6.5.1.2 (29S,34S,36R,37R)-1,1'-(1,3-phenylene)bis(3-((S)-1-((3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)-3-hydroxypropyl)urea) - 72044 6.5.1.2 (29S,34S,36R,37R)-1,1'-(1,4-phenylene)bis(3-((S)-1-((3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)-3-ethoxy-3-oxopropyl)urea) - 72045 6.5.1.2 (2R,3R,4S,5R)-2-[6-amino-2-(butylsulfanyl)-4,5-dihydro-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol - 227960 6.5.1.2 (2R,3R,4S,5R)-2-[6-amino-2-(butylsulfanyl)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol - 194638 6.5.1.2 (2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol - 193910 6.5.1.2 (2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate - 226308 6.5.1.2 (3aR,5R,6R,6aS)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-6-hydroxy-2-sulfanyltetrahydro-2H-2lambda-5-furo[2,3-d][1,3,2]dioxaphosphol-2-one - 227954 6.5.1.2 (3aR,5R,6R,6aS)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-6-hydroxy-2-sulfanyltetrahydro-2H-2lambda5-furo[2,3-d][1,3,2]dioxaphosphol-2-one - 226335 6.5.1.2 (3S)-3-[4-amino-2-[(4-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl]-4-hydroxycyclopentanecarboxamide - 194083 6.5.1.2 (3S)-3-[4-amino-2-[(4-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl]-4-hydroxycyclopentanecarboxylic acid - 194084 6.5.1.2 (3S,3'R)-3,3'-(propane-1,3-diyldiimino)bis[3-[(3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]propan-1-ol] - 72051 6.5.1.2 (4-amino-2-[(2-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)acetonitrile - 194640 6.5.1.2 (4R)-N4-(6-chloro-2-methoxyacridin-9-yl)-N1,N1-diethylpentane-1,4-diamine - 165571 6.5.1.2 (8R,10R)-10-((4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-6,8,11-trihydroxy-8-hydroxymethoxymethyl-1-methoxy-7,8,9,10-tetrahydro-naphthacene-5,12-dione IC50: 0.005 mM 52953 6.5.1.2 (NH4)2SO4 (NH4)2SO4 concentrations higher than 30 mM are inhibitory. At 100 mM KCl, concentrations of (NH4)2SO4 above 12 mM are inhibitory 399 6.5.1.2 1,6-bis(3,4-dimethoxyphenyl)dispiro[2.1.2(5).2(3)]nonan-4-one - 226506 6.5.1.2 1,6-bis(3,4-dimethoxyphenyl)dispiro[2.1.2(5).3(3)]decan-4-one - 226507 6.5.1.2 1,6-bis(4-bromophenyl)dispiro[2.1.2(5).2(3)]nonan-4-one - 226508 6.5.1.2 1,6-bis(4-fluorophenyl)dispiro[2.1.2(5).2(3)]nonan-4-one - 226509 6.5.1.2 1,6-bis(4-methoxyphenyl)dispiro[2.1.2(5).2(3)]nonan-4-one - 226510 6.5.1.2 1,6-bis(4-methoxyphenyl)dispiro[2.1.2(5).3(3)]decan-4-one - 226511 6.5.1.2 1,N6-etheno-NAD+ - 5453 6.5.1.2 1-(4-aminopiperidin-1-yl)-6-(6,7-dihydro-12H-benzo[2,3]oxepino[4,5-b]indol-12-yl)-hexane-2-ol - 227961 6.5.1.2 1-(4-aminopiperidin-1-yl)-6-(dibenzo[b,e][1,4]oxazepin-5(11H)-yl)hexan-2-ol - 227962 6.5.1.2 12-(6-piperidin-1-ylhexyl)-7,12-dihydro-6H-[1]benzothiepino[5,4-b]indole - 18319 6.5.1.2 2,2'-([4-[(6-chloro-2-methoxyacridin-9-yl)amino]pentyl]imino)diethanol - 165581 6.5.1.2 2,4-diamino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carbonitrile powerful inhibitor, exhibits good inhibition at nanomolar concentrations 72037 6.5.1.2 2,4-diamino-7-dimethylamino-pyrimido[4,5-d]pyrimidine IC50 of 0.0001 mg/ml, specific inhibitor of NAD+-dependent DNA ligase, inhibits competitively with respect to NAD+ and specifically inhibits enzyme adenylation, but not DNA adenylation or ligation 72052 6.5.1.2 2,4-diamino-7-tert-butyl-1,8-naphthyridine-3-carbonitrile - 226601 6.5.1.2 2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile - 226602 6.5.1.2 2,7-bis[(3,4,5-trimethoxyphenyl)methyl]cycloheptan-1-one - 226609 6.5.1.2 2-(butylsulfanyl)-5'-deoxyadenosine - 194028 6.5.1.2 2-(butylsulfanyl)-5-hydroadenosine - 226684 6.5.1.2 2-(butylsulfanyl)adenosine - 7919 6.5.1.2 2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine - 7920 6.5.1.2 2-(cyclopentyloxy)-3',5'-dideoxy-3'-[(3,5-dichlorophenyl)methyl]adenosine - 226687 6.5.1.2 2-(cyclopentyloxy)-3',5'-dideoxy-5'-fluoro-3'-(1H-triaziren-1-yl)adenosine - 226688 6.5.1.2 2-(cyclopentyloxy)-5'-deoxy-3'-O-(3,4-dichlorobenzyl)adenosine - 193922 6.5.1.2 2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine - 226689 6.5.1.2 2-(cyclopentyloxy)-5'-deoxyadenosine - 7921 6.5.1.2 2-(cyclopentyloxy)-9-[3,5-dideoxy-5-fluoro-3-(2l5-triaz-1-en-2-yn-1-yl)-b-D-xylofuranosyl]-9H-purin-6-amine - 193920 6.5.1.2 2-(cyclopentyloxy)adenosine - 194057 6.5.1.2 2-(cyclopentylsulfanyl)adenosine - 226690 6.5.1.2 2-(pentyloxy)adenosine - 193913 6.5.1.2 2-(pentylsulfanyl)adenosine - 193912 6.5.1.2 2-amino-5-(2-hydroxyethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193885 6.5.1.2 2-amino-5-(2-methoxyethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193884 6.5.1.2 2-amino-5-(aminomethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193886 6.5.1.2 2-amino-5-methyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193883 6.5.1.2 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide powerful inhibitor, exhibits good inhibition at nanomolar concentrations 72038 6.5.1.2 2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide - 226714 6.5.1.2 2-amino-5-phenyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193887 6.5.1.2 2-amino-5-[(3R)-3-aminopyrrolidin-1-yl]-6-bromo-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193925 6.5.1.2 2-amino-5H-chromeno[2,3-b]pyridine-3-carboxamide powerful inhibitor, exhibits good inhibition at nanomolar concentrations 147593 6.5.1.2 2-amino-6,7-dimethoxyquinoline-3-carboxamide - 226715 6.5.1.2 2-amino-6-(2-phenylethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193904 6.5.1.2 2-amino-6-(hydroxymethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193905 6.5.1.2 2-amino-6-(propan-2-yl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193900 6.5.1.2 2-amino-6-benzyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193903 6.5.1.2 2-amino-6-benzyl-7-chloro-5-methyl-1,8-naphthyridine-3-carboxamide - 193889 6.5.1.2 2-amino-6-bromo-5-(3-hydroxyazetidin-1-yl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193906 6.5.1.2 2-amino-6-bromo-5-(4-hydroxypiperidin-1-yl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193941 6.5.1.2 2-amino-6-bromo-5-[(2-hydroxyethyl)(methyl)amino]-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193881 6.5.1.2 2-amino-6-bromo-5-[(3R)-3-hydroxypyrrolidin-1-yl]-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193907 6.5.1.2 2-amino-6-bromo-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193892 6.5.1.2 2-amino-6-bromo-7-cyclopentyl-1,8-naphthyridine-3-carboxamide - 193894 6.5.1.2 2-amino-6-bromo-7-tert-butyl-1,8-naphthyridine-3-carboxamide - 193909 6.5.1.2 2-amino-6-chloro-5-ethyl-1,8-naphthyridine-3-carboxamide - 193888 6.5.1.2 