide powerful inhibitor, exhibits good inhibition at nanomolar concentrations 72038 6.5.1.2 2-amino-7-fluoro-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide powerful inhibitor, exhibits good inhibition at nanomolar concentrations, better inhibitor than 2-amino-7,8-difluoro-5-oxo-4a,10a-dihydro-5H-chromeno[2,3-b]pyridine-3-carboxamide 72039 6.5.1.2 2-amino-7,8-difluoro-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide powerful inhibitor, exhibits good inhibition at nanomolar concentrations, worse inhibitor than 2-amino-7-fluoro-5-oxo-4a,10a-dihydro-5H-chromeno[2,3-b]pyridine-3-carboxamide 72040 6.5.1.2 3,3'-(propane-1,3-diylbis(azanediyl))bis(3-(6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[2,3-d][1,3]dioxol-5-yl)propan-1-ol) - 72041 6.5.1.2 3,3'-(decane-1,10-diylbis(azanediyl))bis(3-(6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)propan-1-ol) - 72042 6.5.1.2 N,N'-bis[[(3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]methyl]dodecane-1,12-diamine - 72043 6.5.1.2 (29S,34S,36R,37R)-1,1'-(1,3-phenylene)bis(3-((S)-1-((3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)-3-hydroxypropyl)urea) - 72044 6.5.1.2 (29S,34S,36R,37R)-1,1'-(1,4-phenylene)bis(3-((S)-1-((3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)-3-ethoxy-3-oxopropyl)urea) - 72045 6.5.1.2 ethyl-3-O-benzyl-5,6-dideoxy-1,2-O-(1-methylethylidene)-5-[[(phenylcarbonyl)carbamoyl]amino]-alpha-L-xylo-heptofuranuronate - 72046 6.5.1.2 ethyl-3-O-benzyl-5-[benzyl[(4-chlorophenyl)carbamoyl]amino]-5,6-dideoxy-1,2-O-(1-methylethylidene)-alpha-L-xylo-heptofuranuronate - 72047 6.5.1.2 N4-(7-chloro-7,8-dihydroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine - 72048 6.5.1.2 ethyl 3-(1-benzyl-3-(4-chlorophenyl)ureido)-3-(6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)propanoate - 72049 6.5.1.2 ethyl 3-(3-benzoylthioureido)-3-(6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)propanoate - 72050 6.5.1.2 (3S,3'R)-3,3'-(propane-1,3-diyldiimino)bis[3-[(3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]propan-1-ol] - 72051 6.5.1.2 2,4-diamino-7-dimethylamino-pyrimido[4,5-d]pyrimidine IC50 of 0.0001 mg/ml, specific inhibitor of NAD+-dependent DNA ligase, inhibits competitively with respect to NAD+ and specifically inhibits enzyme adenylation, but not DNA adenylation or ligation 72052 6.5.1.2 pyridochromanones differently substituted compounds tested and all found to be inhibitory, competitive with NAD+, inhibitory in nano-molar rage without affecting human DNA-ligase (ATP-depentend) activity 118767 6.5.1.2 Sp-cAMPS - 135725 6.5.1.2 Rp-cAMPS - 135726 6.5.1.2 mitonafide i.e. 3-nitro-N-(2-(dimethylamino)ethyl)-1,8-naphthalimide 147502 6.5.1.2 2-amino-5H-chromeno[2,3-b]pyridine-3-carboxamide powerful inhibitor, exhibits good inhibition at nanomolar concentrations 147593 6.5.1.2 N-[6-piperidin-1-ylhexyl]-6,7-dihydrobenzo[b]indolo[2,3-d]thiepine LX competes with NAD+ andf inhibits the enzyme with IC50 in the low micromolar range, LX exhibits around 15fold better inhibition of the Mycobacterium tuberculosis enzyme compared to the human DNA ligase 147594 6.5.1.2 3-amino-6-[(6-chloro-2-methoxyacridin-9-yl)amino]heptan-1-ol - 165568 6.5.1.2 N'-(6-chloro-2-methoxyacridin-9-yl)-N,N-dimethylbutane-1,4-diamine - 165569 6.5.1.2 N'-(6-chloro-2-methoxyacridin-9-yl)-N,N-diethylbutane-1,4-diamine - 165570 6.5.1.2 (4R)-N4-(6-chloro-2-methoxyacridin-9-yl)-N1,N1-diethylpentane-1,4-diamine - 165571 6.5.1.2 N-(6-chloro-2-methoxyacridin-9-yl)butane-1,4-diamine - 165572 6.5.1.2 N-(4-aminobutyl)-N-(3-aminopropyl)-N'-(6-chloro-2-methoxyacridin-9-yl)butane-1,4-diamine - 165573 6.5.1.2 N,N-bis(4-aminobutyl)-N'-(6-chloro-2-methoxyacridin-9-yl)butane-1,4-diamine - 165574 6.5.1.2 N-(4-aminobutyl)-N-(3-aminopropyl)-N'-(6-chloro-2-methoxyacridin-9-yl)pentane-1,5-diamine - 165575 6.5.1.2 N,N-bis(4-aminobutyl)-N'-(6-chloro-2-methoxyacridin-9-yl)pentane-1,5-diamine - 165576 6.5.1.2 N-(4-aminobutyl)-N-[3-[(6-chloro-2-methoxyacridin-9-yl)amino]propyl]butane-1,4-diamine - 165577 6.5.1.2 6-chloro-2-methoxy-N-[4-(piperidin-1-yl)pentyl]acridin-9-amine - 165578 6.5.1.2 3-chloro-N9-[5-(diethylamino)pentan-2-yl]-7-methoxyacridine-2,9-diamine - 165579 6.5.1.2 3-chloro-9-[[5-(diethylammonio)pentan-2-yl]amino]-7-methoxyacridin-2-aminium - 165580 6.5.1.2 2,2'-([4-[(6-chloro-2-methoxyacridin-9-yl)amino]pentyl]imino)diethanol - 165581 6.5.1.2 N1,N1-bis(2-chloroethyl)-N4-(6-chloro-2-methoxyacridin-9-yl)pentane-1,4-diamine - 165582 6.5.1.2 6-chloro-9-[[5-(diethylammonio)pentan-2-yl]amino]-2-methoxyacridinium - 165583 6.5.1.2 2-amino-7-[2-(benzyloxy)propan-2-yl]-6-bromo-1,8-naphthyridine-3-carboxamide - 193880 6.5.1.2 2-amino-6-bromo-5-[(2-hydroxyethyl)(methyl)amino]-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193881 6.5.1.2 2-amino-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193882 6.5.1.2 2-amino-5-methyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193883 6.5.1.2 2-amino-5-(2-methoxyethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193884 6.5.1.2 2-amino-5-(2-hydroxyethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193885 6.5.1.2 2-amino-5-(aminomethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193886 6.5.1.2 2-amino-5-phenyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193887 6.5.1.2 2-amino-6-chloro-5-ethyl-1,8-naphthyridine-3-carboxamide - 193888 6.5.1.2 2-amino-6-benzyl-7-chloro-5-methyl-1,8-naphthyridine-3-carboxamide - 193889 6.5.1.2 2-amino-7-chloro-5-methyl-6-(prop-2-en-1-yl)-1,8-naphthyridine-3-carboxamide - 193890 6.5.1.2 2-amino-7-chloro-5-methyl-6-(pyridin-4-ylmethyl)-1,8-naphthyridine-3-carboxamide - 193891 6.5.1.2 2-amino-6-bromo-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193892 6.5.1.2 7-methoxy-6-methylpteridine-2,4-diamine - 193893 6.5.1.2 2-amino-6-bromo-7-cyclopentyl-1,8-naphthyridine-3-carboxamide - 193894 6.5.1.2 4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide - 193895 6.5.1.2 tert-butyl 3-(7-amino-3-bromo-6-carbamoyl-1,8-naphthyridin-2-yl)azetidine-1-carboxylate - 193896 6.5.1.2 2-amino-6-methyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193897 6.5.1.2 2-amino-6-ethenyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193898 6.5.1.2 2-amino-6-ethyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193899 6.5.1.2 2-amino-6-(propan-2-yl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193900 6.5.1.2 2-amino-6-cyclopropyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193901 6.5.1.2 2-amino-6-cyclopentyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193902 6.5.1.2 2-amino-6-benzyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193903 6.5.1.2 2-amino-6-(2-phenylethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193904 6.5.1.2 2-amino-6-(hydroxymethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193905 6.5.1.2 2-amino-6-bromo-5-(3-hydroxyazetidin-1-yl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193906 6.5.1.2 2-amino-6-bromo-5-[(3R)-3-hydroxypyrrolidin-1-yl]-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193907 6.5.1.2 4-amino-2-(cyclopentylsulfanyl)-8-[(1R)-2-hydroxycyclopentyl]pyrido[2,3-d]pyrimidin-5(8H)-one - 193908 6.5.1.2 2-amino-6-bromo-7-tert-butyl-1,8-naphthyridine-3-carboxamide - 193909 6.5.1.2 (2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol - 193910 6.5.1.2 2-(pentylsulfanyl)adenosine - 193912 6.5.1.2 2-(pentyloxy)adenosine - 193913 6.5.1.2 5'-deoxy-5'-fluoro-2-(pentyloxy)adenosine - 193914 6.5.1.2 5'-deoxy-2-(pentyloxy)adenosine - 193915 6.5.1.2 5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine - 193916 6.5.1.2 5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine - 193917 6.5.1.2 5'-deoxy-2-phenoxyadenosine - 193918 6.5.1.2 9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine - 193919 6.5.1.2 