4.1.1.112 2-oxoglutarate 2 mM inhibitor in presence of 10 mM Mn2+, 11% inhibition 34 4.1.1.112 3,3-difluoroxaloacetate - 6942 4.1.1.112 5,5'-dithiobis(2-nitrobenzoate) - 303 4.1.1.112 acetate competitive for oxaloacetate, Ki: 12 mM 47 4.1.1.112 acetic acid noncompetitive 751 4.1.1.112 Acetopyruvate - 5925 4.1.1.112 ADP Ki: 1.5 mM 13 4.1.1.112 ADP Ki: 1.2 mM 13 4.1.1.112 ADP competitive 13 4.1.1.112 ADP 78% residual activity at 0.25 mM 13 4.1.1.112 alpha-ketovalerate - 7147 4.1.1.112 ATP carboxylation competitively inhibited, decarboxylation non-competitively, Ki: 2.2 mM, possibly involved in regulation 4 4.1.1.112 ATP Ki: 1.5 mM 4 4.1.1.112 ATP complete inhibition at 8-9 mM 4 4.1.1.112 ATP 37% residual activity at 1 mM 4 4.1.1.112 Avidin not 1224 4.1.1.112 azide 2 mM, 20% inhibition 230 4.1.1.112 Ca2+ 2 mM inhibitor in presence of 1 mM Mn2+, 30% inhibition 15 4.1.1.112 citrate 50% inhibition of mitochondrial enzyme at 4.5 mM 131 4.1.1.112 citrate - 131 4.1.1.112 citrate 0.5 mM inhibitor or 2 mM inhibitor in presence of 10 mM Mn2+, 24% inhibition 131 4.1.1.112 citrate 74% residual activity at 2 mM 131 4.1.1.112 coenzyme A 50% inhibition of mitochondrial enzyme at 0.05 mM 534 4.1.1.112 coenzyme A Ki: 2.4 mM 534 4.1.1.112 Cu2+ - 19 4.1.1.112 Cu2+ Ki: 0.2 mM 19 4.1.1.112 Cu2+ 2 mM, 45% inhibition 19 4.1.1.112 Cu2+ 0.5 mM inhibitor in presence of 1 mM Mn2+, complete inhibition 19 4.1.1.112 EDTA inhibition of residual activity without divalent metal ions 21 4.1.1.112 EDTA - 21 4.1.1.112 EDTA 2 mM, 100% inhibition 21 4.1.1.112 EDTA 10 mM, complete inhibition 21 4.1.1.112 EDTA complete inhibition at 2 mM 21 4.1.1.112 fumarate 2 mM inhibitor in presence of 10 mM Mn2+, 21% inhibition 170 4.1.1.112 glycine-NaOH - 31035 4.1.1.112 Hg2+ - 33 4.1.1.112 hydrogencarbonate - 32902 4.1.1.112 L-malate competitive for oxaloacetate, Ki: 4.5 mM 247 4.1.1.112 malate 2 mM inhibitor in presence of 10 mM Mn2+, 54% inhibition 283 4.1.1.112 malate 65% residual activity at 2 mM 283 4.1.1.112 malic acid competitive 15837 4.1.1.112 malonate - 392 4.1.1.112 malonate 0.5 mM inhibitor in presence of 10 mM Mn2+, 84% inhibition 392 4.1.1.112 malonate 26% residual activity at 2 mM 392 4.1.1.112 Mn2+ at concentrations higher than 0.4 mM 11 4.1.1.112 Mn2+ inhibitory above 0.46 mM 11 4.1.1.112 additional information no effect is observed after addition of ADP (2.4 mM), GDP (3.6 mM), or succinate (5.6 mM) or after addition of phosphoenolpyruvate, L-fructose-6-phosphate, L-fructose-1,6-bisphosphate, L-malate, acetate, citrate, fumarate, L-aspartate, or acetyl coenzyme A (5 mM each) 2 4.1.1.112 additional information not inhibited by succinate 2 4.1.1.112 N-ethylmaleimide - 49 4.1.1.112 N-ethylmaleimide 2 mM, 14% inhibition 49 4.1.1.112 NaCl almost complete inhibition at 0.4 M 42 4.1.1.112 NaCl OAD tertiary structure is sensitive to the presence of NaCl 42 4.1.1.112 NAD+ 2 mM inhibitor in presence of 10 mM Mn2+, complete inhibition 7 4.1.1.112 NAD+ 40% residual activity at 0.25 mM 7 4.1.1.112 NADH 2 mM inhibitor in presence of 10 mM Mn2+, complete inhibition 8 4.1.1.112 NADH 53% residual activity at 0.25 mM 8 4.1.1.112 Ni2+ 2 mM inhibitor in presence of 1 mM Mn2+, 40% inhibition 38 4.1.1.112 oxalate - 185 4.1.1.112 oxalate half-maximal inhibition at 0.01 mM 185 4.1.1.112 oxalate 0.5 mM inhibitor in presence of 10 mM Mn2+, 80% inhibition 185 4.1.1.112 oxalate 14% residual activity at 2 mM 185 4.1.1.112 oxalate potent competitive inhibition 185 4.1.1.112 oxalate competitive inhibitor 185 4.1.1.112 oxalic acid competitive 2093 4.1.1.112 oxomalonate half-maximal inhibition at 0.2 mM 10742 4.1.1.112 oxomalonate competitive inhibitor of OAD with respect to oxaloacetate 10742 4.1.1.112 p-chloromercuribenzoate - 43 4.1.1.112 p-chloromercuribenzoate 50% inhibition at 0.5 mM 43 4.1.1.112 p-chloromercuribenzoate 2 mM, 62% inhibition 43 4.1.1.112 p-hydroxymercuribenzoate complete inactivation after preincubation at 0.2 mM 98 4.1.1.112 p-hydroxymercuribenzoate partly prevented by NADP+ 98 4.1.1.112 phosphate - 16 4.1.1.112 phosphoenolpyruvate 50% inhibition of mitochondrial enzyme at 28 mM 51 4.1.1.112 phosphoenolpyruvate competitive 51 4.1.1.112 Phosphonopyruvate - 2044 4.1.1.112 pyruvate - 31 4.1.1.112 pyruvate 2 mM inhibitor in presence of 10 mM Mn2+, 8% inhibition 31 4.1.1.112 succinate - 58 4.1.1.112 succinate 2 mM inhibitor in presence of 10 mM Mn2+, 23% inhibition 58 4.1.1.112 Zn2+ 54% inhibition at 1.5 mM 14 4.1.1.112 Zn2+ Ki: 0.8 mM 14 4.1.1.112 Zn2+ 0.5 mM inhibitor in presence of 1 mM Mn2+, complete inhibition 14