5.6.1.3 ((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methanamine - 81977 5.6.1.3 (1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)(1-methylpiperidin-3-yl)methanone - 82254 5.6.1.3 (2R)-2-amino-1-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-3-methylbutan-1-one - 81955 5.6.1.3 (2R)-2-amino-3-((1,1,2-triphenylethyl)sulfanyl)propanoic acid - 75993 5.6.1.3 (2R)-2-amino-3-((1,1-bis(4-chlorophenyl)-2-phenylethyl)sulfanyl)propanoic acid - 87015 5.6.1.3 (2R)-2-amino-3-((1,1-bis(4-fluorophenyl)-2-phenylethyl)sulfanyl)propanoic acid - 87014 5.6.1.3 (2R)-2-amino-3-((1,1-bis(4-methylphenyl)-2-phenylethyl)sulfanyl)propanoic acid - 87016 5.6.1.3 (2R)-2-amino-3-((1-(2-fluorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid - 59402 5.6.1.3 (2R)-2-amino-3-((1-(3,4-dichlorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid - 86988 5.6.1.3 (2R)-2-amino-3-((1-(3-chlorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid - 59403 5.6.1.3 (2R)-2-amino-3-((1-(3-chlorophenyl)-1-(4-chlorophenyl)-2-phenylethyl)sulfanyl)propanoic acid - 87013 5.6.1.3 (2R)-2-amino-3-((1-(3-hydroxyphenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid - 69581 5.6.1.3 (2R)-2-amino-3-((1-(4-chlorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid - 86979 5.6.1.3 (2R)-2-amino-3-((1-(4-fluorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid - 67043 5.6.1.3 (2R)-2-amino-3-((1-(4-hydroxyphenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid - 87003 5.6.1.3 (2R)-2-amino-3-((1-(4-methylphenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid - 87040 5.6.1.3 (2R)-2-amino-3-((2-(3,4-chlorophenyl)-1,1-diphenylethyl)sulfanyl)propanoic acid - 59399 5.6.1.3 (2R)-2-amino-3-((2-(3-chlorophenyl)-1,1-diphenylethyl)sulfanyl)propanoic acid - 59397 5.6.1.3 (2R)-2-amino-3-((2-(4-chlorophenyl)-1,1-diphenylethyl)sulfanyl)propanoic acid - 67215 5.6.1.3 (2R)-2-amino-3-[(1,1,3-triphenylpropyl)sulfanyl]propanoic acid - 67040 5.6.1.3 (2R,4aS,5R,10bS)-2-((1H-1,2,4-triazol-1-yl)methyl)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82427 5.6.1.3 (2S)-2-amino-1-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-3-methylbutan-1-one - 82423 5.6.1.3 (4aS,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 81840 5.6.1.3 (4aS,10bS)-9-(tert-butyl)-5-(3-chlorophenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82148 5.6.1.3 (4aS,10bS)-9-(tert-butyl)-5-(3-fluorophenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82169 5.6.1.3 (4aS,10bS)-9-(tert-butyl)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 81851 5.6.1.3 (4aS,5R,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 81834 5.6.1.3 (4aS,5R,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-9-carbonitrile - 82145 5.6.1.3 (4aS,5R,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-9-carboxylic acid - 81856 5.6.1.3 (4aS,5R,10bS)-5-phenyl-9-(trifluoromethoxy)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82411 5.6.1.3 (4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82480 5.6.1.3 (4aS,5R,10bS)-5-phenyl-9-propyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82476 5.6.1.3 (4aS,5R,10bS)-7,9-dimethyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82141 5.6.1.3 (4aS,5R,10bS)-7-fluoro-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82255 5.6.1.3 (4aS,5R,10bS)-8,10-dimethyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82109 5.6.1.3 (4aS,5R,10bS)-8,9-dimethyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82226 5.6.1.3 (4aS,5R,10bS)-8-(tert-butyl)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82090 5.6.1.3 (4aS,5R,10bS)-8-chloro-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 81787 5.6.1.3 (4aS,5R,10bS)-9-(pentafluoro-lambda6-sulfanyl)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82337 