2-(cyclopentyloxy)-9-[3,5-dideoxy-5-fluoro-3-(2l5-triaz-1-en-2-yn-1-yl)-b-D-xylofuranosyl]-9H-purin-6-amine - 193920 6.5.1.2 9-(3-chloro-3-deoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine - 193921 6.5.1.2 2-(cyclopentyloxy)-5'-deoxy-3'-O-(3,4-dichlorobenzyl)adenosine - 193922 6.5.1.2 4-amino-6-(1H-benzimidazol-2-yl)pyridazin-3(2H)-one - 193923 6.5.1.2 4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide - 193924 6.5.1.2 2-amino-5-[(3R)-3-aminopyrrolidin-1-yl]-6-bromo-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193925 6.5.1.2 4-aminothieno[3,2-c]pyridine-7-carboxamide - 193926 6.5.1.2 4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide - 193927 6.5.1.2 4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide - 193928 6.5.1.2 ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate - 193929 6.5.1.2 4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide - 193930 6.5.1.2 4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide - 193931 6.5.1.2 4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide - 193932 6.5.1.2 4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide - 193933 6.5.1.2 4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide - 193934 6.5.1.2 4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide - 193935 6.5.1.2 2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide - 193936 6.5.1.2 2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide - 193937 6.5.1.2 2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide - 193938 6.5.1.2 9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(spiro[2.2]pent-1-ylmethoxy)-9H-purin-6-amine - 193939 6.5.1.2 2-amino-6-bromo-5-(4-hydroxypiperidin-1-yl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193941 6.5.1.2 4-amino-2-(1,4-dioxaspiro[4.5]dec-8-yloxy)-8-[(1R)-2-hydroxycyclopentyl]pyrido[2,3-d]pyrimidin-5(8H)-one - 193985 6.5.1.2 2-(butylsulfanyl)-5'-deoxyadenosine - 194028 6.5.1.2 2-(cyclopentyloxy)adenosine - 194057 6.5.1.2 4-amino-2-[(2-methylcyclohexyl)oxy]-8-(1H-pyrazol-4-ylmethyl)pyrido[2,3-d]pyrimidin-5(8H)-one - 194060 6.5.1.2 4-amino-2-(2-fluoroethoxy)-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one - 194062 6.5.1.2 4-amino-8-(2-hydroxyethyl)-2-(propan-2-yloxy)pyrido[2,3-d]pyrimidin-5(8H)-one - 194063 6.5.1.2 4-amino-2-[(1,3-difluoropropan-2-yl)oxy]-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one - 194064 6.5.1.2 4-amino-8-(2-hydroxyethyl)-2-(4-methylcyclohexyl)pyrido[2,3-d]pyrimidin-5(8H)-one - 194065 6.5.1.2 4-amino-8-(2-hydroxyethyl)-2-(2-methylcyclohexyl)pyrido[2,3-d]pyrimidin-5(8H)-one - 194066 6.5.1.2 4-amino-8-(2,3-dihydroxypropyl)-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194067 6.5.1.2 4-amino-8-(3-fluoro-2-hydroxypropyl)-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194068 6.5.1.2 4-amino-2-[(2-methylcyclohexyl)oxy]-8-[(1R,5R)-7-oxo-6-oxabicyclo[3.2.1]oct-4-yl]pyrido[2,3-d]pyrimidin-5(8H)-one - 194071 6.5.1.2 4-([4-amino-2-[(2-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl]methyl)benzoic acid - 194072 6.5.1.2 4-amino-2-(cyclopentylsulfanyl)-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one - 194073 6.5.1.2 4-amino-8-[(3,4-dihydroxycyclopentyl)methyl]-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194074 6.5.1.2 4-amino-2-(cyclopentyloxy)-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one - 194075 6.5.1.2 4-amino-8-[[(2R)-2-hydroxycyclopentyl]methyl]-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194076 6.5.1.2 4-amino-8-[[(4S)-4-hydroxytetrahydrofuran-3-yl]methyl]-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194077 6.5.1.2 4-amino-8-[(2R)-2-hydroxycyclohexyl]-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194078 6.5.1.2 4-amino-8-[(2R)-2-hydroxycyclopentyl]-2-[(4-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194079 6.5.1.2 4-amino-8-[(1S,2S)-2-hydroxycyclopentyl]-2-[(4-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194080 