2-amino-6-cyclopentyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193902 6.5.1.2 2-amino-6-cyclopropyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193901 6.5.1.2 2-amino-6-ethenyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193898 6.5.1.2 2-amino-6-ethyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193899 6.5.1.2 2-amino-6-methyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193897 6.5.1.2 2-amino-7,8-difluoro-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide powerful inhibitor, exhibits good inhibition at nanomolar concentrations, worse inhibitor than 2-amino-7-fluoro-5-oxo-4a,10a-dihydro-5H-chromeno[2,3-b]pyridine-3-carboxamide 72040 6.5.1.2 2-amino-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide - 193882 6.5.1.2 2-amino-7-chloro-5-methyl-6-(prop-2-en-1-yl)-1,8-naphthyridine-3-carboxamide - 193890 6.5.1.2 2-amino-7-chloro-5-methyl-6-(pyridin-4-ylmethyl)-1,8-naphthyridine-3-carboxamide - 193891 6.5.1.2 2-amino-7-fluoro-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide powerful inhibitor, exhibits good inhibition at nanomolar concentrations, better inhibitor than 2-amino-7,8-difluoro-5-oxo-4a,10a-dihydro-5H-chromeno[2,3-b]pyridine-3-carboxamide 72039 6.5.1.2 2-amino-7-[2-(benzyloxy)propan-2-yl]-6-bromo-1,8-naphthyridine-3-carboxamide - 193880 6.5.1.2 2-amino[1,4]benzodioxino[2,3-b]pyridine-3-carboxamide - 226717 6.5.1.2 2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide - 193937 6.5.1.2 2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide - 193936 6.5.1.2 2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide - 193938 6.5.1.2 2-iodo-AMP - 227958 6.5.1.2 2-iodo-NAD+ - 227959 6.5.1.2 2-methylthio ADP - 63036 6.5.1.2 2-methylthio-ATP - 36466 6.5.1.2 2-methylthio-ATP potent inhibitor 36466 6.5.1.2 2-phenyl-NAD+ - 227957 6.5.1.2 2-[(bicyclo[3.1.0]hexan-3-yl)oxy]-5'-deoxyadenosine - 226765 6.5.1.2 2-[(decahydronaphthalen-2-yl)oxy]-5'-deoxyadenosine - 226766 6.5.1.2 2-[(decahydronaphthalen-2-yl)oxy]adenosine - 226767 6.5.1.2 3'-chloro-2-(cyclopentyloxy)-3',5'-dideoxyadenosine - 226799 6.5.1.2 3'-chloro-2-(cyclopentyloxy)-3'-deoxyadenosine - 226800 6.5.1.2 3'-chloro-3',5'-dideoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine - 226801 6.5.1.2 3,3'-(decane-1,10-diylbis(azanediyl))bis(3-(6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)propan-1-ol) - 72042 6.5.1.2 3,3'-(propane-1,3-diylbis(azanediyl))bis(3-(6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[2,3-d][1,3]dioxol-5-yl)propan-1-ol) - 72041 6.5.1.2 3-((R)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-3-(3-phenoxymethyl-thioureido)-propionic acid ethyl ester IC50: 0.004 mM 53899 6.5.1.2 3-((R)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-3-[3-(3-{3-[1-((S)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-2-ethoxycarbonyl-ethyl]-ureido}-phenyl)-ureido]-propionic acid ethyl ester IC50: 0.0277 mM 53898 6.5.1.2 3-(4-amino-2-[(2-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)propanenitrile - 194641 6.5.1.2 3-amino-6-[(6-chloro-2-methoxyacridin-9-yl)amino]heptan-1-ol - 165568 6.5.1.2 3-chloro-9-[[5-(diethylammonio)pentan-2-yl]amino]-7-methoxyacridin-2-aminium - 165580 6.5.1.2 3-chloro-N9-[5-(diethylamino)pentan-2-yl]-7-methoxyacridine-2,9-diamine - 165579 6.5.1.2 3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium - 226905 6.5.1.2 3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium - 226906 6.5.1.2 4-([4-amino-2-[(2-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl]methyl)benzoic acid - 194072 6.5.1.2 4-amino-2-(1,4-dioxaspiro[4.5]dec-8-yloxy)-8-[(1R)-2-hydroxycyclopentyl]pyrido[2,3-d]pyrimidin-5(8H)-one - 193985 6.5.1.2 4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide - 193931 6.5.1.2 4-amino-2-(2-fluoroethoxy)-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one - 194062 6.5.1.2 4-amino-2-(cyclopentylamino)-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one - 194103 6.5.1.2 4-amino-2-(cyclopentyloxy)-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one - 194075 6.5.1.2 4-amino-2-(cyclopentylsulfanyl)-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one - 194073 6.5.1.2 4-amino-2-(cyclopentylsulfanyl)-8-[(1R)-2-hydroxycyclopentyl]pyrido[2,3-d]pyrimidin-5(8H)-one - 193908 6.5.1.2 4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide - 193895 6.5.1.2 4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide - 193924 6.5.1.2 4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide - 193927 6.5.1.2 4-amino-2-[(1,3-difluoropropan-2-yl)oxy]-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one - 194064 6.5.1.2 4-amino-2-[(2,4-dimethylcyclohexyl)oxy]-8-[(1R)-2-hydroxycyclopentyl]pyrido[2,3-d]pyrimidin-5(8H)-one - 194086 6.5.1.2 4-amino-2-[(2-methylcyclohexyl)oxy]-8-(1H-pyrazol-4-ylmethyl)pyrido[2,3-d]pyrimidin-5(8H)-one - 194060 6.5.1.2 4-amino-2-[(2-methylcyclohexyl)oxy]-8-[(1R,5R)-7-oxo-6-oxabicyclo[3.2.1]oct-4-yl]pyrido[2,3-d]pyrimidin-5(8H)-one - 194071 6.5.1.2 4-amino-2-[(4-chlorocyclohexyl)oxy]-8-[(1R)-2-hydroxycyclopentyl]pyrido[2,3-d]pyrimidin-5(8H)-one - 194088 6.5.1.2 4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide - 193935 6.5.1.2 4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide - 193932 6.5.1.2 4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide - 193933 6.5.1.2 4-amino-6-(1H-benzimidazol-2-yl)pyridazin-3(2H)-one - 193923 6.5.1.2 4-amino-8-(2,3-dihydroxypropyl)-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194067 6.5.1.2 4-amino-8-(2-hydroxyethyl)-2-(2-methylcyclohexyl)pyrido[2,3-d]pyrimidin-5(8H)-one - 194066 6.5.1.2 4-amino-8-(2-hydroxyethyl)-2-(4-methylcyclohexyl)pyrido[2,3-d]pyrimidin-5(8H)-one - 194065 6.5.1.2 4-amino-8-(2-hydroxyethyl)-2-(propan-2-yloxy)pyrido[2,3-d]pyrimidin-5(8H)-one - 194063 6.5.1.2 4-amino-8-(3-fluoro-2-hydroxypropyl)-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194068 6.5.1.2 4-amino-8-(cyclopent-3-en-1-ylmethyl)-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194089 6.5.1.2 4-amino-8-[(1R)-2-hydroxycyclopentyl]-2-[[4-(trifluoromethyl)cyclohexyl]oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194087 6.5.1.2 4-amino-8-[(1S)-2,3-dihydroxycyclopentyl]-2-[(4-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194082 6.5.1.2 4-amino-8-[(1S,2S)-2-hydroxycyclopentyl]-2-[(4-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194080 6.5.1.2 4-amino-8-[(2R)-2-hydroxycyclohexyl]-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194078 6.5.1.2 4-amino-8-[(2R)-2-hydroxycyclopentyl]-2-[(4-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194079 6.5.1.2 4-amino-8-[(2S,5S)-2,5-dihydroxycyclopentyl]-2-[(4-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194081 