5.6.1.3 (4aS,5R,10bS)-9-(tert-butyl)-5-(1H-imidazol-2-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82113 5.6.1.3 (4aS,5R,10bS)-9-(tert-butyl)-5-(2-fluorophenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 81936 5.6.1.3 (4aS,5R,10bS)-9-(tert-butyl)-5-(3-chlorophenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82000 5.6.1.3 (4aS,5R,10bS)-9-(tert-butyl)-5-(3-fluoro-4-methoxyphenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82007 5.6.1.3 (4aS,5R,10bS)-9-(tert-butyl)-5-(3-fluorophenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 81865 5.6.1.3 (4aS,5R,10bS)-9-(tert-butyl)-5-(4-fluorophenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 81820 5.6.1.3 (4aS,5R,10bS)-9-(tert-butyl)-5-(pyridin-3-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 81983 5.6.1.3 (4aS,5R,10bS)-9-(tert-butyl)-5-(thiazol-2-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82472 5.6.1.3 (4aS,5R,10bS)-9-(tert-butyl)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82285 5.6.1.3 (4aS,5R,10bS)-9-chloro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82370 5.6.1.3 (4aS,5R,10bS)-9-ethyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82072 5.6.1.3 (4aS,5R,10bS)-9-isopropyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82214 5.6.1.3 (4aS,5R,10bS)-9-methyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82068 5.6.1.3 (4aS,5R,10bS)-N,N-dimethyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-amine - 82212 5.6.1.3 (4aS,5S,10bS)-9-(tert-butyl)-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline - 82433 5.6.1.3 1-((2R,4aS,5R,10bS)-5-(4-fluorophenyl)-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)-N-methylmethanamine - 81795 5.6.1.3 1-((2R,4aS,5R,10bS)-9-(tert-butyl)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)-N-methylmethanamine - 82155 5.6.1.3 1-((2R,4aS,5R,10bS)-9-bromo-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)-N-methylmethanamine - 81789 5.6.1.3 1-((2R,4aS,5R,10bS)-9-cyclopropyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)-N-methylmethanamine - 82415 5.6.1.3 1-(1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone i.e. tetrahydro-beta-carboline 82333 5.6.1.3 1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-3-(piperidin-1-yl)propan-1-one - 81953 5.6.1.3 1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone - 81830 5.6.1.3 1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one - 82121 5.6.1.3 1-(2-(dimethylamino)ethyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)urea - 81976 5.6.1.3 1-(3,6-dibromo-9H-carbazol-9-yl)-3-phenethylamino-2-propanol - 138588 5.6.1.3 1-(3,6-dichloro-9H-carbazol-9-yl)-3-phenethylamino-2-propanol induces cell death 138589 5.6.1.3 1-(3-hydroxypropyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)urea - 82263 5.6.1.3 1-(4'-tert-butylbiphenyl-4-yl)urea - 65306 5.6.1.3 1-(4'-[(trifluoromethyl)sulfonyl]biphenyl-4-yl)urea - 65305 5.6.1.3 1-(4-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)phenyl)ethanone - 81975 5.6.1.3 1-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-2-(piperidin-4-yl)ethanone - 82206 5.6.1.3 1-(benzenesulfinyl)-2,4-dinitrobenzene - 204809 5.6.1.3 1-(benzenesulfinyl)-2-nitrobenzene - 204810 5.6.1.3 1-(benzenesulfonyl)-2,4-dinitrobenzene - 204811 5.6.1.3 1-(benzenesulfonyl)-2-nitro-4-(trifluoromethyl)benzene - 204812 5.6.1.3 1-(benzenesulfonyl)-2-nitrobenzene - 204813 5.6.1.3 1-(benzenesulfonyl)-4-chloro-2-nitrobenzene i.e. BTB-1, reversibly inhibits the microtubule-stimulated ATPase activity of Kif18A 204814 5.6.1.3 1-(benzenesulfonyl)-4-fluoro-2-nitrobenzene - 204815 5.6.1.3 1-phenethylamino-3-phenothiazin-10-yl-propan-2-ol induces strong mitotic arrest followed by cell death. More than 90% of cells exhibit the monoastral spindle