6.5.1.2 4-amino-8-[(2S,5S)-2,5-dihydroxycyclopentyl]-2-[(4-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194081 6.5.1.2 4-amino-8-[(1S)-2,3-dihydroxycyclopentyl]-2-[(4-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194082 6.5.1.2 (3S)-3-[4-amino-2-[(4-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl]-4-hydroxycyclopentanecarboxamide - 194083 6.5.1.2 (3S)-3-[4-amino-2-[(4-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl]-4-hydroxycyclopentanecarboxylic acid - 194084 6.5.1.2 5-([4-amino-2-[(4-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl]methyl)thiophene-2-carboxylic acid - 194085 6.5.1.2 4-amino-2-[(2,4-dimethylcyclohexyl)oxy]-8-[(1R)-2-hydroxycyclopentyl]pyrido[2,3-d]pyrimidin-5(8H)-one - 194086 6.5.1.2 4-amino-8-[(1R)-2-hydroxycyclopentyl]-2-[[4-(trifluoromethyl)cyclohexyl]oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194087 6.5.1.2 4-amino-2-[(4-chlorocyclohexyl)oxy]-8-[(1R)-2-hydroxycyclopentyl]pyrido[2,3-d]pyrimidin-5(8H)-one - 194088 6.5.1.2 4-amino-8-(cyclopent-3-en-1-ylmethyl)-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194089 6.5.1.2 4-amino-2-(cyclopentylamino)-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one - 194103 6.5.1.2 (2R,3R,4S,5R)-2-[6-amino-2-(butylsulfanyl)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol - 194638 6.5.1.2 deoxyribonucleotide - 194639 6.5.1.2 (4-amino-2-[(2-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)acetonitrile - 194640 6.5.1.2 3-(4-amino-2-[(2-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)propanenitrile - 194641 6.5.1.2 (2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate - 226308 6.5.1.2 (3aR,5R,6R,6aS)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-6-hydroxy-2-sulfanyltetrahydro-2H-2lambda5-furo[2,3-d][1,3,2]dioxaphosphol-2-one - 226335 6.5.1.2 1,6-bis(3,4-dimethoxyphenyl)dispiro[2.1.2(5).2(3)]nonan-4-one - 226506 6.5.1.2 1,6-bis(3,4-dimethoxyphenyl)dispiro[2.1.2(5).3(3)]decan-4-one - 226507 6.5.1.2 1,6-bis(4-bromophenyl)dispiro[2.1.2(5).2(3)]nonan-4-one - 226508 6.5.1.2 1,6-bis(4-fluorophenyl)dispiro[2.1.2(5).2(3)]nonan-4-one - 226509 6.5.1.2 1,6-bis(4-methoxyphenyl)dispiro[2.1.2(5).2(3)]nonan-4-one - 226510 6.5.1.2 1,6-bis(4-methoxyphenyl)dispiro[2.1.2(5).3(3)]decan-4-one - 226511 6.5.1.2 2,4-diamino-7-tert-butyl-1,8-naphthyridine-3-carbonitrile - 226601 6.5.1.2 2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile - 226602 6.5.1.2 2,7-bis[(3,4,5-trimethoxyphenyl)methyl]cycloheptan-1-one - 226609 6.5.1.2 2-(butylsulfanyl)-5-hydroadenosine - 226684 6.5.1.2 2-(cyclopentyloxy)-3',5'-dideoxy-3'-[(3,5-dichlorophenyl)methyl]adenosine - 226687 6.5.1.2 2-(cyclopentyloxy)-3',5'-dideoxy-5'-fluoro-3'-(1H-triaziren-1-yl)adenosine - 226688 6.5.1.2 2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine - 226689 6.5.1.2 2-(cyclopentylsulfanyl)adenosine - 226690 6.5.1.2 2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide - 226714 6.5.1.2 2-amino-6,7-dimethoxyquinoline-3-carboxamide - 226715 6.5.1.2 2-amino[1,4]benzodioxino[2,3-b]pyridine-3-carboxamide - 226717 6.5.1.2 2-[(bicyclo[3.1.0]hexan-3-yl)oxy]-5'-deoxyadenosine - 226765 6.5.1.2 2-[(decahydronaphthalen-2-yl)oxy]-5'-deoxyadenosine - 226766 6.5.1.2 2-[(decahydronaphthalen-2-yl)oxy]adenosine - 226767 6.5.1.2 3'-chloro-2-(cyclopentyloxy)-3',5'-dideoxyadenosine - 226799 6.5.1.2 3'-chloro-2-(cyclopentyloxy)-3'-deoxyadenosine - 226800 6.5.1.2 3'-chloro-3',5'-dideoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine - 226801 6.5.1.2 3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium - 226905 6.5.1.2 3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium - 226906 6.5.1.2 5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine - 227018 6.5.1.2 5'-deoxy-2-[(tricyclo[3.3.1.1~3,7~]decan-2-yl)methoxy]adenosine - 227019 6.5.1.2 5'-deoxy-5'-fluoro-2-[(1,3-thiazol-2-yl)methoxy]adenosine - 227020 