6.5.1.2 4-amino-8-[(3,4-dihydroxycyclopentyl)methyl]-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194074 6.5.1.2 4-amino-8-[[(2R)-2-hydroxycyclopentyl]methyl]-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194076 6.5.1.2 4-amino-8-[[(4S)-4-hydroxytetrahydrofuran-3-yl]methyl]-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one - 194077 6.5.1.2 4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide - 193930 6.5.1.2 4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide - 193928 6.5.1.2 4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide - 193934 6.5.1.2 4-aminothieno[3,2-c]pyridine-7-carboxamide - 193926 6.5.1.2 5'-deoxy-2-(pentyloxy)adenosine - 193915 6.5.1.2 5'-deoxy-2-(spiro[2.2]pent-1-ylmethoxy)adenosine - 7923 6.5.1.2 5'-deoxy-2-phenoxyadenosine - 193918 6.5.1.2 5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine - 227018 6.5.1.2 5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine - 193916 6.5.1.2 5'-deoxy-2-[(tricyclo[3.3.1.1~3,7~]decan-2-yl)methoxy]adenosine - 227019 6.5.1.2 5'-deoxy-5'-fluoro-2-(pentyloxy)adenosine - 193914 6.5.1.2 5'-deoxy-5'-fluoro-2-[(1,3-thiazol-2-yl)methoxy]adenosine - 227020 6.5.1.2 5'-deoxy-5'-fluoro-2-[(trans-4-methylcyclohexyl)oxy]adenosine - 7922 6.5.1.2 5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine - 193917 6.5.1.2 5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227032 6.5.1.2 5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227033 6.5.1.2 5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227034 6.5.1.2 5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227035 6.5.1.2 5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227036 6.5.1.2 5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227037 6.5.1.2 5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227038 6.5.1.2 5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227039 6.5.1.2 5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227040 6.5.1.2 5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227041 6.5.1.2 5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227042 6.5.1.2 5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227043 6.5.1.2 5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227044 6.5.1.2 5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227045 6.5.1.2 5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227046 6.5.1.2 5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227047 6.5.1.2 5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227048 6.5.1.2 5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227049 6.5.1.2 5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227050 6.5.1.2 5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227051 6.5.1.2 5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227052 6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227053 6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227054 6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227055 6.5.1.2 5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227056 6.5.1.2 5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227057 6.5.1.2 5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227058 6.5.1.2 5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227059 6.5.1.2 