instead of the normal mitotic spindle. Inhibitor selectively kills transformed culture cells; the inhibitor selectively kills transformed cell cultures 35859 5.6.1.3 1-[(4-chlorophenyl)methanesulfonyl]-2,4-dinitrobenzene - 204840 5.6.1.3 1-[(4-methoxyphenyl)methanesulfinyl]-2-nitrobenzene - 204841 5.6.1.3 1-[(4-methoxyphenyl)methanesulfonyl]-2-nitrobenzene - 204842 5.6.1.3 1-[(4-methylphenyl)methanesulfinyl]-2,4-dinitrobenzene - 204843 5.6.1.3 1-[(4-methylphenyl)methanesulfonyl]-2,4-dinitrobenzene - 204844 5.6.1.3 1-[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]urea - 65335 5.6.1.3 1-[3'-nitro-4'-(trifluoromethyl)biphenyl-4-yl]urea - 65336 5.6.1.3 1-[3-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]urea - 65337 5.6.1.3 1-[4'-(propan-2-yl)biphenyl-4-yl]urea - 65338 5.6.1.3 1-[4'-(trifluoromethyl)biphenyl-4-yl]thiourea - 65339 5.6.1.3 1-[4'-(trifluoromethyl)biphenyl-4-yl]urea - 65340 5.6.1.3 1-[4-(1,3-benzodioxol-5-yl)phenyl]urea - 65341 5.6.1.3 1-[4-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]urea - 65342 5.6.1.3 2-((((2R,4aS,5R,10bS)-9-(tert-butyl)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)(ethyl)amino)ethanol - 82052 5.6.1.3 2-((((2R,4aS,5R,10bS)-9-chloro-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)amino)ethanol - 82137 5.6.1.3 2-((1,1,2-triphenylethyl)sulfanyl)ethanaminium tetrafluoroborate - 72248 5.6.1.3 2-((1,1-bis(4-chlororophenyl)-2-phenylethyl)sulfanyl)ethanamine - 87019 5.6.1.3 2-((1,1-bis(4-fluorophenyl)-2-phenylethyl)sulfanyl)ethanamine - 87018 5.6.1.3 2-((1,1-bis(4-methylphenyl)-2-phenylethyl)sulfanyl)ethanamine - 87020 5.6.1.3 2-((1-(2-fluorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine - 87005 5.6.1.3 2-((1-(3,4-dichlorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine - 87002 5.6.1.3 2-((1-(3-chlorophenyl)-1,2-diphenylethyl)sulfanyl)ethanaminium tetrafluoroborate - 86977 5.6.1.3 2-((1-(3-chlorophenyl)-1-(4-chlorophenyl)-2-phenylethyl)sulfanyl)ethanamine - 87017 5.6.1.3 2-((1-(3-hydroxyphenyl)-1,2-diphenylethyl)sulfanyl)ethanamine - 87007 5.6.1.3 2-((1-(4-chlorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine - 87009 5.6.1.3 2-((1-(4-fluorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine - 87008 5.6.1.3 2-((1-(4-hydroxylphenyl)-1,2-diphenylethyl)sulfanyl)ethanamine - 87011 5.6.1.3 2-((1-(4-methylphenyl)-1,2-diphenylethyl)sulfanyl)ethanamine - 87021 5.6.1.3 2-((2R,4aS,5R,10bS)-9-(tert-butyl)-2-((methylamino)methyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)benzenethiol - 81910 5.6.1.3 2-((4aS,5R,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-yl)acetonitrile - 82492 5.6.1.3 2-((4aS,5R,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-yl)ethanol - 82430 5.6.1.3 2-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)-4-chlorobenzenethiol - 81923 5.6.1.3 2-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)benzenethiol - 82179 5.6.1.3 2-((diphenyl(pyridin-4-yl)methyl)sulfanyl)ethanamine - 59401 5.6.1.3 2-(2,4-difluorophenyl)-9-(3,4-dimethylphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide - 86995 5.6.1.3 2-(2-sulfanylethoxy)ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate - 36870 5.6.1.3 2-(4-chloro-2-nitrobenzene-1-sulfinyl)naphthalene - 204920 5.6.1.3 2-(4-chloro-2-nitrobenzene-1-sulfonyl)thiophene - 204921 5.6.1.3 2-(dimethylamino)ethyl (((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)carbamate - 82272 5.6.1.3 2-(methylamino)-N-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)ethanesulfonothioamide - 81958 5.6.1.3 2-(tritylthio)ethanamine - 59400 5.6.1.3 2-amino-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone - 82331 5.6.1.3 2-[1-(4-methoxyphenyl)-5-oxo-3-[2-(thiophen-2-yl)ethyl]-2-thioxoimidazolidin-4-yl]-N-phenylacetamide - 