6.5.1.2 5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227032 6.5.1.2 5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227033 6.5.1.2 5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227034 6.5.1.2 5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227035 6.5.1.2 5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227036 6.5.1.2 5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227037 6.5.1.2 5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227038 6.5.1.2 5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227039 6.5.1.2 5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227040 6.5.1.2 5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227041 6.5.1.2 5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227042 6.5.1.2 5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227043 6.5.1.2 5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227044 6.5.1.2 5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227045 6.5.1.2 5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227046 6.5.1.2 5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227047 6.5.1.2 5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227048 6.5.1.2 5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227049 6.5.1.2 5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227050 6.5.1.2 5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227051 6.5.1.2 5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227052 6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227053 6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227054 6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227055 6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227056 6.5.1.2 5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227057 6.5.1.2 5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227058 6.5.1.2 5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227059 6.5.1.2 5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227060 6.5.1.2 5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227061 6.5.1.2 5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227062 6.5.1.2 5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227063 6.5.1.2 5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227064 6.5.1.2 5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227065 6.5.1.2 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227066 6.5.1.2 5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid - 227075 6.5.1.2 5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide - 227083 6.5.1.2 6-methyl-5-[(propan-2-yl)oxy][1,2,4]triazolo[1,5-a]pyrimidin-2-amine - 227180 6.5.1.2 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide - 227193 6.5.1.2 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide - 227194 6.5.1.2 8-hydroxy-2-methyl-3,4-dihydroquinoline-6-carboxamide - 227198 6.5.1.2 8-hydroxyquinoline-2-carboxylic acid - 227199 6.5.1.2 8-methoxy-2,3-dimethylquinoxalin-5-ol - 227200 6.5.1.2 ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate - 227232 6.5.1.2 ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate - 227233 6.5.1.2 (3aR,5R,6R,6aS)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-6-hydroxy-2-sulfanyltetrahydro-2H-2lambda-5-furo[2,3-d][1,3,2]dioxaphosphol-2-one - 227954 6.5.1.2 pinafide i.e. 3-nitro-N-(2-(1-pyrrolidinyl)ethyl)-1,8-naphthalimide 227955 6.5.1.2 chaetochromin - 227956 6.5.1.2 2-phenyl-NAD+ - 227957 6.5.1.2 2-iodo-AMP - 227958 6.5.1.2 2-iodo-NAD+ - 227959 6.5.1.2 (2R,3R,4S,5R)-2-[6-amino-2-(butylsulfanyl)-4,5-dihydro-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol - 227960 6.5.1.2 1-(4-aminopiperidin-1-yl)-6-(6,7-dihydro-12H-benzo[2,3]oxepino[4,5-b]indol-12-yl)-hexane-2-ol - 227961 6.5.1.2 1-(4-aminopiperidin-1-yl)-6-(dibenzo[b,e][1,4]oxazepin-5(11H)-yl)hexan-2-ol - 227962 6.5.1.2 6-(dibenzo[b,f][1,4]oxazepin-10(11H)-yl)-1-(piperidin-1-yl)hexan-2-ol - 227963