5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227060 6.5.1.2 5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227061 6.5.1.2 5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227062 6.5.1.2 5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227063 6.5.1.2 5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227064 6.5.1.2 5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227065 6.5.1.2 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile - 227066 6.5.1.2 5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid - 227075 6.5.1.2 5-([4-amino-2-[(4-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl]methyl)thiophene-2-carboxylic acid - 194085 6.5.1.2 5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide - 227083 6.5.1.2 5-[[[(4-chlorophenyl)amino]carbonyl](phenylmethyl)amino]-5,6-dideoxy-1,2-O-(1-methylethylidene)-3-O-(phenylmethyl)-alpha-L-gluco-heptofuranuronic acid ethyl ester IC50: 0.00965 mM 57910 6.5.1.2 6-(dibenzo[b,f][1,4]oxazepin-10(11H)-yl)-1-(piperidin-1-yl)hexan-2-ol - 227963 6.5.1.2 6-chloro-2-methoxy-N-[4-(piperidin-1-yl)pentyl]acridin-9-amine - 165578 6.5.1.2 6-chloro-9-[[5-(diethylammonio)pentan-2-yl]amino]-2-methoxyacridinium - 165583 6.5.1.2 6-methyl-5-[(propan-2-yl)oxy][1,2,4]triazolo[1,5-a]pyrimidin-2-amine - 227180 6.5.1.2 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide - 227193 6.5.1.2 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide - 227194 6.5.1.2 7-methoxy-6-methylpteridine-2,4-diamine - 193893 6.5.1.2 8-hydroxy-2-methyl-3,4-dihydroquinoline-6-carboxamide - 227198 6.5.1.2 8-hydroxyquinoline-2-carboxylic acid - 227199 6.5.1.2 8-methoxy-2,3-dimethylquinoxalin-5-ol - 227200 6.5.1.2 9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine - 193919 6.5.1.2 9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(spiro[2.2]pent-1-ylmethoxy)-9H-purin-6-amine - 193939 6.5.1.2 9-(3-chloro-3-deoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine - 193921 6.5.1.2 ADP inhibits adenylation reaction 13 6.5.1.2 adriamycin - 2134 6.5.1.2 AMP inhibits adenylation reaction 30 6.5.1.2 AMP - 30 6.5.1.2 ATP inhibits adenylation reaction 4 6.5.1.2 ATP 1 mM 4 6.5.1.2 cAMP inhibits adenylation reaction 268 6.5.1.2 chaetochromin - 227956 6.5.1.2 Chloroquine effective inhibitor 1439 6.5.1.2 Chloroquine - 1439 6.5.1.2 Chloroquine diphosphate IC50: 0.0014 mM 43920 6.5.1.2 Chloroquinone - 29853 6.5.1.2 deoxyribonucleotide - 194639 6.5.1.2 doxorubicin IC50: 0.0033 mM 832 6.5.1.2 doxorubicin doxorubicin inhibits the ATP-dependent DNA ligase of bacteriophage T4 and the Escherichia coli NAD+-dependent ligase with a similar potency 832 6.5.1.2 ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate - 227232 6.5.1.2 ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate - 227233 6.5.1.2 ethyl 3-(1-benzyl-3-(4-chlorophenyl)ureido)-3-(6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)propanoate - 72049 6.5.1.2 ethyl 3-(3-benzoylthioureido)-3-(6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)propanoate - 72050 6.5.1.2 ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate - 193929 6.5.1.2 ethyl-3-O-benzyl-5,6-dideoxy-1,2-O-(1-methylethylidene)-5-[[(phenylcarbonyl)carbamoyl]amino]-alpha-L-xylo-heptofuranuronate - 72046 6.5.1.2 ethyl-3-O-benzyl-5-[benzyl[(4-chlorophenyl)carbamoyl]amino]-5,6-dideoxy-1,2-O-(1-methylethylidene)-alpha-L-xylo-heptofuranuronate - 72047 6.5.1.2 hydroxychloroquine specific inhibitor of the Escherichia coli enzyme 38397 6.5.1.2 hydroxychloroquine - 38397 6.5.1.2 KCl inhibition by KCl occurs at greater than 30 mM (NH4)2SO 79 6.5.1.2 methotrexate IC50 of 0.008 mg/ml 241 6.5.1.2 mitonafide i.e. 3-nitro-N-(2-(dimethylamino)ethyl)-1,8-naphthalimide 147502 6.5.1.2 Mn2+ activation at 0.2-1.0 mM, inhibition at higher concentration 11 6.5.1.2 additional information not inhibited by trimethoprim 2 6.5.1.2 additional information not inhibited by cinchonidine, quinine, and N,N'-bis[4chloroquinolin-8-yl]succinamide 2 6.5.1.2 N'-(6-chloro-2-methoxyacridin-9-yl)-N,N-diethylbutane-1,4-diamine - 165570 6.5.1.2 N'-(6-chloro-2-methoxyacridin-9-yl)-N,N-dimethylbutane-1,4-diamine - 165569 6.5.1.2 N,N'-bis[4-((4-(diethylamino)-1-methylbutyl)amino)-quinoline-6-yl]sebacamide powerful inhibitor, exhibits good inhibition at nanomolar concentrations 72035 6.5.1.2 N,N'-bis[4-((4-(diethylamino)-1-methylbutyl)amino)-quinoline-8-yl]adipamide powerful inhibitor, exhibits good inhibition at nanomolar concentrations 72036 6.5.1.2 N,N'-bis[[(3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]methyl]dodecane-1,12-diamine - 72043 6.5.1.2 N,N-bis(4-aminobutyl)-N'-(6-chloro-2-methoxyacridin-9-yl)butane-1,4-diamine - 165574 6.5.1.2 N,N-bis(4-aminobutyl)-N'-(6-chloro-2-methoxyacridin-9-yl)pentane-1,5-diamine - 165576 6.5.1.2 N-(4-aminobutyl)-N-(3-aminopropyl)-N'-(6-chloro-2-methoxyacridin-9-yl)butane-1,4-diamine - 165573 6.5.1.2 N-(4-aminobutyl)-N-(3-aminopropyl)-N'-(6-chloro-2-methoxyacridin-9-yl)pentane-1,5-diamine - 165575 6.5.1.2 N-(4-aminobutyl)-N-[3-[(6-chloro-2-methoxyacridin-9-yl)amino]propyl]butane-1,4-diamine - 165577 6.5.1.2 N-(6-chloro-2-methoxyacridin-9-yl)butane-1,4-diamine - 165572 6.5.1.2 N-[6-piperidin-1-ylhexyl]-6,7-dihydrobenzo[b]indolo[2,3-d]thiepine LX competes with NAD+ andf inhibits the enzyme with IC50 in the low micromolar range, LX exhibits around 15fold better inhibition of the Mycobacterium tuberculosis enzyme compared to the human DNA ligase 147594 6.5.1.2 N1,N1-bis(2-chloroethyl)-N4-(6-chloro-2-methoxyacridin-9-yl)pentane-1,4-diamine - 165582 6.5.1.2 N1-(7-chloro-[4]quinolyl)-N4,N4-bis-(2-hydroxy-ethyl)-1-methyl-butanediyldiamine IC50: 0.046 mM 57554 6.5.1.2 N4-(7-chloro-7,8-dihydroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine - 72048 6.5.1.2 N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentame-1,4-diamine - 66870 6.5.1.2 Na+ above 20-150 mM 59 6.5.1.2 NAD+ inhibitory above 0.1 mM, activity is abolished at 0.5 mM 7 6.5.1.2 nicotinamide mononucleotide - 1831 6.5.1.2 pinafide i.e. 3-nitro-N-(2-(1-pyrrolidinyl)ethyl)-1,8-naphthalimide 227955 6.5.1.2 putrescine - 155 6.5.1.2 pyridochromanone IC50: 0.0006 mM 57911 6.5.1.2 pyridochromanones differently substituted compounds tested and all found to be inhibitory, competitive with NAD+, inhibitory in nano-molar rage without affecting human DNA-ligase (ATP-depentend) activity 118767 6.5.1.2 Quinacrine powerful inhibitor, exhibits good inhibition at nanomolar concentrations 1593 6.5.1.2 Quinacrine - 1593 6.5.1.2 Rp-cAMPS - 135726 6.5.1.2 Sp-cAMPS - 135725 6.5.1.2 tert-butyl 3-(7-amino-3-bromo-6-carbamoyl-1,8-naphthyridin-2-yl)azetidine-1-carboxylate - 193896