87010 5.6.1.3 2-[2-(acetylsulfanyl)ethoxy]ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate - 36871 5.6.1.3 3-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)aniline - 81904 5.6.1.3 3-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)benzenethiol - 82077 5.6.1.3 3-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)phenol - 81854 5.6.1.3 3-(2-((2-aminoethyl)sulfonyl)-6-chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenol - 82191 5.6.1.3 3-(dimethylamino)-N-(((2R,4aS,5R,10bS)-9-isopropyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)propane-1-sulfonamide - 82349 5.6.1.3 3-amino-1-(1-(2-aminopyridin-4-yl)-6-chloro-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one - 81811 5.6.1.3 3-amino-1-(1-(3-fluorophenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one - 81852 5.6.1.3 3-amino-1-(1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one - 81833 5.6.1.3 3-amino-1-(1-(3-hydroxyphenyl)-6-(trifluoromethoxy)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one - 82350 5.6.1.3 3-amino-1-(1-(3-hydroxyphenyl)-6-isopropyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one - 82125 5.6.1.3 3-amino-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one - 40767 5.6.1.3 3-amino-1-(1-(3-hydroxyphenyl)-6-phenyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one - 82431 5.6.1.3 3-amino-1-(1-(3-methoxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one - 81965 5.6.1.3 3-amino-1-(6-bromo-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one - 81935 5.6.1.3 3-amino-1-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one - 82354 5.6.1.3 3-amino-1-(6-chloro-1-cyclohexyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one - 81893 5.6.1.3 3-amino-1-(6-ethyl-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one - 81960 5.6.1.3 3-amino-1-(6-fluoro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one - 82292 5.6.1.3 3-amino-1-(6-hydroxy-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one - 81858 5.6.1.3 3-amino-1-(6-methyl-1-phenyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one - 82151 5.6.1.3 3-amino-N-methyl-N-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)propane-1-sulfonothioamide - 82098 5.6.1.3 4'-(trifluoromethyl)biphenyl-4-yl sulfamate - 65472 5.6.1.3 4-((((2R)-2-ammonio-2-carboxyethyl)sulfanyl)(diphenyl)-methyl)pyridinium tetrafluoroborate - 67207 5.6.1.3 4-((2R,4aS,5R,10bS)-2-((methylamino)methyl)-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)phenol - 81981 5.6.1.3 4-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)-2-fluorophenol - 82075 5.6.1.3 4-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)benzene-1,2-diol - 82485 5.6.1.3 4-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)phenol - 82463 5.6.1.3 4-((4aS,5S,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)butan-1-ol - 82376 5.6.1.3 4-(2-[1-(2,4,6-trifluorophenyl)cyclopropyl]-1,3-thiazol-4-yl)pyridine - 65497 5.6.1.3 4-(2-[1-(2,4-difluorophenyl)cyclopropyl]-1,3-thiazol-4-yl)pyridine - 65498 5.6.1.3 4-(2-[1-(2,6-difluorophenyl)cyclopropyl]-1,3-thiazol-4-yl)pyridine - 65499 5.6.1.3 4-(2-[1-(2-fluorophenyl)cyclopropyl]-1,3-thiazol-4-yl)pyridine - 65500 5.6.1.3 4-(2-[1-(4-chlorophenyl)cyclopropyl]-1,3-thiazol-4-yl)pyridine - 65501 5.6.1.3 4-(2-[1-(4-fluorophenyl)cyclopropyl]-1,3-thiazol-4-yl)pyridine treatmebnt of cells results in inhibition of proliferation and induction of caspase 3 activity with EC50 values of 0.0017 and 0.0011 mM, respectively. Compound induces monoastral spindles in A2780 cells when incubated at concentrations above that required to induce a full mitotic arrest 65502 5.6.1.3 4-(benzenesulfonyl)-1-chloro-2-nitrobenzene - 205143 5.6.1.3 4-amino-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)butan-1-one - 82436 5.6.1.3 4-chloro-1-(4-methoxybenzene-1-sulfinyl)-2-nitrobenzene - 205165 5.6.1.3 4-chloro-1-[(4-chlorophenyl)methanesulfonyl]-2-nitrobenzene - 205166 5.6.1.3 4-chloro-1-[(4-methoxyphenyl)methanesulfonyl]-2-nitrobenzene - 205167 5.6.1.3 4-chloro-1-[(4-methylphenyl)methanesulfonyl]-2-nitrobenzene - 205168 5.6.1.3 4-chloro-2-nitro-1-phenoxybenzene - 205169 5.6.1.3 4-[2-(1-phenylcyclopropyl)-1,3-thiazol-4-yl]pyridine 1-oxide - 65544 5.6.1.3 4-[[3-(methoxycarbonyl)-2-methyl-5a,9a-dihydronaphtho[1,2-b]furan-5-yl]sulfamoyl]benzoic acid - 86997 5.6.1.3 5-(2-(3-aminopropanoyl)-6-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)benzo[d]oxazol-2(3H)-one - 82147 5.6.1.3 5-(2-fluorophenyl)-2,9-dimethyl-5,6-dihydropyrazolo[1,5-c]quinazoline - 86996 5.6.1.3 5-[2-(1-phenylcyclopropyl)-1,3-thiazol-4-yl]pyridine-2-carbonitrile - 65586 5.6.1.3 6-(4-chloro-2-nitrobenzene-1-sulfonyl)-1,4-dihydronaphthalene - 205348 5.6.1.3 6-[4-(trifluoromethyl)phenyl]-3,4-dihydroquinolin-2(1H)-one - 14169 5.6.1.3 actin inhibition in the presence of microtubles 796 5.6.1.3 adenosine 5'-[beta,gamma-imido]triphosphate nonhydrolyzable analogue of ATP, blocks enzyme by rapid replacement of ATP 8034 5.6.1.3 adenylylimidodiphosphate AMP-PNP 92313 5.6.1.3 ADP - 13 5.6.1.3 AMP-PNP binding structure 4099 5.6.1.3 BTB-1 BTB-1 inhibits both of the microtubule-based Kif18A activities. Allosteric BTB-1-binding site near loop5, where it blocks the ATP-dependent conformational changes 232856 5.6.1.3 Calmodulin activated calmodulin inhibits KCBP interaction with microtubules thereby abolishing its motor- and microtubules-dependent ATPase activity 125 5.6.1.3 docetaxel - 9989 5.6.1.3 ethyl 3-acetyl-4-[3-(acetyloxy)phenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate no inhibition in vitro, inhibitory in cell-based assay 65724 5.6.1.3 ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate i.e. monastrol 24881 5.6.1.3 ethyl 4-[3-(acetyloxy)phenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate no inhibition in vitro, inhibitory in cell-based assay 65727 5.6.1.3 furan-2-yl[4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl]methanone - 24883 5.6.1.3 ispinesib SB-715992, a potent and selective inhibitor of kinesin spindle protein 69319 5.6.1.3 kinesin spindle protein activator-1 inhibits kinesin spindle protein ATP turnover in the presence of microtubules 75616 5.6.1.3 monastrol 0.2 mM, 25% inhibition. Compared to vertebrate Eg5, Eh Klp5 is less sensitive to monastrol 17625 5.6.1.3 monastrol model for dimeric Eg5 in which monastrol stabilizes a conformation with the neck linker of each motor domain locked onto its catalytic core, resulting in dissociation of the MT. Eg5 complex or an inhibition of MT binding 17625 5.6.1.3 monastrol suppresses the directional processive motility of microtubule-bound Eg5 17625 5.6.1.3 additional information synthetic peptides derived from the tail of kinesin inhibit the protein's ATPase and motor activities. A peptide that spans residues 904-933 exhibits the strongest inhibitory effect on steady-state motility and ATPase activity, reflecting diminished binding of the ADP-bound kinesin head to the microtubule. Tail-mediated inhibition of kinesin activity is mainly the product of allosteric inhibition induced by the intramolecular binding of kinesin tail domain to the motor domain 2 5.6.1.3 additional information study of the discovery and optimization of hexahydro-2H-pyranol[3,2-c]quinolines, HHPQs, as inhibitors. Crystallographic data demonstrate that these potent and selectve inhibitors bind in an allosteric pocket of kinesin-5 distant from the nucleotide and microtubule binding sites; the activity assay for inhibition analysis are performed with a coupled ATP regeneration