5.1.1.4 (E)-4-oxopent-2-enoic acid an irreversible strong competitive inhibitor, which hampers Trypanosoma cruzi intracellular differentiation and fate in mammalian host cells 194451 5.1.1.4 (E)-5-bromo-4-oxopent-2-enoic acid an irreversible strong competitive inhibitor, which hampers Trypanosoma cruzi intracellular differentiation and fate in mammalian host cells 194452 5.1.1.4 1,10-phenanthroline - 62 5.1.1.4 1-carboxy-7-azoniabicyclo[2.2.1]heptane a weak inhibitor 192674 5.1.1.4 2-Furoic acid weak 43130 5.1.1.4 2-pyrrolecarboxylic acid - 176547 5.1.1.4 2-Thiophenecarboxylic acid - 91195 5.1.1.4 4-bromopyrazole-3-carboxylic acid - 194455 5.1.1.4 4-chloro-5-methyl-pyrazole-3-carboxylic acid - 194457 5.1.1.4 4-chloropyrazole-3-carboxylic acid - 194454 5.1.1.4 4-ethylpyrazole-3-carboxylic acid - 194456 5.1.1.4 7-azabicyclo[2.2.1]heptan-7-ium-1-carboxylate a weak inhibitor of proline racemase, 29% inhibition at 142.5 mM 194458 5.1.1.4 alpha-Pipecoline - 92421 5.1.1.4 Asp - 304 5.1.1.4 Bromoacetate - 3803 5.1.1.4 DELTA1-pyrroline-2-carboxylate - 3627 5.1.1.4 Fumaric acid - 6524 5.1.1.4 HPO42- no inhibition by H2PO4- 2843 5.1.1.4 iodoacetamide - 67 5.1.1.4 iodoacetate DL-Pro and pyrrole-2-carboxylate can protect 93 5.1.1.4 iodoacetate - 93 5.1.1.4 lipoic acid weak 2025 5.1.1.4 Maleic acid - 4029 5.1.1.4 malonic acid - 10708 5.1.1.4 Methoxyacetic acid weak 94030 5.1.1.4 additional information substrate-product analogue inhibitors of racemases may only be effective when the active site is capacious and/or plastic, or when the inhibitor is sufficiently flexible 2 5.1.1.4 additional information synthesized soluble pyrazole derivatives prove to be weak or inactive TcPRAC inhibitors 2 5.1.1.4 Phthalic acid - 3662 5.1.1.4 pipecolic acid weak 44713 5.1.1.4 pyrazole-3-carboxylic acid - 194453 5.1.1.4 pyrrole-2-carboxylate - 4860 5.1.1.4 pyrrole-2-carboxylic acid - 6642 5.1.1.4 pyrrole-2-carboxylic acid PYC, competitive inhibitor 6642 5.1.1.4 pyrrole-2-carboxylic acid inhibitor significantly affects parasite infection of Vero cells in vitro, inhibitor also hampers Trypanosoma cruzi intracellular differentiation, inhibitor reduces host cell invasion in Vero cells by Trypanososma cruzi in a dose-dependent manner, pre-treatment of the parasites with 1 mM of inhibitor does not lead to changes in their morphology and motility, but results in an up to 54% reduction in the percentage of parasitized cells and about 30% less parasites per cell when cultures are counted at day 4 after infection 6642 5.1.1.4 pyrrole-2-carboxylic acid competitive inhibitor 6642 5.1.1.4 reduced glutathione weak 593 5.1.1.4 sarcosine - 594 5.1.1.4 succinic acid - 2759 5.1.1.4 tetrahydro-1H-pyrrolizine-7a(5H)-carboxylate a bicyclic substrate-product analogue and noncompetitive inhibitor of proline racemase 194459 5.1.1.4 Tetrahydrofuroic acid weak 95152 5.1.1.4 thioglycolate weak 3098