system with a total concentration of the kinesin-5 protein of approximately 50 nM in the reaction 2 5.6.1.3 additional information development of small molecule inhibitors of the enzyme Kif11 ATPase activity 2 5.6.1.3 additional information identification of optimized small molecule inhibitors of the mitotic kinesin Kif18A, usage of BTB-1 as a lead compound, structure-activity relationship studies and inhibition mechanism of BTB-1 and its analogues, overview 2 5.6.1.3 additional information kinesin performs autoinhibition, addition of a negative charge at Ser175 favors the autoinhibited conformation of kinesin 2 5.6.1.3 N-(((2R,4aS,5R,10bS)-9-bromo-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)-4-(dimethylamino)butanamide - 82306 5.6.1.3 N-(((2R,4aS,5R,10bS)-9-chloro-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)-2-(dimethylamino)ethanesulfonamide - 82450 5.6.1.3 N-(2-((((2R,4aS,5R,10bS)-9-bromo-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)amino)ethyl)acetamide - 82490 5.6.1.3 N-(2-aminoethyl)-4-methyl-N-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)benzamide - 82289 5.6.1.3 N-(3-(2-(3-aminopropanoyl)-6-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)methanesulfonamide - 82250 5.6.1.3 N-(3-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-3-oxopropyl)methanesulfonamide - 82172 5.6.1.3 N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl]-3-fluoro-4-methylbenzamide - 36898 5.6.1.3 N-(4-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)phenyl)acetamide - 82130 5.6.1.3 N-(4-fluorophenyl)-2-[1-(4-fluorophenyl)-3-[2-(3-methylthiophen-2-yl)ethyl]-5-oxo-2-thioxoimidazolidin-4-yl]acetamide - 86993 5.6.1.3 N-(4-methoxyphenyl)-2-[3-[2-(3-methylthiophen-2-yl)ethyl]-5-oxo-1-phenyl-2-thioxoimidazolidin-4-yl]acetamide - 86994 5.6.1.3 N-ethylmaleimide - 49 5.6.1.3 N-[3-amino-4'-(trifluoromethyl)biphenyl-4-yl]sulfuric diamide - 65936 5.6.1.3 N-[3-chloro-4'-(trifluoromethyl)biphenyl-4-yl]sulfuric diamide - 65937 5.6.1.3 N-[3-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]sulfuric diamide - 24915 5.6.1.3 N-[3-methoxy-4'-(trifluoromethyl)biphenyl-4-yl]sulfuric diamide - 65938 5.6.1.3 N-[4'-(trifluoromethyl)biphenyl-4-yl]methanesulfonamide - 36903 5.6.1.3 N-[4'-(trifluoromethyl)biphenyl-4-yl]sulfuric diamide - 24916 5.6.1.3 N1-phenyl-N1-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)ethane-1,2-diamine - 82496 5.6.1.3 PVZB1194 allosteric inhibitor, biphenyl-type inhibitor, binding structure of the inhibitor in complex with the Eg5 motor domain: inhibitor PVZB1194 binds to the alpha4/alpha6 allosteric pocket 15 A from the ATP-binding pocket, which differs from conventional allosteric inhibitors that bind to the allosteric L5/alpha2/alpha 3 pocket of Eg5. Binding of the inhibitor is involved in the neck-linker conformation and also causes conformational changes around the ATP-binding pocket through Tyr104 to affect the interaction of ATP with the pocket. Folding rearrangement of enzyme Eg5 induced by PVZB1194 in the absence of nucleotides and microtubules. Residue Tyr104 is involved in ATP-competitive inhibition by PVZB1194 71150 5.6.1.3 S-trityl-L-cysteine tight binding inhibitor, specific for kinesin Eg5. Inhibits Eg5-driven microtubule sliding velocity in a reversible fashion with a IC50 of 500 nM. The S and D-enantiomers of tritylcysteine are nearly equally potent. No inhibition of KIF2A/Kif2 (kinesin-13 family), KIF2C/MCAK (kinesin-13 family), KIF5B/HsuKHC (kinsin-1 family), KIF19/HsCENP-E (kinesin-7 family), KIF20A/HsRabK6 (kinsin-6 family), KIF22A/HsKid (kinesin-10 family), KIF23/HsMKLP1 (kinesin-6 family), KIFC1/HsKIFC1 (kinesin-14 family) 24149 5.6.1.3 S-trityl-L-cysteine - 24149 5.6.1.3 SB-731489 - 37852 5.6.1.3 V5+ - 13227